In contrast to homeostasis, allostasis refers to the relatively new idea of "viability through change." This book addresses basic physiological regulatory systems, and examines bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will interest graduate students, medical students, and researchers in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
Contents
1. Principles of allostasis: optimal design, predictive regulation, pathophysiology and rational therapeutics Peter Sterling; 2. Protection and damaging effects of the mediators of stress and adaptation: allostasis and allostatic load Bruce S. McEwen; 3. Merging of the homeostatic theory with the concept of allostatic load David S. Goldstein; 4. Operationalizing allostatic load Burton Singer, Carol D. Ryff and Teresa Seeman; 5. Drug addiction and allostasis George F. Koob and Michael LeMoal; 6. Adaptive fear and the pathology of anxiety and depression: an allostatic framework Jeffrey B. Rosen and Jay Schulkin; 7. A chronobiological perspective on allostasis and its application to shift work Ziad Boulos and Alan M. Rosenwasser; 8. Allostatic load and life cycles: implications for neuroendocrine control mechanisms John C. Wingfield; 9. Commentary: viability as opposed to stability: an evolutionary perspective on physiological regulation Michael L. Power.
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