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The importance of optimal body condition to maximise reproductive health and perinatal outcomes in pigs

Published online by Cambridge University Press:  24 June 2022

Bruno BD Muro
Affiliation:
Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo (USP), Campus Pirassununga, SP, Brazil
Rafaella F Carnevale
Affiliation:
Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo (USP), Campus Pirassununga, SP, Brazil
Diego F Leal
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Sciences, University of São Paulo (USP), Campus Pirassununga, Pirassununga, SP, Brazil
Glen W Almond
Affiliation:
Department of Population Health & Pathobiology, College of Veterinary Medicine, North Carolina State University (NCSU), Raleigh, North Carolina, USA
Matheus S Monteiro
Affiliation:
Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Sciences, University of São Paulo (USP), Campus São Paulo, São Paulo, SP, Brazil
André P Poor
Affiliation:
Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Sciences, University of São Paulo (USP), Campus São Paulo, São Paulo, SP, Brazil
Allan P Schinckel
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, Indiana, USA
Cesar AP Garbossa*
Affiliation:
Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo (USP), Campus Pirassununga, SP, Brazil
*
*Corresponding author: Cesar AP Garbossa, email cgarbossa@usp.br

Abstract

Overnutrition or undernutrition during all or part of the reproductive cycle predisposes sows to metabolic consequences and poor reproductive health which contributes to a decrease in sow longevity and an increase in perinatal mortality. This represents not only an economic problem for the pig industry but also results in poor animal welfare. To maximise profitability and increase sustainability in pig production, it is pivotal to provide researchers and practitioners with synthesised information about the repercussions of maternal obesity or malnutrition on reproductive health and perinatal outcomes, and to pinpoint currently available nutritional managements to keep sows’ body condition in an optimal range. Thus, the present review summarises recent work on the consequences of maternal malnutrition and highlights new findings.

Type
Review Article
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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References

Zhou, Y, Xu, T, Wu, Y, et al. (2019) Oxidative stress and inflammation in sows with excess Backfat: up-regulated cytokine expression and elevated oxidative stress biomarkers in placenta Animals 10, 796.CrossRefGoogle Scholar
Barb, CR, Kraeling, RR, Rampacek, GB, et al. (2006) The role of neuropeptide Y and interaction with leptin in regulating feed intake and luteinizing hormone and growth hormone secretion in the pig. Reproduction 131, 11271135.CrossRefGoogle ScholarPubMed
Heerwagen, MJR, Miller, MR, Barbour, LA, et al. (2010) Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Integr Comp Physiol 299, R711R722.CrossRefGoogle ScholarPubMed
NRC (2012) Nutrient Requirements of Swine, 11th revised edition. Washington, DC: National Academies Press.Google Scholar
Feyera, T & Theil, PK (2017) Energy and lysine requirements and balances of sows during transition and lactation: a factorial approach. Livest Sci 201, 5057.CrossRefGoogle Scholar
Vázquez-Gómez, M, García-Contreras, C, Torres-Rovira, L, et al. (2018) Maternal undernutrition and offspring sex determine birth-weight, postnatal development and meat characteristics in traditional swine breeds. J Anim Sci Biotechnol 9, 115.CrossRefGoogle ScholarPubMed
Tian, L, Wen, AY, Dong, SS, et al. (2019) Excessive backfat of sows at mating promotes oxidative stress and up-regulates mitochondrial-mediated apoptotic pathway in the full-term placenta. Livest Sci 222, 7182.CrossRefGoogle Scholar
Oliviero, C, Heinonen, M, Valros, A, et al. (2010) Environmental and sow-related factors affecting the duration of farrowing. Anim Reprod Sci 119, 8591.CrossRefGoogle ScholarPubMed
Gonçalves, MAD, Gourley, KM, Dritz, SS, et al. (2016) Effects of amino acids and energy intake during late gestation of high-performing gilts and sows on litter and reproductive performance under commercial conditions1,2. J Anim Sci 94, 19932003.CrossRefGoogle Scholar
Gourley, KM, Calderon, HI, Woodworth, JC, et al. (2020) Sow and piglet traits associated with piglet survival at birth and to weaning. J Anim Sci 98, skaa187.CrossRefGoogle Scholar
Decaluwé, R, Maes, D, Declerck, I, et al. (2013) Changes in back fat thickness during late gestation predict colostrum yield in sows. Animal 7, 19992007.CrossRefGoogle Scholar
Cheng, C, Wu, X, Zhang, X, et al. (2020) Obesity of sows at late pregnancy aggravates metabolic disorder of perinatal sows and affects performance and intestinal health of piglets. Animals 10, 111.Google Scholar
Engblom, L, Calderón Díaz, JA, Nikkilä, M, et al. (2016) Genetic analysis of sow longevity and sow lifetime reproductive traits using censored data. J Anim Breed Genet 133, 138144.CrossRefGoogle ScholarPubMed
Maes, DGD, Janssens, GPJ, Delputte, P, et al. (2004) Back fat measurements in sows from three commercial pig herds: relationship with reproductive efficiency and correlation with visual body condition scores. Livest Prod Sci 91, 5767.CrossRefGoogle Scholar
Knauer, MT & Baitinger, DJ (2015) The sow body condition caliper. Appl Eng Agric 31, 175178.Google Scholar
Schenkel, AC, Bernardi, ML, Bortolozzo, FP, et al. (2010) Body reserve mobilization during lactation in first parity sows and its effect on second litter size. Livest Sci 132, 165172.CrossRefGoogle Scholar
Knauer, MT, Stalder, KJ, Karriker, L, et al. (2007) A descriptive survey of lesion from cull sows harvested at two Midwestern U.S. facilities. Prev Vet Med 82, 198212.CrossRefGoogle ScholarPubMed
Charrette, R, Bigras-Poulin, M & Martineau, GP (1996) Body condition evaluation in sows. Livest Prod Sci 46, 107115.CrossRefGoogle Scholar
Ferrell, CL & Cornelius, SG (1984) Estimation of body composition of pigs. J Anim Sci 58, 903912.CrossRefGoogle ScholarPubMed
Swantek, PM, Crenshaw, JD, Marchello, MJ, et al. (1992) Bioelectrical impedance: a nondestructive method to determine fat-free mass of live market swine and pork carcasses, J Anim Sci 70, 169177.CrossRefGoogle ScholarPubMed
Mullan, BP & Williams, IH (1990). The chemical composition of sows during their first lactation. Anim Sci 51, 375387.CrossRefGoogle Scholar
