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2 - Pathology for the radiologist: pathological insights into colorectal cancer

Published online by Cambridge University Press:  07 September 2010

Philip Quirke
Affiliation:
Gastrointestinal Cancer Research Group Pathology and Tumour Biology Yorkshire Cancer Research and Liz Dawn Translational Science Centre Leeds Institute of Molecular Medicine Wellcome Trust Brenner Building St James University Hospital Becket Street Leeds LS9 7TF UK
Gina Brown
Affiliation:
Royal Marsden Hospital
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Colorectal Cancer , pp. 15 - 33
Publisher: Cambridge University Press
Print publication year: 2007

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References

Blomqvist, L., Rubio, C., Holm, T., Machado, M., and Hindmarsh, T.Rectal adenocarcinoma: assessment of tumour involvement of the lateral resection margin by MRI of the resected specimen. Br J Radiol, 72 (1999), 18–23.CrossRefGoogle ScholarPubMed
Brown, G., Richards, C. J., Newcombe, R. G., et al. Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology, 211 (1999), 215–22.CrossRefGoogle ScholarPubMed
Brown, G., Radcliffe, A. G., Newcombe, R. G., et al. Preoperative assessment of prognostic factors in rectal cancer using high resolution magnetic resonance imaging. Br J Surg, 90 (2003), 355–64.CrossRefGoogle ScholarPubMed
Extramural depth of tumour invasion at their section MR in patients with rectal cancer: Results of the mercury trial. Radiology, 243 (2007), 132–9.CrossRef
Quirke, P., Durdey, P., Dixon, M. F., and Williams, N. S.Local recurrence of rectal adenocarcinoma is caused by inadequate surgical resection: histopathological study of lateral tumour spread and surgical excision. Lancet, ii (1986), 996–9.CrossRefGoogle Scholar
Ng, I. O., Luk, I. S., Yuen, S. T., et al. Surgical lateral clearance in resected rectal carcinomas: a multivariate analysis of clinicopathological features. Cancer, 71 (1993), 1972–6.3.0.CO;2-V>CrossRefGoogle Scholar
Adam, I. J., Mohamdee, M. O., Martin, I. G., et al. Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet, 344 (1994), 707–11.CrossRefGoogle ScholarPubMed
Haas-Koch, D. F., Baeten, C. G. M. I., Jager, J. J., et al. Prognostic significance of radial margins of clearance in rectal carcinoma. Br J Surg, 83 (1996), 781–5.CrossRefGoogle Scholar
Birbeck, K. F., Macklin, C. P., Tiffin, N. J., et al. Rates of circumferential margin involvement vary between surgeons and predict outcomes in rectal cancer surgery. Ann Surg, 235:4 (2002), 449–57.CrossRefGoogle ScholarPubMed
Wibe, A., Rendedal, P. R., Svensson, E., Norstein, J., Eide, T. J., Myrvold, H. E., Soreide, O. on behalf of the Norwegian Rectal Cancer Group. Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg, 89 (2002), 327–34.CrossRefGoogle ScholarPubMed
Nagtegaal, I. D., Marijnen, C. A. M., Kranenbarg, E. K., Velde, C. J. H., and Krieken, J. H. J. M.Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma. Not one millimetre but two millimetres is the limit. Am J Surg Pathol, 26 (2002), 350–7.CrossRefGoogle ScholarPubMed
Maughan, N. J., Morris, E., Craig, S. C., et al. Analysis of Northern and Yorkshire Cancer Registry Data 1995–2001. J Pathol, 201:suppl. (2003), 18A.Google Scholar
Martling, A., Singnomklao, T., Holm, T., Rutqvist, L. E., and Cedermark, B.Prognostic significance of both surgical and pathological assessment of curative resection for rectal cancer. Br J Surg, 91 (2004), 1040–5.CrossRefGoogle ScholarPubMed
Wibe, A., Syse, A., Andersen, E., Tredi, S., Myrvold, H. E., Soreide, O. on behalf of the Norwegian Rectal Cancer Group. Oncological outcomes after total mesorectal excision for cure for cancer of the lower rectum: anterior resection vs abdominoperineal resection. Dis Colon Rectum 47 (2004), 48–58.CrossRefGoogle ScholarPubMed
Marr, R., Birbeck, K., Garvican, J., et al. The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg, 242:1 (July 2005), 74–82.CrossRefGoogle ScholarPubMed
Martling, A., Holm, T., Bremmner, S., et al. Prognostic value of preoperative magnetic resonance imaging of the pelvis in rectal cancer. Br J Surg, 90 (2003), 1422–8.CrossRefGoogle ScholarPubMed
Kim, C. K., Kim, S. H., Chun, K. H., et al. Preoperative staging of rectal cancer: accuracy of 3-Tesla magnetic resonance imaging. Eur Radiol, 16 (2006), 972–80.CrossRefGoogle ScholarPubMed
Syk, E., Torkzad, M. R., Blomqvist, L., Ljungqvist, O., and Glimelius, B.Radiological findings do not support lateral residual tumour as a major cause of local recurrence of rectal cancer. Br J Surg, 93 (2006), 113–19.CrossRefGoogle Scholar
