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Potential role of salivary cortisol levels to reflect stress response in children undergoing congenital heart surgery

Published online by Cambridge University Press:  01 April 2022

Serçin Taşar ,
Nur Dikmen ,
İsmail Bulut ,
Yunus Emre Haskılıç ,
Rukiye Ünsal Saç ,
Mehmet Şenes ,
Medine Ayşin Taşar  and
Mehmet Taşar Open the ORCID record for Mehmet Taşar [Opens in a new window]
Serçin Taşar
Affiliation:
Department of Pediatrics, Ankara Education and Research Hospital, Ankara, Turkey
Nur Dikmen
Affiliation:
Department of Pediatric Cardiovascular Surgery, Dr.Sami Ulus Maternity, Child Health and Disease Education and Research Hospital, Ankara, Turkey
İsmail Bulut
Affiliation:
Department of Pediatrics, Ankara Education and Research Hospital, Ankara, Turkey
Yunus Emre Haskılıç
Affiliation:
Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey
Rukiye Ünsal Saç
Affiliation:
Department of Pediatrics, Ankara Education and Research Hospital, Ankara, Turkey
Mehmet Şenes
Affiliation:
Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey
Medine Ayşin Taşar
Affiliation:
Department of Pediatric Emergency, Ankara Education and Research Hospital, Ankara, Turkey
Mehmet Taşar*
Affiliation:
Department of Pediatric Cardiovascular Surgery, Dr.Sami Ulus Maternity, Child Health and Disease Education and Research Hospital, Ankara, Turkey
*
Author for correspondence: Mehmet Taşar, MD, Dr. Sami Ulus Maternity, Child Health and Disease Education and Research Hospital, Pediatric Cardiovascular Surgery, Ankara, Turkey. E-mail: mehmet.tasar@hotmail.com
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Abstract

Aim:

This study aimed to provide baseline information on the potential role of salivary cortisol in reflecting the stress response in children undergoing congenital heart surgery.

Patients and methods:

Children underwent congenital cardiac surgery, aged between one and seventeen years were included. Saliva samples were collected pre- and postoperatively by the health caregiver immediately after the children woke up (07:00–09:00 am) and at 06:00 pm in the evening. Salivary cortisol levels were compared with the reference index values from a large database.

Results:

Median baseline preoperative morning salivary cortisol levels were significantly lower than the reference values in both < 5-year-old females (p = 0.01) and males (p = 0.04) and in males between 11 and 20 years of age (p = 0.01). Median baseline preoperative evening salivary cortisol levels were significantly higher than the reference value in < 5-year-old females (p = 0.01) and between 5 and 10 years of age (p = 0.04) and in between 11- and20-year-old males (p = 0.01). Median postoperative morning salivary cortisol levels were significantly lower than the reference value in both < 5-year-old females (p = 0.01) and males (p = 0.04) and females between 5 and 10 year of age (p = 0.04). Median postoperative evening salivary cortisol levels were significantly higher than the reference value in < 5-year-old females (p = 0.01) and between 5- and 10-year-old females (p = 0.04).

Conclusion:

Diurnal variability of salivary cortisol levels in children undergoing congenital heart surgery may be different from normal reference values both in preoperative and postoperative periods that can be a predictive indicator of anxiety on pre- and postoperative period for children that undergoing cardiac surgery.

Keywords

CHDstress responsesalivary cortisolpaediatric population
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 1 , January 2023 , pp. 106 - 112
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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