Thongkhuy, S, Chuaychu, SB, Burarnrak, P, et al. (2020) Effect of backfat thickness during late gestation on farrowing duration, piglet birth weight, colostrum yield, milk yield and reproductive performance of sows. Livest Sci 234, 103983.CrossRefGoogle Scholar
Roongsitthichai and Tummaruk, (2014) Importance of backfat thickness to reproductive performance in female pigs. Thai J Vet Med 44, 171178.CrossRefGoogle Scholar
Farmer, C, Martineau, JP, Méthot, S, et al. (2017) Comparative study on the relations between backfat thickness in late-pregnant gilts, mammary development and piglet growth. Transl Anim Sci 1, 154159.CrossRefGoogle ScholarPubMed
De Rensis, F, Gherpelli, M, Superchi, P, et al. (2005) Relationships between backfat depth and plasma leptin during lactation and sow reproductive performance after weaning. Anim Reprod Sci 90, 95100.CrossRefGoogle ScholarPubMed
Rozeboom, DW, Pettigrew, JE, Moser, RL, et al. (1996) Influence of gilt age and body composition at first breeding on sow reproductive performance and longevity. J Anim Sci 74, 138150.CrossRefGoogle ScholarPubMed
Tian, L, Dong, SS, Hu, J, et al. (2018) The effect of maternal obesity on fatty acid transporter expression and lipid metabolism in the full-term placenta of lean breed swine. J Anim Physiol Anim Nutr (Berl) 104, 170180.Google Scholar
Kim, JS, Yang, X, Pangeni, D, et al. (2015) Relationship between backfat thickness of sows during late gestation and reproductive efficiency at different parities. Acta Agric Scand A Anim Sci 65, 18.Google Scholar
Kummer, R, Bernardi, M, Schenkel, A, et al. (2009) Reproductive performance of gilts with similar age but with different growth rate at the onset of puberty stimulation. Reprod Domest Anim 44, 255259.CrossRefGoogle ScholarPubMed
Amdi, C, Giblin, L, Ryan, T, et al. (2014) Maternal backfat depth in gestating sows has a greater influence on offspring growth and carcass lean yield than maternal feed allocation during gestation. Animal 8, 236244.CrossRefGoogle Scholar
Li, JW, Hu, J, Wei, M, et al. (2019) The effects of maternal obesity on porcine placental efficiency and proteome. Animals 9, 546.CrossRefGoogle ScholarPubMed
Zhou, Y, Xu, T, Cai, A, et al. (2018) Excessive backfat of sows at 109 d of gestation induces lipotoxic placental environment and is associated with declining reproductive performance. J Anim Sci 96: 250257.CrossRefGoogle ScholarPubMed
Superchi, P, Saleri, R, Menčik, S, et al. (2019) Relationships among maternal backfat depth, plasma adipokines and the birthweight of piglets. Livest Sci 223, 138143.CrossRefGoogle Scholar
Tummaruk, P (2013) Post-parturient disorders and backfat loss in tropical sows in relation to backfat thickness before farrowing and postpartum intravenous supportive treatment. Asian-Aust J Anim Sci 26, 171177.CrossRefGoogle ScholarPubMed
Filha, WSA, Bernardi, ML, Wentz, I, et al. (2009) Growth rate and age at boar exposure as factors influencing gilt puberty. Livest Sci 120, 5157.CrossRefGoogle Scholar
Song, T, Lu, J, Deng, Z, et al. (2018) Maternal obesity aggravates the abnormality of porcine placenta by increasing N6-methyladenosine. Int J Obes 42, 18121820.CrossRefGoogle Scholar
Cools, A, Maes, D, Decaluwé, R, et al. (2014) Ad libitum feeding during the peripartal period affects body condition, reproduction results and metabolism of sows. Anim Reprod Sci 145, 130140.CrossRefGoogle ScholarPubMed
Whittemore, CT & Kyriazakis, I (2008). Whittemore’s Science and Practice of Pig Production, 3rd edition. Oxford, UK: Blackwell Publishing Ltd.Google Scholar
Surana, R, Sikka, S, Cai, W, et al. (2014) Secreted frizzled related proteins: implications in cancers. Biochim Biophys Acta – Rev Cancer 1845, 5365.CrossRefGoogle ScholarPubMed
Cools, A, Maes, D, Decaluwé, R, et al. (2013) Peripartum changes in orexigenic and anorexigenic hormones in relation to back fat thickness and feeding strategy of sows. Domest Anim Endocrinol 45, 2227.CrossRefGoogle ScholarPubMed
Coffey, MT, Diggs, BG, Handlin, DL, et al. (1994) Effects of dietary energy during gestation and lactation on reproductive performance of sows: a cooperative study. J Anim Sci 72, 49.CrossRefGoogle ScholarPubMed
Willis, HJ, Zak, LJ & Foxcroft, GR (2003) Duration of lactation, endocrine and metabolic state, and fertility of primiparous sows. J Anim Sci 81, 20882102.CrossRefGoogle ScholarPubMed
Clowes, EJ, Aherne, FX, Schaefer, AL, et al. (2003) Parturition body size and body protein loss during lactation influence performance during lactation and ovarian function at weaning in first-parity sows. Anim Sci 81, 15171528.CrossRefGoogle ScholarPubMed
Quesnel, H, Mejia-Guadarrama, CA, Dourmad, JY, et al. (2005) Dietary protein restriction during lactation in primiparous sows with different live weights at farrowing: I. Consequences on sow metabolic status and litter growth. Reprod Nutr Dev 45, 3956.CrossRefGoogle ScholarPubMed
Costermans, NGJ, Soede, NM, Middelkoop, A, et al. (2020) Influence of the metabolic state during lactation on milk production in modern sows. Animal 14, 25432553.CrossRefGoogle ScholarPubMed
Fitzgerald, RF, Stalder, KJ, Dixon, PM, et al. (2009) The accuracy and repeatability of sow body condition scoring. Prof Anim Sci 25, 415425.CrossRefGoogle Scholar
Brewer, CJ & Balen, AH (2010) The adverse effects of obesity on conception and implantation. Reproduction 140, 347364.CrossRefGoogle ScholarPubMed
Ahlsson, F, Diderholm, B, Ewald, U, et al. (2013) Adipokines and their relation to maternal energy substrate production, insulin resistance and fetal size. Eur J Obstet Gynecol Reprod Biol 168, 2629.CrossRefGoogle ScholarPubMed
Weber, TE & Spurlock, ME (2004) Leptin alters antibody isotype in the pig in vivo, but does not regulate cytokine expression or stimulate STAT3 signaling in peripheral blood monocytes in vitro. J Anim Sci 82, 16301640.CrossRefGoogle ScholarPubMed
Fowden, A, Apatu, R & Silver, M (1995) The glucogenic capacity of the fetal pig: developmental regulation by cortisol. Exp Physiol 80, 457467.CrossRefGoogle ScholarPubMed
Muhlhausler, BS, Gugusheff, JR, Ong, ZY, et al. (2013) Nutritional approaches to breaking the intergenerational cycle of obesity. Can J Physiol Pharmacol 91, 421428.CrossRefGoogle ScholarPubMed
Gonzalez-Bulnes, A, Pallares, P & Ovilo, C (2012) Ovulation, implantation and placentation in females with obesity and metabolic disorders: life in the balance. Endocrine, Metab Immune Disord – Drug Targets 11, 285301.CrossRefGoogle Scholar
Martin, SS, Qasim, A & Reilly, MP (2008) Leptin resistance. J Am Coll Cardiol 52, 12011210.CrossRefGoogle ScholarPubMed
