Book contents
- Frontmatter
- Contents
- Preface
- Foreword
- List of contributors
- 1 Coated vesicles: a morphologically distinct subclass of endocytic vesicles
- 2 Coated vesicles in different cell types: some functional implications
- 3 Coated vesicles: their occurrence in different plant cell types
- 4 Immunoglobulin transmission in mammalian young and the involvement of coated vesicles
- 5 Coated vesicles in neurons
- 6 Coated vesicles in the oocyte
- 7 Adsorptive and passive pinocytic uptake
- 8 Coated vesicles and receptor biology
- 9 Coated secretory vesicles
- 10 Dynamic aspects of coated vesicle function
- 11 Structural aspects of coated vesicles at the molecular level
- 12 Coated vesicles in medical science
- Appendix 1 Nomenclature
- Appendix 2 References added at proof
- Author index
- Subject index
- Plate section
12 - Coated vesicles in medical science
Published online by Cambridge University Press: 04 August 2010
- Frontmatter
- Contents
- Preface
- Foreword
- List of contributors
- 1 Coated vesicles: a morphologically distinct subclass of endocytic vesicles
- 2 Coated vesicles in different cell types: some functional implications
- 3 Coated vesicles: their occurrence in different plant cell types
- 4 Immunoglobulin transmission in mammalian young and the involvement of coated vesicles
- 5 Coated vesicles in neurons
- 6 Coated vesicles in the oocyte
- 7 Adsorptive and passive pinocytic uptake
- 8 Coated vesicles and receptor biology
- 9 Coated secretory vesicles
- 10 Dynamic aspects of coated vesicle function
- 11 Structural aspects of coated vesicles at the molecular level
- 12 Coated vesicles in medical science
- Appendix 1 Nomenclature
- Appendix 2 References added at proof
- Author index
- Subject index
- Plate section
Summary
Coated vesicles varying considerably in morphology have been described in various types of cells and a survey of the literature leads one to consider it probable that more than one functional entity has been given this name. Friend & Farquhar (1967) in a widely quoted paper present evidence for two types of coated vesicles in the rat vas deferens: a large type (> 100 nm in diameter) which they equate with heterophagosomes and to which they ascribe the functions of protein uptake and membrane resorption, and a smaller variety (< 75 nm in diameter) which they consider to be primary lysosomes. Kallio, Garant & Minkin (1971) described the ruffled border of active osteoclasts in fish and rats. They drew attention to deep imaginations and villous extensions of the plasma membrane which possess a coat of repeating units along their cytoplasmic surface. The presence of numerous smooth-walled and coated vesicles in the cytoplasm deep to the ruffled border was also noted. The authors suggest that the participate coat on the surface cytoplasmic membrane may be of a different nature to that present on the coated vesicles. Tangential sections of the coating on the cytoplasmic aspect of the surface membrane failed to reveal the polygonal pattern characteristic of the coated vesicles in the apical cytoplasm and it was thought possible that while the coated vesicles played a part in protein resorption, the particles on the ruffled border may represent sites of enzymatic activity connected with bone demineralisation.
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- Information
- Coated Vesicles , pp. 303 - 318Publisher: Cambridge University PressPrint publication year: 1980