Ensconced in Maimonides' Commentary of the Mishnah Tractate Sanhedrin between comments concerning the fundamental tenets of the Jewish faith and his well-known thirteen fundamental principles is a brief section on the days of the messiah. Somewhat surprisingly, Maimonides (AD 1135–1204) cites Isa. 42.4a to validate the proposition that following an extended reign the messiah will die. A translation reads as follows:

Maimonides' usage provides but one, albeit late, example of Jewish messianic exegesis of Isa. 42.1–4. That he would appeal to this text in support of his understanding of the days of the messiah is not unexpected given its long history of usage within Jewish messianic thought. What is rather unusual, however, is that he would cite Isa. 42.4a to validate the messiah's death.

Engaging in a messianic exegesis of his own nearly a millennium before, the author of the Gospel of Matthew also cites Isa. 42.1–4; however, in Matthew's version of the text in 12.18–21, the reference to weakness and perhaps even death found in Isa. 42.4a is absent. This line of text has been excised from Matthew's version of Isa. 42.4a (Matt. 12.20b) and an unknown piece of text inserted in its place (see the passages below).