Book contents
- Frontmatter
- Contents
- List of figures
- List of tables
- List of contributors
- Foreword
- Acknowledgments
- 1 Introduction
- 2 Culture and psychopathology
- 3 Culture and ethnicity in psychopharmacotherapy
- 4 Ethnic differences in psychotropic drug response and pharmacokinetics
- 5 Pharmacogenetics of ethnic populations
- 6 Variation in psychotropic responses in the Chinese population
- 7 Variation in psychotropic responses in the Hispanic population
- 8 Identifying inter-ethnic variations in psychotropic response in African Americans and other ethnic minorities
- 9 Complementary medicines in mental disorders
- 10 Cultural factors and the use of psychotropic medications
- 11 Outpatient prescribing practices in Asian countries
- 12 Psychiatric inpatient psychotropic prescribing in East Asia
- 13 Pharmaco-economic implications for Asia and other economically disadvantaged countries
- 14 Integrating theory, practice and economics in psychopharmacology
- 15 Research directions in ethno-psychopharmacology
- Index
- References
7 - Variation in psychotropic responses in the Hispanic population
Published online by Cambridge University Press: 22 August 2009
- Frontmatter
- Contents
- List of figures
- List of tables
- List of contributors
- Foreword
- Acknowledgments
- 1 Introduction
- 2 Culture and psychopathology
- 3 Culture and ethnicity in psychopharmacotherapy
- 4 Ethnic differences in psychotropic drug response and pharmacokinetics
- 5 Pharmacogenetics of ethnic populations
- 6 Variation in psychotropic responses in the Chinese population
- 7 Variation in psychotropic responses in the Hispanic population
- 8 Identifying inter-ethnic variations in psychotropic response in African Americans and other ethnic minorities
- 9 Complementary medicines in mental disorders
- 10 Cultural factors and the use of psychotropic medications
- 11 Outpatient prescribing practices in Asian countries
- 12 Psychiatric inpatient psychotropic prescribing in East Asia
- 13 Pharmaco-economic implications for Asia and other economically disadvantaged countries
- 14 Integrating theory, practice and economics in psychopharmacology
- 15 Research directions in ethno-psychopharmacology
- Index
- References
Summary
Introduction
According to the United States Census Bureau (2005), 41.3 million Hispanics reside in the United States and constitute the largest ethnic minority group in the country. Our knowledge base, as it pertains to the nature of the psychopharmacolo- gical responsiveness manifested by Hispanics, continues to lag. While the number of psychopharmacological studies including Hispanic patients has increased, they continue to be plagued by the same methodological problems that have been noted in previous reviews (Mendoza & Smith, 2000) and the data is, therefore, difficult to interpret with confidence. To date, the only substantive pharmacogenetic data that has been generated has been in Mexican Americans (a.k.a. Hispanic-Whites), and Hispanics with a Black racial affiliation remain largely ignored. In the following, we review the extant clinical research investigations that have been conducted utilizing Hispanic subjects that have received antidepressant and antipsychotic medications. Pharmacogenetic findings in the Mexican American subgroup are briefly summar- ized, as is the data regarding drug–diet and drug–herbal interactions. Concluding remarks include a discussion of the limitations and methodological problems associated with this body of research.
Antidepressants
Tricyclics
Early landmark studies utilizing Hispanic subjects in the 1980s (Escobar & Tuason, 1980; Marcos & Cancro, 1982) compared the efficacy and response of several tricyclic antidepressants to placebo. They were the first to hint at a possible heightened placebo response in Hispanics and they suggested that certain Hispanic subjects may experience greater side effects at standardized dosages.
- Type
- Chapter
- Information
- Ethno-psychopharmacologyAdvances in Current Practice, pp. 97 - 110Publisher: Cambridge University PressPrint publication year: 2008
References
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