Book contents
- Frontmatter
- Contents
- Contributors
- Figures and Tables
- Preface
- Introduction
- Chapter 1 Single-Molecule FRET: Technique and Applications to the Studies of Molecular Machines
- Chapter 2 Visualization of Molecular Machines by Cryo-Electron Microscopy
- Chapter 3 Statistical Mechanical Treatment of Molecular Machines
- Chapter 4 Exploring the Functional Landscape of Biomolecular Machines via Elastic Network Normal Mode Analysis
- Chapter 5 Structure, Function, and Evolution of Archaeo-Eukaryotic RNA Polymerases – Gatekeepers of the Genome
- Chapter 6 Single-Molecule Fluorescence Resonance Energy Transfer Investigations of Ribosome-Catalyzed Protein Synthesis
- Chapter 7 Structure and Dynamics of the Ribosome as Revealed by Cryo-Electron Microscopy
- Chapter 8 Viewing the Mechanisms of Translation through the Computational Microscope
- Chapter 9 The Ribosome as a Brownian Ratchet Machine
- Chapter 10 The GroEL/GroES Chaperonin Machine
- Chapter 11 ATP Synthase – A Paradigmatic Molecular Machine
- Chapter 12 ATP-Dependent Proteases: The Cell's Degradation Machines
- Index
Preface
Published online by Cambridge University Press: 05 January 2012
- Frontmatter
- Contents
- Contributors
- Figures and Tables
- Preface
- Introduction
- Chapter 1 Single-Molecule FRET: Technique and Applications to the Studies of Molecular Machines
- Chapter 2 Visualization of Molecular Machines by Cryo-Electron Microscopy
- Chapter 3 Statistical Mechanical Treatment of Molecular Machines
- Chapter 4 Exploring the Functional Landscape of Biomolecular Machines via Elastic Network Normal Mode Analysis
- Chapter 5 Structure, Function, and Evolution of Archaeo-Eukaryotic RNA Polymerases – Gatekeepers of the Genome
- Chapter 6 Single-Molecule Fluorescence Resonance Energy Transfer Investigations of Ribosome-Catalyzed Protein Synthesis
- Chapter 7 Structure and Dynamics of the Ribosome as Revealed by Cryo-Electron Microscopy
- Chapter 8 Viewing the Mechanisms of Translation through the Computational Microscope
- Chapter 9 The Ribosome as a Brownian Ratchet Machine
- Chapter 10 The GroEL/GroES Chaperonin Machine
- Chapter 11 ATP Synthase – A Paradigmatic Molecular Machine
- Chapter 12 ATP-Dependent Proteases: The Cell's Degradation Machines
- Index
Summary
Preface
The concept of this book goes back to the Center for Molecular Machines, which I started together with similarly minded colleagues – Nilesh Banavali, April Burch, Steve Hanes, Joachim Jaeger, and Janice Pata, among others – at the Wadsworth Center in Albany back in 2005. The most visible manifestation of the Center for Molecular Machines was a monthly seminar series, which we called Molecular Machine Shop. The idea was to highlight some of the complicated structures at work in the cell, which were coming increasingly into view mainly through the efforts of X-ray crystallography and cryo-electron microscopy, and to bring out common features and general principles underlying these biological nanomachines. The seminars were meant to encourage interdisciplinary discourse as it was becoming increasingly clear that no single technique alone could unravel the mystery of how such machines work.
In June 2007, we organized a one-day minisymposium in Albany, which brought together experts studying molecular machines with the tools of X-ray crystallography, cryo-EM, single-molecule FRET, and molecular dynamics. In the wake of the event, Allan Ross, then senior editor at Cambridge University Press, approached me to ask if I would be interested in editing a volume on the theme. Some of the speakers of the minisymposium were receptive to the idea, and by asking other scholars working in the field I was lucky in the end to be able to assemble a team of the highest caliber.
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- Information
- Molecular Machines in BiologyWorkshop of the Cell, pp. xiii - xivPublisher: Cambridge University PressPrint publication year: 2011
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