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23 - High-risk studies, brain development, and schizophrenia

Published online by Cambridge University Press:  04 August 2010

By
Matcheri S. Keshavan
Edited by
Matcheri S. Keshavan ,
James L. Kennedy  and
Robin M. Murray
Matcheri S. Keshavan
Affiliation:
University of Pittsburgh School of Medicine, Pittsburgh and Wayne State University School of Medicine, Detroit, USA
Matcheri S. Keshavan
Affiliation:
University of Pittsburgh
James L. Kennedy
Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray
Affiliation:
Institute of Psychiatry, London
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Summary

This chapter reviews the several approaches to investigate premorbid risk for schizophrenia. It presents a critical appraisal of the existing studies focusing on the populations at risk for schizophrenia, the issues surrounding study design, predictive and outcome factors identified so far, and the timing of the studies. Studies of premorbid risk, risk for schizophrenia and prospective studies have utilized genetic propensity, neurobehavioral markers, or psychopathology to identify the risk status. The chapter outlines the potential merits and disadvantages of these strategies, reviews the lessons learned from the early first high-risk (HR) studies and presents a rationale for more focused next-generation studies to examine premorbid risk. Recent advances in developmental neurobiology and neuroscience make it reasonable to expect a paradigm shift in research on schizophrenia. It is hoped that the third millennium will usher in a new generation of research studies on high-risk (HR) populations.

Keywords

brain developmentclinical high-risk strategiescognitive deficitsgenetic high-risk studieshigh-risk studiesgeneral population cohort studiesfollow-back and retrospective studiesenhanced high-risk strategiesneurobehavioral high-risk strategiesschizophrenia
Type
Chapter
Information
Neurodevelopment and Schizophrenia , pp. 432 - 454
Publisher: Cambridge University Press
Print publication year: 2004

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