Vieira-Potter, VJ, Lee, S, Bayless, DS, et al. (2015) Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs. Obesity 23, 24212429.CrossRefGoogle ScholarPubMed
Patterson, J & Foxcroft, G (2019) Gilt management for fertility and longevity. Animals 9, 434.CrossRefGoogle ScholarPubMed
Quinn, AJ (2014) Limb health in pigs: the prevalence and risk factors for lameness, limb lesions and claw lesions in pigs, and the influence of gilt nutrition on indicators of limb health. Ph.D. Thesis, University of Warwick, Coventry, UK.Google Scholar
Boyle, L & Björklund, L (2007) Effects of fattening boars in mixed or single sex groups and split marketing on pig welfare. Anim Welf 16, 259262.CrossRefGoogle Scholar
Quinn, AJ, Green, LE, Lawlor, PG, et al. (2015) The effect of feeding a diet formulated for developing gilts between 70kg and 140kg on lameness indicators and carcass traits. Livest Sci 174, 8795.CrossRefGoogle Scholar
Levis, DG, Vernon, DL & Rozeboom, DW (2005) Development of gilts and boars for efficient reproduction. In Pork Industry Handbook; Digital Commons, University of Nebraska: Lincoln, NE, USA, 5, 18.Google Scholar
Gill, BP & Taylor, L (1999) The nutritional management of gilts to enlance Lifetime productivity: second progress report on the Stotfold Gilt trial—body composition and first litter performance. Pig Soc Feed Technol: Coventry, UK 2, 14.Google Scholar
Knauer, MT, Cassady, JP, Newcom, DW, et al. (2012) Gilt development traits associated with genetic line, diet and fertility. Livest Sci 148, 159167.CrossRefGoogle Scholar
Tummaruk, P, Tantasuparuk, W, Techakumphu, M, et al. (2007) Age, body weight and backfat thickness at first observed oestrus in crossbred Landrace × Yorkshire gilts, seasonal variations and their influence on subsequence reproductive performance. Anim Reprod Sci 99, 167181.CrossRefGoogle ScholarPubMed
Flisar, T, Malovrh, Š, Urankar, J, et al. (2012) Effect of gilt growth rate and back fat thickness on reproductive performance. Acta Agric Slov 100, 199203.Google Scholar
Engblom, L, Lundeheim, N, Strandberg, E, et al. (2008): Factors affecting length of productive life in Swedish commercial sows. J Anim Sci 86, 432441.CrossRefGoogle ScholarPubMed
Koketsu, Y, Takahashi, H & Akachi, K (1999) Longevity, lifetime pig production and productivity, and age at first conception in a cohort of gilts observed over six years on commercial farms. J Vet Med Sci 61, 10011005.CrossRefGoogle Scholar
Lammers, PJ, Stender, DR & Honeyman, MS (2017) Niche Pork Production. Ames, IA: Iowa State University.Google Scholar
Filha, WSA, Bernardi, ML, Wentz, I, et al. (2010) Reproductive performance of gilts according to growth rate and backfat thickness at mating. Anim Reprod Sci 121, 139144.CrossRefGoogle Scholar
Faccin, JEG, Laskoski, F, Lesskiu, PE, et al. (2017) Reproductive performance, retention rate, and age at the third parity according to growth rate and age at first mating in the gilts with a modern genotype. Acta Sci Vet 45, 1452.Google Scholar
Young, MG, Tokach, MD, Aherne, FX, et al. (2008) Effect of space allowance during rearing and selection criteria on performance of gilts over three parities in a commercial swine production system. J Anim Sci 86, 31813193.CrossRefGoogle Scholar
Stern, S, Lundeheim, N, Johansson, K, et al. (1995) Osteochondrosis and leg weakness in pigs selected for lean tissue growth rate. Livest Prod Sci 44, 4552.CrossRefGoogle Scholar
Jørgensen, B & Sørensen, MT (1998) Different rearing intensities of gilts: II. Effects on subsequent leg weakness and longevity. Livest Prod Sci 54, 167171.CrossRefGoogle Scholar
Małopolska, MM, Tuz, R, Lambert, BD, et al. (2018) The replacement gilt: current strategies for improvement of the breeding herd. J Swine Health Prod 26, 208214.CrossRefGoogle Scholar
Tantasuparuk, W, Techakumphu, M & Dornin, S (2005) Relationships between ovulation rate and litter size in purebred Landrace and Yorkshire gilts. Theriogenology 63, 11421148.CrossRefGoogle ScholarPubMed
Kasprzyk, A & Łucki, M (2014) Analysis of the variation of reproductive traits of Danhybryd LY sows. Ann Univ Mariae Curie-Skłodowska 32, 715.Google Scholar
Geisert, RD & Yelich, J V (1997) Regulation of conceptus development and attachment in pigs. J Reprod Fertil Suppl 52, 133149.Google ScholarPubMed
Bazer, FW & Johnson, GA (2014) Pig blastocyst-uterine interactions. Differentiation 87, 5265.CrossRefGoogle ScholarPubMed
Pope, WF, Xie, S, Broermann, DM, et al. (1990) Causes and consequences of early embryonic diversity in pigs. J Reprod Fertil Suppl 40, 251260.Google ScholarPubMed
Gonzalez-Añover, P, Encinas, T, Torres-Rovira, L, et al. (2011) Ovulation rate, embryo mortality and intrauterine growth retardation in obese swine with gene polymorphisms for leptin and melanocortin receptors. Theriogenology 75, 3441.CrossRefGoogle ScholarPubMed
Alfer, J (2000) The endometrium as a novel target for leptin: differences in fertility and subfertility. Mol Hum Reprod 6, 595601.CrossRefGoogle ScholarPubMed
Robker, RL (2008) Evidence that obesity alters the quality of oocytes and embryos. Pathophysiology 15, 115121.CrossRefGoogle ScholarPubMed
Castellucci, M (2000) Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Mol Hum Reprod 6, 951958.CrossRefGoogle ScholarPubMed
Ashworth, CJ, Toma, LM & Hunter, MG (2009) Nutritional effects on oocyte and embryo development in mammals: implications for reproductive efficiency and environmental sustainability. Philos Trans R Soc B Biol Sci 364, 33513361.CrossRefGoogle ScholarPubMed
Nohr, EA, Vaeth, M, Bech, BH, et al. (2007) Maternal obesity and neonatal mortality according to subtypes of preterm birth. Obstet Gynecol 110, 10831090.CrossRefGoogle Scholar
Wu, G, Bazer, FW, Burghardt, RC, et al. (2010) Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production. J Anim Sci 88, 195204.CrossRefGoogle ScholarPubMed
De-Bem, THC, Tinning, H, Vasconcelos, EJR, et al. (2021) Endometrium on-a-chip reveals insulin- and glucose-induced alterations in the transcriptome and proteomic secretome. Endocrinology 162, bqab054.CrossRefGoogle Scholar
Torres-Rovira, L, Astiz, S, Gonzalez-Añover, P, et al. (2014) Intake of high saturated-fat diets disturbs steroidogenesis, lipid metabolism and development of obese-swine conceptuses from early-pregnancy stages. J Steroid Biochem Mol Biol 139, 130137.CrossRefGoogle ScholarPubMed
Muro, BBD, Carnevale, RF, Leal, DF, et al. (2020) Supplemental progesterone during early pregnancy exerts divergent responses on embryonic characteristics in sows and gilts. Animal 14, 12341240.CrossRefGoogle ScholarPubMed
