Book contents
- Frontmatter
- Contents
- Editor, Associate Editors, Artistic Consultant, and Contributors
- Preface
- PART I CONTEXT
- 1 The Endothelium in History
- 2 Introductory Essay: Evolution, Comparative Biology, and Development
- 3 Evolution of Cardiovascular Systems and Their Endothelial Linings
- 4 The Evolution and Comparative Biology of Vascular Development and the Endothelium
- 5 Fish Endothelium
- 6 Hagfish: A Model for Early Endothelium
- 7 The Unusual Cardiovascular System of the Hemoglobinless Antarctic Icefish
- 8 The Fish Endocardium: A Review on the Teleost Heart
- 9 Skin Breathing in Amphibians
- 10 Avian Endothelium
- 11 Spontaneous Cardiovascular and Endothelial Disorders in Dogs and Cats
- 12 Giraffe Cardiovascular Adaptations to Gravity
- 13 Energy Turnover and Oxygen Transport in the Smallest Mammal: The Etruscan Shrew
- 14 Molecular Phylogeny
- 15 Darwinian Medicine: What Evolutionary Medicine Offers to Endothelium Researchers
- 16 The Ancestral Biomedical Environment
- 17 Putting Up Resistance: Maternal–Fetal Conflict over the Control of Uteroplacental Blood Flow
- 18 Xenopus as a Model to Study Endothelial Development and Modulation
- 19 Vascular Development in Zebrafish
- 20 Endothelial Cell Differentiation and Vascular Development in Mammals
- 21 Fate Mapping
- 22 Pancreas and Liver: Mutual Signaling during Vascularized Tissue Formation
- 23 Pulmonary Vascular Development
- 24 Shall I Compare the Endothelium to a Summer's Day: The Role of Metaphor in Communicating Science
- 25 The Membrane Metaphor: Urban Design and the Endothelium
- 26 Computer Metaphors for the Endothelium
- PART II ENDOTHELIAL CELL AS INPUT-OUTPUT DEVICE
- PART III VASCULAR BED/ORGAN STRUCTURE AND FUNCTION IN HEALTH AND DISEASE
- PART IV DIAGNOSIS AND TREATMENT
- PART V CHALLENGES AND OPPORTUNITIES
- Index
- Plate section
22 - Pancreas and Liver: Mutual Signaling during Vascularized Tissue Formation
from PART I - CONTEXT
Published online by Cambridge University Press: 04 May 2010
- Frontmatter
- Contents
- Editor, Associate Editors, Artistic Consultant, and Contributors
- Preface
- PART I CONTEXT
- 1 The Endothelium in History
- 2 Introductory Essay: Evolution, Comparative Biology, and Development
- 3 Evolution of Cardiovascular Systems and Their Endothelial Linings
- 4 The Evolution and Comparative Biology of Vascular Development and the Endothelium
- 5 Fish Endothelium
- 6 Hagfish: A Model for Early Endothelium
- 7 The Unusual Cardiovascular System of the Hemoglobinless Antarctic Icefish
- 8 The Fish Endocardium: A Review on the Teleost Heart
- 9 Skin Breathing in Amphibians
- 10 Avian Endothelium
- 11 Spontaneous Cardiovascular and Endothelial Disorders in Dogs and Cats
- 12 Giraffe Cardiovascular Adaptations to Gravity
- 13 Energy Turnover and Oxygen Transport in the Smallest Mammal: The Etruscan Shrew
- 14 Molecular Phylogeny
- 15 Darwinian Medicine: What Evolutionary Medicine Offers to Endothelium Researchers
- 16 The Ancestral Biomedical Environment
- 17 Putting Up Resistance: Maternal–Fetal Conflict over the Control of Uteroplacental Blood Flow
- 18 Xenopus as a Model to Study Endothelial Development and Modulation
- 19 Vascular Development in Zebrafish
- 20 Endothelial Cell Differentiation and Vascular Development in Mammals
- 21 Fate Mapping
- 22 Pancreas and Liver: Mutual Signaling during Vascularized Tissue Formation
- 23 Pulmonary Vascular Development
- 24 Shall I Compare the Endothelium to a Summer's Day: The Role of Metaphor in Communicating Science
- 25 The Membrane Metaphor: Urban Design and the Endothelium
- 26 Computer Metaphors for the Endothelium
- PART II ENDOTHELIAL CELL AS INPUT-OUTPUT DEVICE
- PART III VASCULAR BED/ORGAN STRUCTURE AND FUNCTION IN HEALTH AND DISEASE
- PART IV DIAGNOSIS AND TREATMENT
- PART V CHALLENGES AND OPPORTUNITIES
- Index
- Plate section
Summary
The cardiovascular system is the first functional organ system to develop in the mammalian embryo. Early during development, it consists mainly of vascular endothelial cells (ECs), which form tubes connected with the heart. Later in development, these vascular tubes develop and branch into a more complex tubular system with a variety of tissue-specific properties. Some of these vascular properties develop when ECs receive signals such as growth factors from surrounding nonvascular tissue cells.
Because blood vessels are present in theembryoat the onset of organogenesis, it is reasonable to expect that they shape the development of organ tissues. Indeed, the pancreas and liver consist of tissues whose features are shaped by signals derived from vascular ECs.
The fact that tissue cells are modulated by signals from ECs and that, in turn, EC phenotypes are influenced by tissue derived signals, suggests that the development of vascularized tissues is critically dependent on mutual signaling. This mutual signaling results in structural and functional coupling between tissues and their respective vascular beds.
THE PRINCIPLE OF MUTUAL SIGNALING
The dorsal aorta is the first intraembryonic artery to form in vertebrates. Despite some differences between vertebrate species, the aorta normally develops through migration of angioblasts from the lateral plate mesoderm towards the midline of the embryo and subsequent formation of a vascular tube connected with the heart. The venous blood vessels, such as the cardinal veins, develop at around the same time and, together with heart and aorta, form the first circulatory system within the embryo. In mammals, additional blood vessels are present, such as those needed to connect embryonic and maternal circulations.
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- Information
- Endothelial Biomedicine , pp. 173 - 180Publisher: Cambridge University PressPrint publication year: 2007