Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- Part II Cell Death in Tissues and Organs
- 11 Cell Death in Nervous System Development and Neurological Disease
- 12 Role of Programmed Cell Death in Neurodegenerative Disease
- 13 Implications of Nitrosative Stress-Induced Protein Misfolding in Neurodegeneration
- 14 Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia
- 15 Cell Death in Spinal Cord Injury – An Evolving Taxonomy with Therapeutic Promise
- 16 Apoptosis and Homeostasis in the Eye
- 17 Cell Death in the Inner Ear
- 18 Cell Death in the Olfactory System
- 19 Contribution of Apoptosis to Physiologic Remodeling of the Endocrine Pancreas and Pathophysiology of Diabetes
- 20 Apoptosis in the Physiology and Diseases of the Respiratory Tract
- 21 Regulation of Cell Death in the Gastrointestinal Tract
- 22 Apoptosis in the Kidney
- 23 Physiologic and Pathological Cell Death in the Mammary Gland
- 24 Therapeutic Targeting Apoptosis in Female Reproductive Biology
- 25 Apoptotic Signaling in Male Germ Cells
- 26 Cell Death in the Cardiovascular System
- 27 Cell Death Regulation in Muscle
- 28 Cell Death in the Skin
- 29 Apoptosis and Cell Survival in the Immune System
- 30 Cell Death Regulation in the Hematopoietic System
- 31 Apoptotic Cell Death in Sepsis
- 32 Host–Pathogen Interactions
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
23 - Physiologic and Pathological Cell Death in the Mammary Gland
from Part II - Cell Death in Tissues and Organs
Published online by Cambridge University Press: 07 September 2011
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- Part II Cell Death in Tissues and Organs
- 11 Cell Death in Nervous System Development and Neurological Disease
- 12 Role of Programmed Cell Death in Neurodegenerative Disease
- 13 Implications of Nitrosative Stress-Induced Protein Misfolding in Neurodegeneration
- 14 Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia
- 15 Cell Death in Spinal Cord Injury – An Evolving Taxonomy with Therapeutic Promise
- 16 Apoptosis and Homeostasis in the Eye
- 17 Cell Death in the Inner Ear
- 18 Cell Death in the Olfactory System
- 19 Contribution of Apoptosis to Physiologic Remodeling of the Endocrine Pancreas and Pathophysiology of Diabetes
- 20 Apoptosis in the Physiology and Diseases of the Respiratory Tract
- 21 Regulation of Cell Death in the Gastrointestinal Tract
- 22 Apoptosis in the Kidney
- 23 Physiologic and Pathological Cell Death in the Mammary Gland
- 24 Therapeutic Targeting Apoptosis in Female Reproductive Biology
- 25 Apoptotic Signaling in Male Germ Cells
- 26 Cell Death in the Cardiovascular System
- 27 Cell Death Regulation in Muscle
- 28 Cell Death in the Skin
- 29 Apoptosis and Cell Survival in the Immune System
- 30 Cell Death Regulation in the Hematopoietic System
- 31 Apoptotic Cell Death in Sepsis
- 32 Host–Pathogen Interactions
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
Summary
Introduction
Apoptosis is a regulated cell suicide program that functions to control mitosis during the development and maintenance of tissues. This type of cell death plays a key role in the extensive postnatal development of the breast. Dysregulation in apoptosis has been speculated to contribute to hyperplasia and to promote breast cancer and resistance to chemotherapy. Recent studies have highlighted that other modes of cell death additionally influence breast development, tumorigenesis, or response to chemotherapy. This chapter reviews the role and regulation of apoptosis in the normal and neoplastic breast. It also briefly summarizes the contribution of other types of cell death, such as autophagy, necrosis, or entosis.
- Type
- Chapter
- Information
- ApoptosisPhysiology and Pathology, pp. 250 - 272Publisher: Cambridge University PressPrint publication year: 2011