Bazer, FW, Kim, J, Ka, H, et al. (2012) Select nutrients in the uterine lumen of sheep and pigs affect conceptus development. J Reprod Dev 58, 180188.CrossRefGoogle ScholarPubMed
Wang, H, Fu, J & Wang, A (2014) Expression of obesity gene and obesity gene long form receptor in endometrium of Yorkshire sows during embryo implantation. Mol Biol Rep 41, 15971606.CrossRefGoogle Scholar
Higgins, L, Greenwood, SL, Wareing, M, et al. (2011) Obesity and the placenta: a consideration of nutrient exchange mechanisms in relation to aberrant fetal growth. Placenta 32, 17.CrossRefGoogle ScholarPubMed
Nakatsukasa, H, Masuyama, H, Takamoto, N, et al. (2008) Circulating leptin and angiogenic factors in preeclampsia patients. Endocr J 5, 565573.CrossRefGoogle Scholar
Kawamura, K, Sato, N, Fukuda, J, et al. (2002) Leptin promotes the development of mouse preimplantation embryos in vitro. Endocrinology 143, 19221931.CrossRefGoogle ScholarPubMed
Sierra-Honigmann, MR (1998) Biological action of leptin as an angiogenic factor. Science 281, 16831686.CrossRefGoogle ScholarPubMed
Islami, D (2003) Modulation of placental vascular endothelial growth factor by leptin and hCG. Mol Hum Reprod 9, 395398.CrossRefGoogle ScholarPubMed
Morley, JE, Alshaher, MM, Farr, SA, et al. (1999) Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides 20, 595600.CrossRefGoogle Scholar
McPherson, RL, Ji, F, Wu, G, et al. (2004) Growth and compositional changes of fetal tissues in pigs1. J Anim Sci 82, 25342540.CrossRefGoogle Scholar
Goodband, RD, Tokach, MD, Goncalves, MAD, et al. (2013) Nutritional enhancement during pregnancy and its effects on reproduction in swine. Anim Front 3, 6875.CrossRefGoogle Scholar
Solà-Oriol, D & Gasa, J (2017) Feeding strategies in pig production: sows and their piglets. Anim Feed Sci Technol 233, 3452.CrossRefGoogle Scholar
Wang, J, Yang, M, Cao, M, et al. (2016) Moderately increased energy intake during gestation improves body condition of primiparous sows, piglet growth performance, and milk fat and protein output. Livest Sci 194, 2030.CrossRefGoogle Scholar
Wiecek, J, Rekiel, A & Bartosik, J (2018) Colostrum and milk quality of sows fed different diets during mid-pregnancy. J Anim Feed Sci 27, 248254.CrossRefGoogle Scholar
Cerisuelo, A, Sala, R, Gasa, J, et al. (2008) Effects of extra feeding during mid-pregnancy on gilts productive and reproductive performance. Spanish J Agric Res 6, 219229.CrossRefGoogle Scholar
Cerisuelo, A, Sala, R, Gasa, J, et al. (2010) Effects of increasing feed intake in mid-gestation over three successive rearing cycles on zootechnical performance and longevity of lean sows. Can J Anim Sci 90, 521528.CrossRefGoogle Scholar
Weldon, WC, Thulin, AJ, MacDougald, OA, et al. (1991) Effects of increased dietary energy and protein during late gestation on mammary development in gilts. J Anim Sci 69, 194200.CrossRefGoogle ScholarPubMed
Kim, SW (2010) Recent advances in sow nutrition. Rev Bras Zootec 39, 303310.CrossRefGoogle Scholar
Biensen, NJ, Wilson, ME & Ford, SP (1998) The impact of either a Meishan or Yorkshire uterus on Meishan or Yorkshire Fetal and placental development to days 70, 90, and 110 of gestation. J Anim Sci 76, 21692176.CrossRefGoogle Scholar
Ferreira, SV., Rodrigues, LA, Ferreira, MA, et al. (2021) Plane of nutrition during gestation affects reproductive performance and retention rate of hyperprolific sows under commercial conditions. Animal 15, 100153.CrossRefGoogle ScholarPubMed
de Araújo, VO, de Oliveira, RA, deVieira, MFA, et al. (2020) Bump feed for gestating sows is really necessary? Livest Sci 240, 104184.CrossRefGoogle Scholar
Cromwell, GL, Hall, DD, Clawson, AJ, et al. (1989) Effects of additional feed during late gestation on reproductive performance of sows: a cooperative study. J Anim Sci 67, 314.CrossRefGoogle ScholarPubMed
Shelton, NW, Neill, CR, DeRouchey, JM, et al. (2009) Effects of increasing feeding level during late gestation on sow and litter performance. Kansas Agric Exp Stn Res Reports 3850.Google Scholar
Mallmann, AL, Betiolo, FB, Camilloti, E, et al. (2018) Two different feeding levels during late gestation in gilts and sows under commercial conditions: impact on piglet birth weight and female reproductive performance. J Anim Sci 96, 42094219.CrossRefGoogle ScholarPubMed
Mallmann, AL, Camilotti, E, Fagundes, DP, et al. (2019) Impact of feed intake during late gestation on piglet birth weight and reproductive performance: a dose-response study performed in gilts. J Anim Sci 97, 12621272.CrossRefGoogle ScholarPubMed
Sinclair, AG, Bland, VC & Edwards, SA (2001) The influence of gestation feeding strategy on body composition of gilts at farrowing and response to dietary protein in a modified lactation. J Anim Sci 79, 23972405.CrossRefGoogle Scholar
Foisnet, A, Farmer, C, David, C, et al. (2010) Relationships between colostrum production by primiparous sows and sow physiology around parturition. J Anim Sci 88, 16721683.CrossRefGoogle ScholarPubMed
Eissen, JJ, Kanis, E & Kemp, B (2000) Sow factors affecting voluntary feed intake during lactation. Livest Prod Sci 64, 147165.CrossRefGoogle Scholar
Thaker, MYC & Bilkei, G (2005) Lactation weight loss influences subsequent reproductive performance of sows. Anim Reprod Sci 88, 309318.CrossRefGoogle ScholarPubMed
Ajuwon, KM, Arentson-Lantz, EJ & Donkin, SS (2016) Excessive gestational calorie intake in sows regulates early postnatal adipose tissue development in the offspring. BMC Nutr 2, 112.CrossRefGoogle Scholar
Wakabayashi, K, Okamura, M, Tsutsumi, S, et al. (2009) The peroxisome proliferator-activated receptor γ/Retinoid X receptor α heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 29, 35443555.CrossRefGoogle ScholarPubMed
Park, JR, Jung, JW, Lee, YS, et al. (2008) The roles of Wnt antagonists Dkk1 and sFRP4 during adipogenesis of human adipose tissue-derived mesenchymal stem cells. Cell Prolif 41, 859874.CrossRefGoogle ScholarPubMed
Ringold, GM, Chapman, AB & Knight, DM (1986) Glucocorticoid control of developmentally regulated adipose genes. J Steroid Biochem 24, 6975.CrossRefGoogle ScholarPubMed
Pawar, AS, Zhu, XY, Eirin, A, et al. (2015) Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity. Obesity 23, 399407.CrossRefGoogle Scholar
Hu, C, Yang, Y, Li, J, et al. (2019) Maternal diet-induced obesity compromises oxidative stress status and angiogenesis in the porcine placenta by upregulating Nox2 expression. Oxid Med Cell Longev 2019, 113.Google ScholarPubMed
