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Liver T1/T2 values with cardiac MRI during respiration

Published online by Cambridge University Press:  25 October 2022

Hideharu Oka Open the ORCID record for Hideharu Oka [Opens in a new window] ,
Kouichi Nakau ,
Sadahiro Nakagawa ,
Rina Imanishi ,
Sorachi Shimada ,
Yuki Mikami ,
Kazunori Fukao ,
Kunihiro Iwata  and
Satoru Takahashi
Hideharu Oka*
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Kouichi Nakau
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Sadahiro Nakagawa
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Rina Imanishi
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Sorachi Shimada
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Yuki Mikami
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Kazunori Fukao
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Kunihiro Iwata
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Satoru Takahashi
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
*
Author for correspondence: Hideharu Oka, Department of Pediatrics, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. E-mail: oka5p@asahikawa-med.ac.jp
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Abstract

Background:

Assessing the hepatic status of children with CHD is very important in the post-operative period. This study aimed to assess the usefulness of paediatric liver T1/T2 values and to evaluate the impact of respiration on liver T1/T2 values.

Methods:

Liver T1/T2 values were evaluated in 69 individuals who underwent cardiac MRI. The mean age of the participants was 16.2 ± 9.8 years. Two types of imaging with different breathing methods were possible in 34 participants for liver T1 values and 10 participants for liver T2 values.

Results:

The normal range was set at 620–830 msec for liver T1 and 25–40 ms for liver T2 based on the data obtained from 17 healthy individuals. The liver T1/T2 values were not significantly different between breath-hold and free-breath imaging (T1: 769.4 ± 102.8 ms versus 763.2 ± 93.9 ms; p = 0.148, T2: 34.9 ± 4.0 ms versus 33.6 ± 2.4 ms; p = 0.169). Higher liver T1 values were observed in patients who had undergone Fontan operation, tetralogy of Fallot operation, or those with chronic viral hepatitis. There was a trend toward correlation between liver T1 values and liver stiffness (R = 0.65, p = 0.0004); and the liver T1 values showed a positive correlation with the shear wave velocity (R = 0.62, p = 0.0006).

Conclusions:

Liver T1/T2 values were not affected by breathing patterns. Because liver T1 values tend to increase with right heart overload, evaluation of liver T1 values during routine cardiac MRI may enable early detection of future complications.

Keywords

CHDcardiac MRIbreathing patternsliver elastographyhepatic congestion
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 10 , October 2023 , pp. 1859 - 1865
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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