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Diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension associated with CHD

Published online by Cambridge University Press:  31 March 2020

Eslam Hella ,
Doaa El Amrousy Open the ORCID record for Doaa El Amrousy [Opens in a new window] ,
Hesham El-Serogy  and
Amr Zoair
Eslam Hella
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University Hospital, Egypt
Doaa El Amrousy*
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University Hospital, Egypt
Hesham El-Serogy
Affiliation:
Clinical Pathology Department, Faculty of Medicine, Tanta University Hospital, Egypt
Amr Zoair
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University Hospital, Egypt
*
Author for correspondence: Prof. Doaa El Amrousy, Pediatric Department, Tanta University Hospital, Tanta, El Motasem Street No 6, Egypt. Tel: +20 1278155283; Fax: +20 403280477. E-mail: doaamoha@yahoo.com
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Abstract

Objective:

To evaluate the diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension (PH)-related CHD.

Patients and methods:

Forty patients with PH-related CHD were enrolled as group I, and 40 patients with CHD and no PH served as group II. Forty healthy children of matched age and sex served as a control group. Echocardiographic examinations and plasma connective tissue growth factor levels were performed for all included children. Cardiac catheterisation was performed for children with CHD only.

Results:

Plasma connective tissue growth factor levels were significantly higher in children with PH-related CHD compared to CHD-only patients and to control group and this elevation went with the severity of PH. There was a significant positive correlation between connective tissue growth factor levels and mean pulmonary pressure, pulmonary vascular resistance, and right ventricular diameter. A significant negative correlation was noticed between connective tissue growth factor levels, oxygen saturation, and right ventricular diastolic function. The sensitivity of plasma connective tissue growth factor as a diagnostic biomarker for PH was 95%, and the specificity was 90% at a cut-off value ≥650 pg/mL. The predictive value of plasma connective tissue growth factor for adverse outcome had a sensitivity of 88% and a specificity of 83% at a cut-off value ≥1900 pg/mL.

Conclusion:

Connective tissue growth factor is a promising biomarker with good diagnostic and predictive values in children with PH-related CHD.

Keywords

CTGFchildrenpulmonary hypertensionCHDdiagnosticpredictive
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 4 , April 2020 , pp. 533 - 538
Copyright
© The Author(s) 2020. Published by Cambridge University Press

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