Challier, JC, Basu, S, Bintein, T, et al. (2008) Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 29, 274281.CrossRefGoogle ScholarPubMed
Roberts, VHJ, Smith, J, McLea, SA, et al. (2009) Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta. Placenta 30, 169175.CrossRefGoogle ScholarPubMed
Xu, H, Barnes, GT, Yang, Q, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112, 18211830.CrossRefGoogle Scholar
Ajuwon, KM, Jacobi, SK & Kuske, JL (2004) Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-γ in primary pig adipocytes. Am J Physiol – Regul Integr Comp Physiol 286, 547553.CrossRefGoogle ScholarPubMed
Saben, J, Lindsey, F, Zhong, Y, et al. (2014) Maternal obesity is associated with a lipotoxic placental environment. Placenta 35, 171177.CrossRefGoogle ScholarPubMed
Gonzalez-Bulnes, A, Torres-Rovira, L, Ovilo, C, et al. (2012) Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance. Gen Comp Endocrinol 176, 94101.CrossRefGoogle Scholar
Fowden, AL, Camm, EJ & Sferruzzi-Perri, AN (2020) Effects of maternal obesity on placental phenotype. Curr Vasc Pharmacol 19, 113131.CrossRefGoogle Scholar
Algers, B & Uvnäs-Moberg, K (2007) Maternal behavior in pigs. Horm Behav 52, 7885.CrossRefGoogle ScholarPubMed
Szczubiał, M, Dabrowski, R, Bochniarz, M, et al. (2013) The influence of the duration of the expulsive stage of parturition on the occurrence of postpartum oxidative stress in sows with uncomplicated, spontaneous farrowings. Theriogenology 80, 706711.CrossRefGoogle ScholarPubMed
Björkman, S, Oliviero, C, Rajala-Schultz, PJ, et al. (2017) The effect of litter size, parity and farrowing duration on placenta expulsion and retention in sows. Theriogenology 92, 3644.CrossRefGoogle ScholarPubMed
Björkman, S, Oliviero, C, Kauffold, J, et al. (2018) Prolonged parturition and impaired placenta expulsion increase the risk of postpartum metritis and delay uterine involution in sows. Theriogenology 106, 8792.CrossRefGoogle ScholarPubMed
Peltoniemi, OAT, Björkman, S & Oliviero, C (2016) Parturition effects on reproductive health in the gilt and sow. Reprod Domest Anim 51, 3647.CrossRefGoogle ScholarPubMed
Oliviero, C, Kothe, S, Heinonen, M, et al. (2013) Prolonged duration of farrowing is associated with subsequent decreased fertility in sows. Theriogenology 79, 10951099.CrossRefGoogle ScholarPubMed
Langendijk, P & Plush, K (2019) Parturition and its relationship with stillbirths and asphyxiated piglets. Animals 9, 112.CrossRefGoogle ScholarPubMed
Rootwelt, V, Reksen, O, Farstad, W, et al. (2012) Associations between intrapartum death and piglet, placental, and umbilical characteristics. J Anim Sci 90, 42894296.CrossRefGoogle ScholarPubMed
McCracken, J, Custer, EE & Lamsa, JC (1999) Luteolysis: a neuroendocrine-mediated event. Physiol Rev 79, 263323.CrossRefGoogle ScholarPubMed
Russell, JA, Leng, G & Douglas, AJ (2003) The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy. Front Neuroendocrinol 24, 2761.CrossRefGoogle ScholarPubMed
Oliviero, C, Heinonen, M & Valros, A (2008) Effect of the environment on the physiology of the sow during late pregnancy, farrowing and early lactation. Anim Reprod Sci 105, 365377.CrossRefGoogle ScholarPubMed
Langendijk, P (2018) Prolonged duration of farrowing is related to a slow decline in progesterone before farrowing. In Proceedings of the 22nd European Society for Domestic Animals Reproduction. Berlin, Germany: Blackwell Verlag GmbH, pp. 27–29.Google Scholar
Mosnier, E, Etienne, M, Ramaekers, P, et al. (2010) The metabolic status during the peri partum period affects the voluntary feed intake and the metabolism of the lactating multiparous sow. Livest Sci 127, 127136.CrossRefGoogle Scholar
Hansen, A V, Lauridsen, C, Sorensen, MT, et al. (2012) Effects of nutrient supply, plasma metabolites, and nutritional status of sows during transition on performance in the next lactation. J Anim Sci 90, 466480.CrossRefGoogle ScholarPubMed
Feyera, T, Pedersen, TF, Krogh, U, et al. (2018) Impact of sow energy status during farrowing on farrowing kinetics, frequency of stillborn piglets, and farrowing assistance. J Anim Sci 96, 23202331.CrossRefGoogle ScholarPubMed
Le Cozler, Y, Beaumal, V, Neil, M, et al. (1999) Changes in the concentrations of glucose, non-esterifed fatty acids, urea, insulin, cortisol and some mineral elements in the plasma of the primiparous sow before, during and after induced parturition. Reprod Nutr Dev 39, 161169.CrossRefGoogle Scholar
Bories, P, Vautrin, F, Boulot, S, et al. (2010) Analysis of physiological and metabolic parameters associated with long or difficult farrowing in sows. Recherche 42, 233240.Google Scholar
Carnevale, RF, Muro, BBD, Carnino, BB, et al. (2020) Does glycemic concentration of the parturient sow affect farrowing kinetics? In Proceedings of International Pig Society Congress, p. 620.Google Scholar
Theil, PK (2015) Transition feeding of sows. In The Gestating and Lactating Sow. Chantal Farmer (Ed.). The Netherlands: Wageningen Academic Publishers, pp. 147172.CrossRefGoogle Scholar
Revell, DK, Williams, IH, Mullan, BP, et al. (1998) Body composition at farrowing and nutrition during lactation affect the performance of primiparous sows: I. Voluntary feed intake, weight loss, and plasma metabolites. J Anim Sci 76, 17291737.CrossRefGoogle ScholarPubMed
Weldon, WC, Lewis, AJ, Louis, GF, et al. (1994) Postpartum hypophagia in primiparous sows: I. Effects of gestation feeding level on feed intake, feeding behavior, and plasma metabolite concentrations during lactation. J Anim Sci 72, 387394.CrossRefGoogle ScholarPubMed
Feyera, T, Højgaard, CK, Vinther, J, et al. (2017) Dietary supplement rich in fiber fed to late gestating sows during transition reduces rate of stillborn piglets. J Anim Sci 95, 54305438.CrossRefGoogle Scholar
Bach Knudsen, KE & Hansen, I (1991) Gastrointestinal implications in pigs of wheat and oat fractions. Br J Nutr 65, 217232.CrossRefGoogle ScholarPubMed
Lindberg, JE (2014) Fiber effects in nutrition and gut health in pigs. J Anim Sci Biotechnol 5, 15.CrossRefGoogle ScholarPubMed
Serena, A, Jørgensen, H & Bach Knudsen, KE (2009) Absorption of carbohydrate-derived nutrients in sows as influenced by types and contents of dietary fiber. J Anim Sci 87, 136147.CrossRefGoogle ScholarPubMed
Feyera, T, Zhou, P, Nuntapaitoon, M, et al. (2019) Mammary metabolism and colostrogenesis in sows during late gestation and the colostral period. J Anim Sci 97, 231245.CrossRefGoogle ScholarPubMed
