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Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience

Published online by Cambridge University Press:  03 December 2018

Fernando M. Berganza ,
Cesar Gonzalez de Alba ,
Alexander C. Egbe ,
Sergio Bartakian  and
John Brownlee
Fernando M. Berganza
Affiliation:
Department of General Pediatrics, Driscoll Children’s Hospital, Corpus Christi, TX, USA
Cesar Gonzalez de Alba
Affiliation:
Department of General Pediatrics, Driscoll Children’s Hospital, Corpus Christi, TX, USA
Alexander C. Egbe
Affiliation:
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA
Sergio Bartakian
Affiliation:
Health Science Center, University of Texas, San Antonio, TX, USA
John Brownlee*
Affiliation:
Department of Pediatric Cardiology, Driscoll Children’s Hospital, Corpus Christi, TX, USA
*
Author for correspondence: J. Brownlee, MD, FAAP, FACC, Heart Center, Driscoll Children’s Hospital, 3533 S Alameda St, Corpus Christi, TX 78411, USA. Tel: 361 694 5086; Fax: 361 855 9518; E-mail: John.Brownlee@dchstx.org
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Abstract

Rationale

Aspirin resistance has been reported in up to 80% of children with cardiovascular defects undergoing surgery. Because of a patient who had embolic stroke while on therapeutic aspirin dose but in whom aspirin resistance was present on his thromboelastography platelet mapping, we chose to obtain thromboelastography platelet mapping on cardiac patients on aspirin to assess their risk.

Objectives

This study evaluates aspirin resistance noted in these patients and their characteristics.

Methods and results

This is a retrospective study of 25 patients taking aspirin for a month at therapeutic dose. In total, 11 female patients were enrolled. Ages in all subjects were 5 months to 27 years. A total of 19 patients had a Fontan surgery. Three had a cavopulomanary anastomosis, one had a hybrid procedure, and two had coronary anomalies. Compliance was assessed at the time of the clinic visit. Aspirin resistance was defined as platelet inhibition below 50%. Variables evaluated were level of platelet inhibition, age, body mass index, and gender.

Keywords

Aspirin resistancethromboelastographyplatelet mappingCHDgeneral cardiology
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 1 , January 2019 , pp. 24 - 29
Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Berganza FM, Gonzalez de Alba C, Egbe AC, Bartakian S, Brownlee J. (2018) Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience. Cardiology in the Young29: 24–29. doi: 10.1017/S1047951118000021

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