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Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses

Published online by Cambridge University Press:  22 August 2022

P.H. Gobira Open the ORCID record for P.H. Gobira [Opens in a new window] ,
S.R. Joca  and
F.A. Moreira
P.H. Gobira*
Affiliation:
Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
S.R. Joca
Affiliation:
Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil Department of Biomedicine, Aarhus University, Aarhus, Denmark
F.A. Moreira
Affiliation:
Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
*
Author for correspondence: P.H. Gobira, Email: gobiraph@gmail.com
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Abstract

Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and methamphetamine, is a public health issue that substantially contributes to the global burden of disease. Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB1R and CB2R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB1R and CB2R and their interaction in the modulation of psychostimulant responses.

Keywords

psychostimulantsaddictionCB1 receptorsCB2 receptorsendocannabinoids
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 36 , Issue 2 , April 2024 , pp. 67 - 77
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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