Serena, A, Jørgensen, H & Bach Knudsen, KE (2008) Digestion of carbohydrates and utilization of energy in sows fed diets with contrasting levels and physicochemical properties of dietary fiber. J Anim Sci 86, 22082216.CrossRefGoogle ScholarPubMed
Lavery, A, Lawlor, PG, Magowan, E, et al. (2019) An association analysis of sow parity, live-weight and back-fat depth as indicators of sow productivity. Animal 13, 622630.CrossRefGoogle ScholarPubMed
Amdi, C, Giblin, L, Hennessy, AA, et al. (2013) Feed allowance and maternal backfat levels during gestation influence maternal cortisol levels, milk fat composition and offspring growth. J Nutr Sci 2, 1.CrossRefGoogle ScholarPubMed
Hoffmann, CK & Bilkei, G (2003) Effect of body condition of postweaning‘flushed’ sows and weaning-tomating interval on sow reproductive performance. Vet Rec 152, 261263.CrossRefGoogle ScholarPubMed
Costermans, NGJ, Teerds, KJ, Keijer, J, et al. (2019) Follicular development of sows at weaning in relation to estimated breeding value for within-litter variation in piglet birth weight. Animal 13, 554563.CrossRefGoogle ScholarPubMed
Quesnel, H, Pasquier, A, Mounier, AM, et al. (1998) Influence of feed restriction during lactation on gonadotropic hormones and ovarian development in primiparous sows. J Anim Sci 76, 856863.CrossRefGoogle ScholarPubMed
Van Den Brand, H, Dieleman, SJ, Soede, NM, et al. (2000) Dietary energy source at two feeding levels during lactation of primiparous sows: I. Effects on glucose, insulin, and luteinizing hormone and on follicle development, weaning-to-estrus interval, and ovulation rate. J Anim Sci 78, 396404.CrossRefGoogle ScholarPubMed
Patterson, JL, Smit, MN, Novak, S, et al. (2011) Restricted feed intake in lactating primiparous sows. I. Effects on sow metabolic state and subsequent reproductive performance. Reprod Fertil Dev 23, 889898.CrossRefGoogle ScholarPubMed
Van den Brand, H, Soede, NM & Kemp, B (2006) Supplementation of dextrose to the diet during the weaning to estrus interval affects subsequent variation in within-litter piglet birth weight. Anim Reprod Sci 91, 353358.CrossRefGoogle Scholar
Chen, F, Wang, T, Feng, C, et al. (2015). Proteome differences in placenta and endometrium between normal and intrauterine growth restricted pig fetuses. PLoS One 10, e0142396.CrossRefGoogle ScholarPubMed
Wu, G, Bazer, FW, Johnson, GA, et al. (2017). Functional amino acids in the development of the pig placenta. Mol Reprod Dev 84, 870882.CrossRefGoogle ScholarPubMed
Prunier, A, Martin, C, Mounier, AM, et al. (1993) Metabolic and endocrine changes associated with undernutrition in the peripubertal gilt. J Anim Sci 71, 18871894.CrossRefGoogle ScholarPubMed
Van Wettere, WHEJ, Mitchell, M, et al. (2011) Nutritional restriction of pre-pubertal liveweight gain impairs ovarian follicle growth and oocyte developmental competence of replacement gilts. Theriogenology 75, 13011310.CrossRefGoogle ScholarPubMed
Szulc, K, Knecht, D, Jankowska-Makosa, A, et al. (2013) The influence of fattening and slaughter traits on reproduction in Polish Large White sows. Ital J Anim Sci 12, 1.CrossRefGoogle Scholar
Stalder, KJ, Saxton, AM, Conatser, GE, et al. (2005) Effect of growth and compositional traits on first parity and lifetime reproductive performance in U.S. Landrace sows. Livest Prod Sci 97, 151159.CrossRefGoogle Scholar
Nikkilä, MT, Stalder, KJ, Mote, BE, et al. (2013) Genetic associations for gilt growth, compositional, and structural soundness traits with sow longevity and lifetime reproductive performance. J Anim Sci 91, 15701579.CrossRefGoogle ScholarPubMed
Jin, SS, Jin, YH, Jang, JC, et al. (2018) Effects of dietary energy levels on physiological parameters and reproductive performance of gestating sows over three consecutive parities. Asian-Australas J Anim Sci 31, 410420.CrossRefGoogle ScholarPubMed
Da Silva-Buttkus, P, Van den Hurk, R, Velde, ER, et al. (2003) Ovarian development in intrauterine growth-retarded and normally developed piglets originating from the same litter. Reproduction 126, 249258.CrossRefGoogle ScholarPubMed
Estienne, MJ & Harper, AF (2010) Type of accommodation during gestation affects growth performance and reproductive characteristics of gilt offspring1. J Anim Sci 88, 400407.CrossRefGoogle Scholar
Freking, BA, Lents, CA & Vallet, JL (2016) Selection for uterine capacity improves lifetime productivity of sows. Anim Reprod Sci 167, 1621.CrossRefGoogle ScholarPubMed
Bee, G (2004) Effect of early gestation feeding, birth weight, and gender of progeny on muscle fiber characteristics of pigs at slaughter. J Anim Sci 82, 826836.CrossRefGoogle ScholarPubMed
Óvilo, C, González-Bulnes, A, Benítez, R, et al. (2014) Prenatal programming in an obese swine model: Sex-related effects of maternal energy restriction on morphology, metabolism and hypothalamic gene expression. Br J Nutr 111, 735746.CrossRefGoogle Scholar
Metges, CC, Lang, IS, Hennig, U, et al. (2012) Intrauterine growth retarded progeny of pregnant sows fed high protein: low carbohydrate diet is related to metabolic energy deficit. PLoS One 7, e31390.CrossRefGoogle ScholarPubMed
Wu, G, Bazer, FW, Wallace, JM, et al. (2006) Board-invited review: Intrauterine growth retardation: implications for the animal sciences. J Anim Sci 84, 23162337.CrossRefGoogle ScholarPubMed
Campos, PHRF, Silva, BAN, Donzele, JL, et al. (2012) Effects of sow nutrition during gestation on within-litter birth weight variation: a review. Animal 6, 797806.CrossRefGoogle ScholarPubMed
Prunier, A (1991) Influence of age at nutritional restriction on growth and sexual development of gilts. Reprod Nutr Dev 31, 647653.CrossRefGoogle ScholarPubMed
Miller, PS, Moreno, R & Johnson, RK (2011) Effects of restricting energy during the gilt developmental period on growth and reproduction of lines differing in lean growth rate: responses in feed intake, growth, and age at puberty. J Anim Sci 89, 342354.CrossRefGoogle ScholarPubMed
Ding, J & Foxcroft, GR (1992) Follicular heterogeneity and oocyte maturation in vitro in pigs1. Biol Reprod 47, 648655.CrossRefGoogle Scholar
Van De Leemput, EE, Vos, PLAM, Zeinstra, EC, et al. (1999) Improved in vitro embryo development using in vivo matured oocytes from heifers superovulated with a controlled preovulatory LH surge. Theriogenology 52, 335349.CrossRefGoogle ScholarPubMed
Ferguson, EM, Ashworth, CJ, Edwards, SA, et al. (2003) Effect of different nutritional regimens before ovulation on plasma concentrations of metabolic and reproductive hormones and oocyte maturation in gilts. Reproduction 126, 6171.CrossRefGoogle ScholarPubMed
