Book contents
- Common Pitfalls in Cognitive and Behavioral Neurology
- Common Pitfalls in Cognitive and Behavioral Neurology
- Copyright page
- Dedication
- Contents
- Diseases Discussed in the Book
- Preface
- Acknowledgements
- Abbreviations
- Part 1 Missing the Diagnosis Altogether
- Part 2 Misidentifying the Impaired Cognitive Domain
- Part 3 Missing Important Clues in the History
- Part 4 Failure of Pattern Recognition
- Part 5 Difficult-to-Characterize Cognitive/Behavioral Disorders
- Part 6 Clinical Findings That Are Subtle
- Part 7 Misinterpreting Test Results
- Case 31 Does a Positive Amyloid Scan Always Mean Alzheimer Disease?
- Case 32 Herpes Encephalitis Recurrence?
- Case 33 Refractory “VGKC Encephalopathy”
- Case 34 sCJD with Negative 14–3–3?
- Case 35 You Have Been Diagnosed with Alzheimer Disease; Is That It?
- Part 8 Attributing Findings to a Known or Suspected Disorder
- Part 9 Missing Radiographic Clues
- Part 10 Management Misadventures
- Index
- Plate Section (PDF Only)
- References
Case 34 - sCJD with Negative 14–3–3?
from Part 7 - Misinterpreting Test Results
Published online by Cambridge University Press: 03 November 2020
Book contents
- Common Pitfalls in Cognitive and Behavioral Neurology
- Common Pitfalls in Cognitive and Behavioral Neurology
- Copyright page
- Dedication
- Contents
- Diseases Discussed in the Book
- Preface
- Acknowledgements
- Abbreviations
- Part 1 Missing the Diagnosis Altogether
- Part 2 Misidentifying the Impaired Cognitive Domain
- Part 3 Missing Important Clues in the History
- Part 4 Failure of Pattern Recognition
- Part 5 Difficult-to-Characterize Cognitive/Behavioral Disorders
- Part 6 Clinical Findings That Are Subtle
- Part 7 Misinterpreting Test Results
- Case 31 Does a Positive Amyloid Scan Always Mean Alzheimer Disease?
- Case 32 Herpes Encephalitis Recurrence?
- Case 33 Refractory “VGKC Encephalopathy”
- Case 34 sCJD with Negative 14–3–3?
- Case 35 You Have Been Diagnosed with Alzheimer Disease; Is That It?
- Part 8 Attributing Findings to a Known or Suspected Disorder
- Part 9 Missing Radiographic Clues
- Part 10 Management Misadventures
- Index
- Plate Section (PDF Only)
- References
Summary
This 79-year-old left-handed woman presented after six months of progressive cognitive and behavioral changes. She rapidly became forgetful and easily confused, irritable, and had delusional thinking of people trying to harm her emerging over two weeks. Within three months, her language declined to the point where she couldn’t follow commands or produce intelligible or coherent speech. Her balance and walking declined, rendering her wheelchair bound. Her prior medication regimen consisted of amlodipine and atorvastatin, with no changes in recent years.
- Type
- Chapter
- Information
- Common Pitfalls in Cognitive and Behavioral NeurologyA Case-Based Approach, pp. 107 - 109Publisher: Cambridge University PressPrint publication year: 2020
References
Geschwind, M. D. et al. 2003. Challenging the clinical utility of the 14–3–3 protein for the diagnosis of sporadic Creutzfeldt–Jakob disease. Arch Neurol 60(6) 813–816.CrossRefGoogle ScholarPubMed
McGuire, L. I. et al. 2012. RT-QuIC analysis of cerebrospinal fluid in sporadic Creutzfeldt–Jakob disease. Ann Neurol 72(2) 278–285.CrossRefGoogle ScholarPubMed
Meissner, B. et al. 2009. MRI lesion profiles in sporadic Creutzfeldt–Jakob disease. Neurology 72(23) 1994–2001.CrossRefGoogle ScholarPubMed
Steinhoff, B. J. et al. 1996. Accuracy and reliability of periodic sharp wave complexes in Creutzfeldt–Jakob disease. Arch Neurol 53(2) 162–166.Google Scholar
Tschampa, H. J. et al. 2007. Pattern of cortical changes in sporadic Creutzfeldt–Jakob disease. AJNR Am J Neuroradiol 28(6) 1114–1118.Google Scholar
Vitali, P. et al. 2011. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology 76(20) 1711–1719.CrossRefGoogle ScholarPubMed
Zeidler, M. and Green, A. 2004. Advances in diagnosing Creutzfeldt–Jakob disease with MRI and CSF 14–3–3 protein analysis. Neurology 63(3) 410–411.CrossRefGoogle ScholarPubMed
Zerr, I. et al. 1996. Diagnosis of Creutzfeldt–Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. The Lancet 348(9031) 846–849.CrossRefGoogle ScholarPubMed