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Can whole-blood parameters be used in follow-up of children with rheumatic valvular heart disease?

Published online by Cambridge University Press:  30 August 2016

Derya Karpuz ,
Dilek Giray ,
Abdullah Ozyurt ,
Gulcin Bozlu ,
Selma Unal  and
Olgu Hallioglu
Derya Karpuz*
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Cardiology, University of Mersin Faculty of Medicine, Mersin, Turkey
Dilek Giray
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Cardiology, University of Mersin Faculty of Medicine, Mersin, Turkey
Abdullah Ozyurt
Affiliation:
Division of Pediatric Cardiology, Mersin Maternity and Children’s Hospital, Mersin, Turkey
Gulcin Bozlu
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey
Selma Unal
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Hematology, University of Mersin Faculty of Medicine, Mersin, Turkey
Olgu Hallioglu
Affiliation:
Department of Pediatrics, University of Mersin Faculty of Medicine, Mersin, Turkey Division of Pediatric Cardiology, University of Mersin Faculty of Medicine, Mersin, Turkey
*
Correspondence to: D. Karpuz, MD, Department of Pediatrics, Divison of Pediatric Cardiology, University of Mersin Faculty of Medicine, 34. Cadde, Ciftlikkoy Kampusu 33343 Mersin, Turkey. Tel: +90 324 241 0000; Fax: +90 324 241 0000; E-mail: drderyakarpuz@gmail.com
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Abstract

Objectives

The aim of the present study was to investigate the relationships between red blood cell distribution width, platelet distribution width, and mean platelet volume and the presence and severity of valvular involvement in patients with rheumatic heart disease.

Methods

Between April, 2012 and December, 2015, 151 patients who were admitted to the Pediatric Cardiology Unit with diagnosis of rheumatic heart disease and 148 healthy children were included to our study. Transthoracic echocardiography for all children was performed, and the values of red blood cell distribution width, platelet distribution width, and mean platelet volume, besides other blood count parameters, erythrocyte sedimentation rate, and C-reactive protein levels were recorded.

Results

Red blood cell distribution width, platelet distribution width, mean platelet volume, and C-reactive protein levels were significantly higher in patients with rheumatic heart disease when compared with healthy controls (p<0.01). Red blood cell distribution width was positively correlated with both C-reactive protein (r=0.271, p=0.035) and erythrocyte sedimentation rate (r=0.308, p=0.006). When single valve involvement was compared with both aortic valve and mitral valve involvement in the study group, red blood cell distribution width and platelet distribution width were higher in patients with double valve involvement; however, this was not statistically significant (p>0.05).

Conclusion

This is the first study in children with rheumatic heart disease that demonstrated significantly increased red blood cell distribution width, platelet distribution width, and mean platelet volume levels, as well as evaluated all three parameters together. Furthermore, red blood cell distribution width values in the chronical period of acute rheumatic fever, due to the positive correlation with the other chronic inflammatory markers, may help make the diagnosis in children.

Keywords

Red blood cell distribution widthmean platelet volumeplatelet distribution widthrheumatic heart disease
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 4 , May 2017 , pp. 764 - 769
Copyright
© Cambridge University Press 2016 

