Chance is no threat to the notion of design as is evident from the fact that we actually use it to achieve our own purposes. Some of these uses are long established but the ready availability of massive computing power has opened the way for a much wider range of applications. We are now able to generate randomness on a large enough scale to simulate many complex processes. Applications range from chemistry to music, with statistical sampling still playing a central role. Competitive situations call for chance selections in the choice of strategies, and so-called genetic algorithms attempt to mimic design by random variation and natural selection. These and other uses of chance are surveyed in this chapter.