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Experimental studies of hypothermic circulatory arrest and low flow bypass

Published online by Cambridge University Press:  19 August 2008

Richard A. Jonas
Richard A. Jonas*
Affiliation:
From the Department of Cardiac Surgery, Children's Hospital, Boston
*
Dr. Richard A. Jonas, Department of Cardiac Surgery, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
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Extract

Although the brain is the organ most sensitive to total bodily ischemia, and probably also most sensitive to the deleterious effects of cardiopulmonary bypass, it is also the most difficult organ in which to quantitate function accurately. Clinical studies allow sensitive neuropsychometric testing, as discussed elsewhere in this issue (see Wernovsky et al, p. 308). This is not possible in studies using animals. Even testing of gross neurological integrity in animals is complicated by the associated dysfunction of other organs which accompanies the insult of cardiopulmonary bypass with or without circulatory arrest on the whole body. For example, how should one evaluate an animal undergoing neurological testing which is unable to walk or eat, perhaps because of severe cardiorespiratory or gastrointestinal dysfunction following cardiopulmonary bypass and circulatory arrest. What is the contribution of neurological dysfunction to this state? Most importantly, how is the animal scored which does not survive, even though this may be a result of multiorgan dysfunction?

Keywords

Deep hypothermic circulatory arrestlow flow bypassmagnetic resonance spectroscopycerebral metabolismcerebral blood flow
Type
World Forum for Pediatric Cardiology Symposium on Cardiopulmonary Bypass (Part 1)
Information
Cardiology in the Young , Volume 3 , Issue 3 , July 1993 , pp. 299 - 307
Copyright
Copyright © Cambridge University Press 1993

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