Booth, PJ, Cosgrove, JR & Foxcroft, GR (1996) Endocrine and metabolic responses to realimentation in feed-restricted prepubertal gilts: associations among Gonadotropins, metabolic hormones, glucose, and uteroovarian development. J Anim Sci 74, 840848.CrossRefGoogle ScholarPubMed
Cosgrove, JR & Foxcroft, GR (1996) Nutrition and reproduction in the pig: ovarian aetiology. Anim Reprod Sci 42, 131141.CrossRefGoogle Scholar
Cosgrove, JR, Tilton, JE, Hunter, MG, et al. (1992) Gonadotropin-independent mechanisms participate in ovarian responses to realimentation in feed-restricted prepubertal gilts. Biol Reprod 47, 736745.CrossRefGoogle ScholarPubMed
Diskin, MG, Mackey, DR, Roche, JF, et al. (2003) Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim Reprod Sci 78, 345370.CrossRefGoogle ScholarPubMed
Butler, ST, Marr, AL, Pelton, SH, et al. (2003) Insulin restores GH responsiveness during lactation-induced negative energy balance in dairy cattle: effects on expression of IGF-I and GH receptor 1A. J. Endocrinol 176, 205217.CrossRefGoogle ScholarPubMed
Lubbers, ER, List, EO, Jara, A, et al. (2013) Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity. J Endocrinol 216, 363374.CrossRefGoogle ScholarPubMed
Tummaruk, P, Lundeheim, N, Einarsson, S, et al. (2001) Effect of birth litter size, birth parity number, growth rate, backfat thickness and age at first mating of gilts on their reproductive performance as sows. Anim Reprod Sci 66, 225237.CrossRefGoogle ScholarPubMed
Fleming, TP, Velazquez, MA, Eckert, JJ, et al. (2012) Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. Anim Reprod Sci 130, 193197.CrossRefGoogle ScholarPubMed
Burton, GJ & Jauniaux, E (2018) Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol 218, 745761.CrossRefGoogle ScholarPubMed
Ji, Y, Wu, Z, Dai, Z, et al. (2017) Fetal and neonatal programming of postnatal growth and feed efficiency in swine. J Anim Sci Biotechnol 8, 42.CrossRefGoogle ScholarPubMed
Yuan, Y & Krisher, RL (2010) Effect of ammonium during in vitro maturation on oocyte nuclear maturation and subsequent embryonic development in pigs. Anim Reprod Sci 117, 302307.CrossRefGoogle ScholarPubMed
Szymanska, M & Blitek, A (2016) Endometrial and conceptus response to exogenous progesterone treatment in early pregnant gilts following hormonally-induced estrus. Anim Reprod Sci 174, 5664.CrossRefGoogle ScholarPubMed
Athorn, RZ, Stott, P, Bouwman, EG, et al. (2013) Effect of feeding level on luteal function and progesterone concentration in the vena cava during early pregnancy in gilts. Reprod Fertil Dev 25, 531.CrossRefGoogle ScholarPubMed
Mwanza, A., Englund, P, Kindahl, H, et al. (2000) Effects of post-ovulatory food deprivation on the hormonal profiles, activity of the oviduct and ova transport in sows. Anim Reprod Sci 59, 185199.CrossRefGoogle ScholarPubMed
Rothschild, MF, Messer, L, Day, A, et al. (2000) Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mamm Genome 11, 7577.CrossRefGoogle ScholarPubMed
Xu, S-Y, Wu, D, Guo, H-Y, et al. (2009) The level of feed intake affects embryo survival and gene expression during early pregnancy in gilts. Reprod Domest Anim 45, 685693.Google ScholarPubMed
Franczak, A, Zglejc, K, Waszkiewicz, E, et al. (2017) Periconceptional undernutrition affects in utero methyltransferase expression and steroid hormone concentrations in uterine flushings and blood plasma during the peri-implantation period in domestic pigs. Reprod Fertil Dev 29, 14991508.CrossRefGoogle ScholarPubMed
Zglejc, K & Franczak, A (2017) Peri-conceptional under-nutrition alters the expression of TRIM28 and ZFP57 in the endometrium and embryos during peri-implantation period in domestic pigs. Reprod Domest Anim 52, 542550.CrossRefGoogle ScholarPubMed
Waclawik, A, Kaczmarek, MM, Blitek, A, et al. (2017) Embryo-maternal dialogue during pregnancy establishment and implantation in the pig. Mol Reprod Dev 84, 842855.CrossRefGoogle ScholarPubMed
Jeong, W, Song, G, Bazer, FW, et al. (2014) Insulin-like growth factor I induces proliferation and migration of porcine trophectoderm cells through multiple cell signaling pathways, including protooncogenic protein kinase 1 and mitogen-activated protein kinase. Mol Cell Endocrinol 384, 175184.CrossRefGoogle ScholarPubMed
Persson, E, Sahlin, L, Masironi, B, et al. (1997) Insulin-like growth factor-I in the porcine endometrium and placenta: localization and concentration in relation to steroid influence during early pregnancy. Anim Reprod Sci 46, 261281.CrossRefGoogle ScholarPubMed
Geisert, R (2002) Early embryonic survival in the pig: can it be improved? J Anim Sci 80, 5465.Google Scholar
Musser, RE, Davis, DL, Dritz, SS, et al. (2004) Conceptus and maternal responses to increased feed intake during early gestation in pigs12. J Anim Sci 82, 31543161.CrossRefGoogle Scholar
De, W, Ai-rong, Z, Yan, L, et al. (2009) Effect of feeding allowance level on embryonic survival, IGF-1, insulin, GH, leptin and progesterone secretion in early pregnancy gilts. J Anim Physiol Anim Nutr (Berl) 93, 577585.CrossRefGoogle ScholarPubMed
Leal, DF, Muro, BBD, Nichi, M, et al. (2019) Effects of post-insemination energy content of feed on embryonic survival in pigs: a systematic review. Anim Reprod Sci 205, 7077.CrossRefGoogle ScholarPubMed
Quesnel, H, Boulot, S, Serriere, S, et al. (2010) Post-insemination level of feeding does not influence embryonic survival and growth in highly prolific gilts. Anim Reprod Sci 120, 120124.CrossRefGoogle Scholar
Condous, PC, Kirkwood, RN, van Wettere, WHEJ (2014) The effect of pre- and post-mating dietary restriction on embryonic survival in gilts. Anim Reprod Sci 148, 130136.CrossRefGoogle ScholarPubMed
Hoving, LL, Soede, NM, Feitsma, H, et al. (2012) Embryo survival, progesterone profiles and metabolic responses to an increased feeding level during second gestation in sows. Theriogenology 77, 15571569.CrossRefGoogle Scholar
Kind, KL, Clifton, PM, Grant, PA, et al. (2003) Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig. Am J Physiol – Regul Integr Comp Physiol 284, 140152.CrossRefGoogle ScholarPubMed
Close, WH, Noblet, J & Heavens, RP (1985) Studies on the energy metabolism of the pregnant sow. Br J Nutr 53, 267279.CrossRefGoogle ScholarPubMed
Lesage, J, Blondeau, B, Grino, M, et al. (2001) Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 142, 16921702.CrossRefGoogle ScholarPubMed
Belkacemi, L, Jelks, A, Chen, CH, et al. (2011) Altered placental development in undernourished rats: role of maternal glucocorticoids. Reprod Biol Endocrinol 9, 105.CrossRefGoogle ScholarPubMed