Torkzad, M. R. and Blomqvist, L.The mesorectum: morphometric assessment with magnetic resonance imaging. Eur Radiol, 15 (2005), 1184–91.CrossRefGoogle ScholarPubMed
Boyle, K. M., Petty, D., Chalmers, A. G., et al. MRI assessment of the bony pelvis may help predict resectability of the rectal cancer. Colorect Dis, 7 (2005), 232–40.CrossRefGoogle ScholarPubMed
Nagtegaal, I. D., Velde, C. J. H., Marijnen, C. A. M., Krieken, J. H. J. M., and Quirke, P. for the pathology review committee and the cooperative clinical investigators of the Dutch Colorectal Cancer Group. Low rectal cancer; a call for a change of approach in abdominoperineal resection. J Clin Oncol, 23:36 (2005), 9257–64.CrossRefGoogle Scholar
Howarth, S. M., Morgan, J. M., and Williams, G. T.The new (6th edition) TNM classification of colorectal cancer a stage too far. Gut, 53 (2004), A21.Google Scholar
Kapiteijn, E., Marijnen, C. A. M., Nagtegaal, I. D., Putten, H., Steup, W. H., Wiggers, T., Rutten, H., Pahlman, L., Glimelius, B., Krieken, H. J. M., Leer, J. W. H., Velde, C. J. H. for the Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for respectable rectal cancer. N Engl J Med, 345 (2001), 638–46.CrossRefGoogle Scholar
Guillou, P., Quirke, P., Thorpe, H., Walker, J., Jayne, D., Smith, A. M. H., Heath, R. M., Brown, J. M. for the MRC CLASICC Trial Group. Short-term endpoints of conventional versus laparoscopic assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet, 365 (2005), 1718–26.CrossRefGoogle ScholarPubMed
Quirke, P., Sebag-Montefiore, D., Steele, R., Khanna, S., Monson, J., Holliday, A., Thompson, L., Griffiths, G., Stephanie, R., on behalf of all the CR07 participants. Local recurrence after rectal cancer resection is strongly related to the plane of surgical dissection and is further reduced by pre-operative short course radiotherapy. J Clin Oncol, 24 (2006), Part I suppl 1495.Google Scholar
Nagtegaal, I. D., Marijnen, C. A. M., Kranebarg, E. K., et al. Pathology Review Committee. Short term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer. J Pathol, 197 (2002), 20–7.CrossRefGoogle ScholarPubMed
Mawdsley, S., Glynne-Jones, R., Grainger, J., et al. Can the histopathological assessment of the circumferential margin following pre-operative pelvic chemo-radiotherapy for T3/4 rectal cancer predict for three year disease free survival?Int J Radiation Oncol, 63 (2005), 745–52.CrossRefGoogle Scholar
Sebag-Montefiore, D., Glynne-Jones, R., Mortensen, N., et al. Pooled analysis of outcome measures including the histopathological R0 resection rate after preoperative chemoradiation for locally advanced rectal cancer. Colorect Dis, 7:suppl. 22 (2005), A20.Google Scholar
Sebag-Montefiore, D., Hingorani, M., Cooper, R., and Chesser, P. Circumferential resection margin status predicts outcome after pre-operative chemoradiation for locally advanced rectal cancer. http://www.asco.org/ac/1,003,12-002636-0018-0036-00190010208.00.asp.
Luna-Perez, P., Bustos-Cholico, E., Alvarado, I., et al. Prognostic significance of circumferential margin involvement in rectal adenocarcinoma treated with preoperative chemoradiotherapy and low anterior resection. J Surg Oncol, 90 (2005), 20–5.CrossRefGoogle ScholarPubMed
Rodel, C., Martus, P., Papadoupolos, T., et al. Prognostic significance of tumour regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol, 23 (2005), 8688–96.CrossRefGoogle ScholarPubMed
Mandard, A. M., Dalibard, F., Mandard, J. C., et al. Pathological assessment of tumour regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathological correlations. Cancer, 73 (1994), 2680–6.3.0.CO;2-C>CrossRefGoogle Scholar
Dworak, O., Keilholtz, L., and Hoffmann, A.Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorect Dis, 12 (1997), 19–23.CrossRefGoogle ScholarPubMed
Bouzourene, H., Bosman, F. T., Seelentag, W., Matter, M., and Coucke, P.Importance of tumour regression assessment in predicting outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer, 94 (2002), 1121–30.CrossRefGoogle ScholarPubMed
Petersen, V. C., Baxter, K. J., Love, S. B., and Shepherd, N. A.Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer. Gut, 51 (2002), 65–9.CrossRefGoogle ScholarPubMed
Ludeman, L. and Shepherd, N. A.Serosal involvement in gastrointestinal cancer: its assessment and significance. Histopathology, 47 (2005), 123–31.CrossRefGoogle ScholarPubMed
Bateman, A. C., Carr, N. J., and Warren, B. F.The retroperitoneal surface in distal caecal and proximal ascending colon carcinoma: the Cinderella surgical margin?J Clin Pathol, 58:4 (April 2005), 426–8.CrossRefGoogle ScholarPubMed