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References

1. Demirbağ, R, Sade, LE, Aydın, M, Bozkurt, A, Acartürk, E. The Turkish registry of heart valve disease. Turk Kardiyol Dern Ars 2013; 41: 1–10.Google ScholarPubMed
2. Carapetis, JR, Steer, AC, Mulholland, EK, Weber, M. The global burden of group a streptococcal diseases. Lancet Infect Dis 2005; 5: 685–694.CrossRefGoogle Scholar
3. Guilherme, L, Cyry, P, Demarchi, LM. Rheumatic heart disease: proinflamatory cytokines play a role in the progression and maintenance of valvular lesions. Am J Pathol 2004; 165: 1583–1591.Google Scholar
4. Settin, A, Abdel-Hady, H, El-baz, R, Saber, I. Gene polymorphisms of TNF-alpha(-308), IL-10(-1082), and IL-1Ra(VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol 2007; 28: 363–371.Google Scholar
5. Förhécz, Z, Gombos, T, Borgulya, G, Pozsonyi, Z, Prohászka, Z, Jánoskuti, L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009; 158: 659–666.Google Scholar
6. Güngör, B, Ozcan, KS, Ozpamuk Karadeniz, F, et al. Red cell distribution width is increased in patients with ascending aortic dilatation. Turk Kardiyol Dern Ars 2014; 42: 227–235.Google Scholar
7. Emans, ME, Gaillard, CA, Pfister, R, et al. Red cell distribution width is associated with physical inactivity and heart failure, independent of established risk factors, inflammation or iron metabolism; the EPIC-Norfolk study. Int J Cardiol 2013; 168: 3550–3555.Google Scholar
8. Isik, T, Uyarel, H, Tanboga, IH, et al. Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease. Coron Artery Dis 2012; 23: 51–56.CrossRefGoogle ScholarPubMed
9. Tonelli, M, Sacks, F, Arnold, M, Moye, L, Davis, B, Pfeffer, M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117: 163–168.Google Scholar
10. Bath, PM, Butterworth, RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157–161.CrossRefGoogle ScholarPubMed
11. Herve, P, Humbert, M, Sitbon, O, et al. Pathobiology of pulmonary hypertension: the role of platelets and thrombosis. Clin Chest Med 2001; 22: 451–458.Google Scholar
12. Pitchford, SC, Page, CP. Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 2006; 36: 399–401.Google Scholar
13. Bisno, A, Butchart, EG, Ganguly, NK, et al. Rheumatic fever and rheumatic heart disease: report of a WHO expert consultation. WHO expert consultation on rheumatic fever and rheumatic heart disease, 2001 October 29–November 1, Geneva, Switzerland. WHO Technical Report Series. World Health Organ Tech Rep Ser 2004; 923: 1–122.Google Scholar
14. Stollerman, GH. Rheumatogenic streptococci and autoimmunity. Clin Immunol Immunopathol 1991; 61: 131–142.Google Scholar
15. Endler, G, Klimesch, A, Sunder-Plassmann, H, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002; 117: 399–404.CrossRefGoogle Scholar
16. Arıca, S, Ozer, C, Arıca, V, Karakus, A, Celik, T, Gunesacar, R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatol Int 2012; 32: 3559–3563.CrossRefGoogle ScholarPubMed
17. Ozdemir, R, Karadeniz, C, Doksoz, OB, et al. Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis? Pediatr Cardiol 2014; 35: 53–56.CrossRefGoogle ScholarPubMed
18. Sert, A, Aypar, E, Odabas, D. Mean platelet volume in acute rheumatic fever. Platelets 2013; 24: 378–382.Google Scholar
19. Patel, KV, Semba, RD, Ferrucci, L, et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci 2010; 65: 258–265.CrossRefGoogle ScholarPubMed
20. Felker, GM, Allen, LA, Pocock, SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007; 50: 40–47.Google Scholar
21. Gölbasi, Z, Uçar, O, Keles, T, et al. Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease: evidence of ongoing inflammation. Eur J Heart Fail 2002; 4: 593–595.Google Scholar
22. Chiu-Braga, YY, Hayashi, SY, Schafranski, M, Messias-Reason, IJ. Further evidence of inflammation in chronic rheumatic valve disease (CRVD): high levels of advanced oxidation protein products (AOPP) and high sensitive C-reactive protein (hs-CRP). Int J Cardiol 2006; 109: 275–276.Google Scholar
23. Perlstein, TS, Weuve, J, Pfeffer, MA, Beckman, JA. Red blood cell distribution width and mortality risk in a communitybased prospective cohort. Arch Intern Med 2009; 169: 588–594.Google Scholar
24. Lappé, JM, Horne, BD, Shah, SH, et al. Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population. Clin Chim Acta 2011; 412: 2094–2099.Google Scholar
25. Ma, FL, Li, S, Li, XL, et al. Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center. Chin Med J (Engl) 2013; 126: 1053–1057.CrossRefGoogle ScholarPubMed
26. Akboğa, MK, Abacı, A, Canpolat, U, et al. Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis. Arch Turk Soc Cardiol 2015; 43: 227–233.CrossRefGoogle ScholarPubMed