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Evaluation of left ventricular systolic functions in two-dimensional speckle-tracking echocardiography in children with chronic renal failure

Published online by Cambridge University Press:  14 December 2020

Ozgur Kizilca Open the ORCID record for Ozgur Kizilca [Opens in a new window] ,
Derya Ozmen ,
Tulay Demircan Open the ORCID record for Tulay Demircan [Opens in a new window] ,
Nuh Yilmaz ,
Mustafa Kir ,
Alper Soylu ,
Nurettin Unal  and
Salih Kavukcu
Ozgur Kizilca*
Affiliation:
Department of Pediatric Cardiology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Derya Ozmen
Affiliation:
Department of Pediatric Nephrology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Tulay Demircan
Affiliation:
Department of Pediatric Cardiology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Nuh Yilmaz
Affiliation:
Department of Pediatric Cardiology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Mustafa Kir
Affiliation:
Department of Pediatric Cardiology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Alper Soylu
Affiliation:
Department of Pediatric Nephrology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Nurettin Unal
Affiliation:
Department of Pediatric Cardiology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
Salih Kavukcu
Affiliation:
Department of Pediatric Nephrology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey
*
Author for corresponence: Dr O. Kizilca, Department of Pediatric Cardiology, Dokuz Eylul University, Faculty of Medicine, Izmir 35340, Turkey. Tel: +90 232 4126175; Fax: +90 232 2599723. E-mail: drozca@yahoo.com
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Abstract

Background and aim:

Chronic kidney disease may lead to left ventricular dysfunction. Early detection of cardiovascular disease in children with chronic kidney disease is essential to prevent cardiovascular morbidity and mortality in early adulthood. This study aimed to document the dysfunction using methods such as two-dimensional speckle-tracking echocardiography in the early stage.

Methods:

A total of 34 patients diagnosed with chronic kidney disease (mean age ± standard deviation, 10.5 ± 4.1 years) and 37 sex- and age-matched (mean age 9.8 ± 4.2 years) healthy controls were studied. The results of the two groups were compared along with those of the published studies.

Results:

The echocardiography measurements had no significant difference in the end-diastolic and end-systolic diameter values of left ventricular, ejection fraction, shortening fraction, mitral E value, mitral A value, and E/A ratio between the groups. Pulmonary artery systolic and diastolic pressure and left ventricular mass index were significantly higher in the patient group (p < 0.01). The longitudinal global strain values in the apical four-chamber, three-chamber, and two-chamber views and the total global strain values were significantly lower in the patients (p < 0.01). The circumferential global strain values in the apical, mid, basal, and total global strain were lower in the patient group, but this difference was statistically significant in the apical global and total global strain values (p < 0.05).

Conclusions:

Speckle-tracking echocardiography might help identify subclinical left ventricular dysfunction in patients with chronic kidney disease with unremarkable conventional echocardiography.

Keywords

Chronic kidney diseasespeckle-tracking echocardiographyventricular dysfunction
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 3 , March 2021 , pp. 421 - 428
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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