Vickers, MH, Breier, BH, Cutfield, WS, et al. (2000) Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol – Endocrinol Metab 279, 8387.CrossRefGoogle ScholarPubMed
Desai, M, Gayle, D, Han, G, et al. (2007) Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring. Reprod Sci 14, 329337.CrossRefGoogle ScholarPubMed
Ikenasio-Thorpe, BA, Breier, BH, Vickers, MH, et al. (2007) Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression. J Endocrinol 193, 3137.CrossRefGoogle ScholarPubMed
Krechowec, SO, Vickers, M, Gertler, A, et al. (2006) Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity. J Endocrinol 189, 355363.CrossRefGoogle ScholarPubMed
Plagemann, A, Waas, T, Harder, T, et al. (2000) Hypothalamic neuropeptide Y levels in weaning offspring of low-protein malnourished mother rats. Neuropeptides 34, 16.CrossRefGoogle ScholarPubMed
Orozco-Solís, R, Matos, RJB, Guzmán-Quevedo, O, et al. (2010) Nutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus. PLoS One 5, e13537.CrossRefGoogle ScholarPubMed
Theil, PK, Sorensen, IL, Nissen, PM, et al. (2006) Temporal expression of growth factor genes of primary porcine satellite cells during myogenesis. Anim Sci J 77, 330337.CrossRefGoogle Scholar
Tuchscherer, M, Otten, W, Kanitz, E, et al. (2012) Effects of inadequate maternal dietary protein: carbohydrate ratios during pregnancy on offspring immunity in pigs. BMC Vet Res 8, 232.CrossRefGoogle ScholarPubMed
Wu, G, Pond, WG, Ott, T, et al. (1998) Maternal dietary protein deficiency decreases amino acid concentrations in fetal plasma and allantoic fluid of pigs. J Nutr 2, 894902.CrossRefGoogle Scholar
Rehfeldt, C, Nissen, PM & Kuhn, G (2004) Effects of maternal nutrition and porcine growth hormone (pGH) treatment during gestation on endocrine and metabolic factors in sows, fetuses and pigs, skeletal muscle development, and postnatal growth. Domest Anim Endocrinol 27, 267285.CrossRefGoogle ScholarPubMed
Zou, T, Yu, B, Yu, J, et al. (2016) Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs. Genes Nutr 11, 110.CrossRefGoogle ScholarPubMed
Cao, M, Che, L, Wang, J, et al. (2014) Effects of maternal over- and undernutrition on intestinal morphology, enzyme activity, and gene expression of nutrient transporters in newborn and weaned pigs. Nutrition 30, 14421447.CrossRefGoogle ScholarPubMed
Noblet, J, Dourmad, JY, Etienne, M, et al. (1997) Energy metabolism in pregnant sows and newborn pigs. J Anim Sci 75, 2708.CrossRefGoogle ScholarPubMed
Dividich, J LE, Rooke, JA & Herpin, P (2005) Nutritional and immunological importance of colostrum for the new-born pig. J Agric Sci 143, 469485.CrossRefGoogle Scholar
Hales, J, Moustsen, VA, Nielsen, MBF, et al. (2014). Higher preweaning mortality in free farrowing pens compared with farrowing crates in three commercial pig farms. Animal 8, 113120.CrossRefGoogle ScholarPubMed
Decaluwé, R, Maes, D, Wuyts, B, et al. (2014) Piglets’ colostrum intake associates with daily weight gain and survival until weaning. Livest Sci 162, 185192.CrossRefGoogle Scholar
Hasan, S, Orro, T, Valros, A, et al. (2019) Factors affecting sow colostrum yield and composition, and their impact on piglet growth and health. Livest Sci 227, 6067.CrossRefGoogle Scholar
Beyga, K & Rekiel, A (2009) Effect of the backfat thickness of sows in late pregnancy on the composition of colostrum and milk. Arch Anim Breed 52, 593602.CrossRefGoogle Scholar
Dourmad, JY, Noblet, J & Étienne, M (1998) Effect of protein and lysine supply on performance, nitrogen balance, and body composition changes of sows during lactation. J Anim Sci 76, 542550.CrossRefGoogle ScholarPubMed
Nelssen, JL, Lewis, AJ, Peo, ER, et al. (1982) Effect of dietary energy intake during lactation on performance of primiparous sows and their litters. J Anim Sci 61, 11641171.CrossRefGoogle Scholar
Koketsu, Y, Dial, GD, Pettigrew, JE, et al. (1996) Characterization of feed intake patterns during lactation in commercial swine herds. J Anim Sci 74, 12021210.CrossRefGoogle ScholarPubMed
Grandinson, K, Rydhmer, L, Strandberg, E, et al. (2005) Genetic analysis of body condition in the sow during lactation, and its relation to piglet survival and growth. Anim Sci 80, 3340.CrossRefGoogle Scholar
Eissen, JJ, Apeldoorn, EJ, Kanis, E, et al. (2003) The importance of a high feed intake during lactation of primiparous sows nursing large litters. J Anim Sci 81, 594603.CrossRefGoogle ScholarPubMed
Hoving, LL, Soede, NM, van der Peet-Schwering, CMC, et al. (2011) An increased feed intake during early pregnancy improves sow body weight recovery and increases litter size in young sows. J Anim Sci 89, 35423550.CrossRefGoogle ScholarPubMed
Lucia, T, Dial, GD & Marsh, WE (2000) Lifetime reproductive and financial performance of female swine. J Am Vet Med Assoc 216, 18021809.CrossRefGoogle ScholarPubMed
Sasaki, Y & Koketsu, Y (2008) Mortality, death interval, survivals, and herd factors for death in gilts and sows in commercial breeding herds. J Anim Sci 86, 31593165.CrossRefGoogle ScholarPubMed
Hazeleger, W, Soede, NM & Kemp, B (2005) The effect of feeding strategy during the pre-follicular phase on subsequent follicular development in the pig. Domest Anim Endocrinol 29, 362370.CrossRefGoogle ScholarPubMed
Soede, NM, Langendijk, P & Kemp, B (2011) Reproductive cycles in pigs. Anim Reprod Sci 124, 251258.CrossRefGoogle ScholarPubMed
Prunier, A & Quesnel, H (2000) Nutritional influences on the hormonal control of reproduction in female pigs. Livest Prod Sci 63, 116.CrossRefGoogle Scholar
Zak, LJ, Cosgrove, JR, Aherne, FX, et al. (1997) Pattern of feed intake and associated metabolic and endocrine changes differentially affect postweaning fertility in primiparous lactating sows. J Anim Sci 75, 208216.CrossRefGoogle ScholarPubMed
Van den Brand, H, van Enckevort, L, van der Hoeven, E, et al. (2009). Effects of dextrose plus lactose in the Sows diet on subsequent reproductive performance and within litter birth weight variation. Reprod Domest Anim 44, 884888.CrossRefGoogle ScholarPubMed
Wientjes, JGM, Soede, NM, Knol, EF, et al. (2013) Piglet birth weight and litter uniformity: effects of weaning-to-pregnancy interval and body condition changes in sows of different parities and crossbred lines. J Anim Sci 91, 20992107.CrossRefGoogle ScholarPubMed
Coffey, RD, Parker, GP & Laurent, KM (1999) Assessing sow body condition. Ky. Coop. Ext. Serv. Rep. No. ASC-158. http://www2.ca.uky.edu/agcomm/pubs/asc/asc158/asc158.pdf (accessed 07 May 2021).Google Scholar