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Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial

Published online by Cambridge University Press:  24 April 2024

Caitlin Victoria Hall Open the ORCID record for Caitlin Victoria Hall [Opens in a new window] ,
John Luke Twelves ,
Manish Saxena ,
Leonardo Scapozza  and
Thomas Gurry
Caitlin Victoria Hall
Affiliation:
Myota GmbH, Berlin, Germany
John Luke Twelves
Affiliation:
Lindus Health Limited, London, UK
Manish Saxena
Affiliation:
William Harvey Research Institute, Barts NIHR Biomedical Research Centre, Queen Mary University of London, London, UK
Leonardo Scapozza
Affiliation:
Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
Thomas Gurry*
Affiliation:
Myota GmbH, Berlin, Germany Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
*
*Corresponding author: Thomas Gurry, email thomas.gurry@unige.ch
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Abstract

Prebiotic fibre represents a promising and efficacious treatment to manage pre-diabetes, acting via complementary pathways involving the gut microbiome and viscosity-related properties. In this study, we evaluated the effect of using a diverse prebiotic fibre supplement on glycaemic, lipid and inflammatory biomarkers in patients with pre-diabetes. Sixty-six patients diagnosed with pre-diabetes (yet not receiving glucose-lowering medications) were randomised into treatment (thirty-three) and placebo (thirty-three) interventions. Participants in the treatment arm consumed 20 g/d of a diverse prebiotic fibre supplement, and participants in the placebo arm consumed 2 g/d of cellulose for 24 weeks. A total of fifty-one and forty-eight participants completed the week 16 and week 24 visits, respectively. The intervention was well tolerated, with a high average adherence rate across groups. Our results extend upon previous work, showing a significant change in glycated haemoglobin (HbA1c) in the treatment group but only in participants with lower baseline HbA1c levels (< 6 % HbA1c) (P = 0·05; treatment –0·17 ± 0·27 v. placebo 0·07 ± 0·29, mean ± sd). Within the whole cohort, we showed significant improvements in insulin sensitivity (P = 0·03; treatment 1·62 ± 5·79 v. placebo –0·77 ± 2·11) and C-reactive protein (PFWE = 0·03; treatment –2·02 ± 6·42 v. placebo 0·94 ± 2·28) in the treatment group compared with the placebo. Together, our results support the use of a diverse prebiotic fibre supplement for physiologically relevant biomarkers in pre-diabetes.

Keywords

Pre-diabetesGut microbiomePrebiotic fibre supplementRandomised controlled trialPlacebo-controlled
Type
Research Article
Information
British Journal of Nutrition , First View , pp. 1 - 9
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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