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  • Pathology for the radiologist: pathological insights into colorectal cancer
    • By Philip Quirke, Gastrointestinal Cancer Research Group Pathology and Tumour Biology Yorkshire Cancer Research and Liz Dawn Translational Science Centre Leeds Institute of Molecular Medicine Wellcome Trust Brenner Building St James University Hospital Becket Street Leeds LS9 7TF UK
  • Edited by Gina Brown
  • Book: Colorectal Cancer
  • Online publication: 07 September 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511902468.003
Available formats
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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Pathology for the radiologist: pathological insights into colorectal cancer
    • By Philip Quirke, Gastrointestinal Cancer Research Group Pathology and Tumour Biology Yorkshire Cancer Research and Liz Dawn Translational Science Centre Leeds Institute of Molecular Medicine Wellcome Trust Brenner Building St James University Hospital Becket Street Leeds LS9 7TF UK
  • Edited by Gina Brown
  • Book: Colorectal Cancer
  • Online publication: 07 September 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511902468.003
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Pathology for the radiologist: pathological insights into colorectal cancer
    • By Philip Quirke, Gastrointestinal Cancer Research Group Pathology and Tumour Biology Yorkshire Cancer Research and Liz Dawn Translational Science Centre Leeds Institute of Molecular Medicine Wellcome Trust Brenner Building St James University Hospital Becket Street Leeds LS9 7TF UK
  • Edited by Gina Brown
  • Book: Colorectal Cancer
  • Online publication: 07 September 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511902468.003
Available formats
×