Book contents
- Common Pitfalls in Cognitive and Behavioral Neurology
- Common Pitfalls in Cognitive and Behavioral Neurology
- Copyright page
- Dedication
- Contents
- Diseases Discussed in the Book
- Preface
- Acknowledgements
- Abbreviations
- Part 1 Missing the Diagnosis Altogether
- Part 2 Misidentifying the Impaired Cognitive Domain
- Part 3 Missing Important Clues in the History
- Part 4 Failure of Pattern Recognition
- Part 5 Difficult-to-Characterize Cognitive/Behavioral Disorders
- Part 6 Clinical Findings That Are Subtle
- Part 7 Misinterpreting Test Results
- Part 8 Attributing Findings to a Known or Suspected Disorder
- Part 9 Missing Radiographic Clues
- Case 41 Another Case of Vascular Cognitive Impairment?
- Case 42 Pseudoatrophic Pattern in Hydrocephalus
- Case 43 Parkinsonism, Ataxia, and Cognitive Impairment after Radiation Therapy
- Case 44 It’s Not Alzheimer Disease; Now What?
- Case 45 Getting the Full Picture
- Part 10 Management Misadventures
- Index
- Plate Section (PDF Only)
- References
Case 43 - Parkinsonism, Ataxia, and Cognitive Impairment after Radiation Therapy
from Part 9 - Missing Radiographic Clues
Published online by Cambridge University Press: 03 November 2020
Book contents
- Common Pitfalls in Cognitive and Behavioral Neurology
- Common Pitfalls in Cognitive and Behavioral Neurology
- Copyright page
- Dedication
- Contents
- Diseases Discussed in the Book
- Preface
- Acknowledgements
- Abbreviations
- Part 1 Missing the Diagnosis Altogether
- Part 2 Misidentifying the Impaired Cognitive Domain
- Part 3 Missing Important Clues in the History
- Part 4 Failure of Pattern Recognition
- Part 5 Difficult-to-Characterize Cognitive/Behavioral Disorders
- Part 6 Clinical Findings That Are Subtle
- Part 7 Misinterpreting Test Results
- Part 8 Attributing Findings to a Known or Suspected Disorder
- Part 9 Missing Radiographic Clues
- Case 41 Another Case of Vascular Cognitive Impairment?
- Case 42 Pseudoatrophic Pattern in Hydrocephalus
- Case 43 Parkinsonism, Ataxia, and Cognitive Impairment after Radiation Therapy
- Case 44 It’s Not Alzheimer Disease; Now What?
- Case 45 Getting the Full Picture
- Part 10 Management Misadventures
- Index
- Plate Section (PDF Only)
- References
Summary
This 60-year-old woman presented with a 6-year history of bilateral hand tremor and progressive gait impairment. She first noticed bilateral hand tremor when holding objects, followed by balance impairment, slow walking with foot dragging, and a tendency to fall forward. Within four years, she required a wheelchair for ambulation. She endorsed initial short-term memory affecting her ability to process information, which accelerated in the last year. Two years prior to the onset of her symptoms she had received chemotherapy (carboplatin and etoposide) with prophylactic whole-brain radiation as treatment for lung cancer.
- Type
- Chapter
- Information
- Common Pitfalls in Cognitive and Behavioral NeurologyA Case-Based Approach, pp. 137 - 140Publisher: Cambridge University PressPrint publication year: 2020
References
Apartis, E. et al. 2012. FXTAS: new insights and the need for revised diagnostic criteria. Neurology 79(18) 1898–1907.CrossRefGoogle ScholarPubMed
Brunberg, J. A. et al. 2002. Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction. AJNR Am J Neuroradiol 23(10) 1757–1766.Google ScholarPubMed
Greene-Schloesser, D. et al. 2012. Radiation-induced brain injury: a review. Front Oncol 2 73.CrossRefGoogle ScholarPubMed
Grigsby, J. et al. 2014. The cognitive neuropsychological phenotype of carriers of the FMR1 premutation. J Neurodev Disord 6(1) 28.Google Scholar
Hagerman, P. 2013. Fragile X–associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms. Acta Neuropathol 126(1) 1–19.Google Scholar
Hagerman, R. J. and Hagerman, P. 2016. Fragile X–associated tremor/ataxia syndrome – features, mechanisms and management. Nat Rev Neurol 12(7) 403–412.CrossRefGoogle ScholarPubMed
Hagerman, R. J. et al. 2001. Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. Neurology 57(1) 127–130.CrossRefGoogle ScholarPubMed
Hall, D. A. et al. 2014. Emerging topics in FXTAS. J Neurodev Disord 6(1) 31.CrossRefGoogle ScholarPubMed
Leehey, M. A. 2009. Fragile X–associated tremor/ataxia syndrome: clinical phenotype, diagnosis, an treatment. J Investig Med 57(8) 830–836.CrossRefGoogle Scholar
Leehey, M. A. et al. 2008. FMR1 CGG repeat length predicts motor dysfunction in premutation carriers. Neurology 70(16 Pt 2) 1397–1402.CrossRefGoogle ScholarPubMed
Leehey, M. A. et al. 2007. Progression of tremor and ataxia in male carriers of the FMR1 premutation. Mov Disord 22(2) 203–206.Google Scholar
Seltzer, M. M. et al. 2012. Prevalence of CGG expansions of the FMR1 gene in a US population-based sample. Am J Med Genet B Neuropsychiatr Genet 159b(5) 589–597.CrossRefGoogle Scholar
Seritan, A., Cogswell, J. and Grigsby, J. 2013. Cognitive dysfunction in FMR1 premutation carriers. Curr Psychiatry Rev 9(1) 78–84.Google ScholarPubMed
Seritan, A. L. et al. 2008. Dementia in fragile X–associated tremor/ataxia syndrome (FXTAS): comparison with Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet 147b(7) 1138–1144.CrossRefGoogle ScholarPubMed
Tassone, F. et al. 2012. Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS. Genes Brain Behav 11(5) 577–585.CrossRefGoogle ScholarPubMed
Yang, J. C. et al. 2014. ERP abnormalities elicited by word repetition in fragile X–associated tremor/ataxia syndrome (FXTAS) and amnestic MCI. Neuropsychologia 63 34–42.Google Scholar