Book contents
- Frontmatter
- Contents
- List of contributors
- Foreword
- Preface
- Part I Basic aspects
- Part II Etiological factors
- 6 Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoid involvement in major psychiatric disorders
- 7 Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia
- 8 Can structural magnetic resonance imaging provide an alternative phenotype for genetic studies of schizophrenia?
- 9 Nutritional factors and schizophrenia
- 10 Schizophrenia, neurodevelopment, and epigenetics
- 11 Early environmental risk factors for schizophrenia
- 12 Transcriptomes in schizophrenia: assessing altered gene expression with microarrays
- 13 Is there a role for social factors in a comprehensive development model for schizophrenia?
- 14 How does drug abuse interact with familial and developmental factors in the etiology of schizophrenia?
- Part III Pathophysiology
- Part IV Clinical implications
- Index
- Plate section
- References
10 - Schizophrenia, neurodevelopment, and epigenetics
Published online by Cambridge University Press: 04 August 2010
Book contents
- Frontmatter
- Contents
- List of contributors
- Foreword
- Preface
- Part I Basic aspects
- Part II Etiological factors
- 6 Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoid involvement in major psychiatric disorders
- 7 Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia
- 8 Can structural magnetic resonance imaging provide an alternative phenotype for genetic studies of schizophrenia?
- 9 Nutritional factors and schizophrenia
- 10 Schizophrenia, neurodevelopment, and epigenetics
- 11 Early environmental risk factors for schizophrenia
- 12 Transcriptomes in schizophrenia: assessing altered gene expression with microarrays
- 13 Is there a role for social factors in a comprehensive development model for schizophrenia?
- 14 How does drug abuse interact with familial and developmental factors in the etiology of schizophrenia?
- Part III Pathophysiology
- Part IV Clinical implications
- Index
- Plate section
- References
Summary
The neurodevelopmental theory of schizophrenia is based on the hypothesis that early brain insults affect brain development and eventually cause dysfunction of the mature brain, predisposing to schizophrenia. A large group of putative etiological factors has been suggested, investigated, and categorized into environmental and genetic groups. The first group includes various obstetric complications such as birth trauma, maternal viral infection during pregnancy, pre-eclampsia, and deficiencies in nutrition. The second group provokes emphasis on DNA sequence variation in the genes that may play a role in neurodevelopment. This chapter suggests the idea that developmental changes in schizophrenia can be caused and/or mediated by epigenetic factors. It argues that shifting the emphasis from the traditional gene-environment dichotomy to epigenetics may provide a cohesive theoretical framework for a myriad of fragmented phenomenological and molecular findings in schizophrenia and lead to a series of new molecular strategies, designs, and approaches.
- Type
- Chapter
- Information
- Neurodevelopment and Schizophrenia , pp. 174 - 190Publisher: Cambridge University PressPrint publication year: 2004
References
, (2000). The DNA methyltransferases of mammals. Hum Mol Genet 9: 2395–2402CrossRefGoogle ScholarPubMed
, (2000). Twin studies of schizophrenia: from bow-and-arrow concordances to Star Wars Mx and functional genomics. Am J Med Genet 97: 12–173.0.CO;2-U>CrossRefGoogle ScholarPubMed
, , , , (2002). On the epigenetic regulation of the human reelin promoter. Nucl Acids Res 30: 2930–2939CrossRefGoogle ScholarPubMed
(2002). FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation. Biochem Biophys Res Commun 295: 575–581CrossRefGoogle ScholarPubMed
, , (2001). Profiling methyl-CpG specific determinants on transcriptionally silent chromatin. Mol Biol Rep 28: 209–215CrossRefGoogle ScholarPubMed
Gottesman, I., Shields, J. (1982). Schizophrenia: The Epigenetic Puzzle. Cambridge, UK: Cambridge University Press
, , et al. (2001). Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20: 6969–6978CrossRefGoogle ScholarPubMed
, (1997). Exploring and explaining epigenetic effects. Trends Genet 13: 293–295CrossRefGoogle ScholarPubMed
Holliday, R. (1996). DNA methylation in eukaryotes: 20 years on. In Epigenetic Mechanisms of Gene Regulation, ed. V. Russo, R. Martienssen, A. Riggs. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 5–27
, (1975). DNA modification mechanisms and gene activity during development. Science 187: 226–232CrossRefGoogle ScholarPubMed
Jablonka, E., Lamb, M. (1995). Epigenetic Inheritance and Evolution. Oxford: Oxford University Press
, , et al. (2001). Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 27: 31–39CrossRefGoogle ScholarPubMed
Kolb, B. (1995). Brain Plasticity and Behavior. Mahwah, NJ: Lawrence Erlbaum Associates
Kraepelin, E. (1919). Dementia Praecox and Paraphrenia. Edinburgh: Livingstone
, (2002). Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25: 409–432CrossRefGoogle ScholarPubMed
(2002). Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3: 662–673CrossRefGoogle ScholarPubMed
, , , , (2001). Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 293: 2453–2455CrossRefGoogle ScholarPubMed
(1951). Chromosome organization and genic expression. Genes and Mutations. Cold Spring Harb Symp Quant Biol XVI: 13–47CrossRefGoogle Scholar
, , et al. (1998). Sex-specific exons control DNA methyltransferase in mammalian germ cells. Development 125: 889–897Google ScholarPubMed
Morgan, T. H. (1934). Embryology and Genetics. New York: Columbia University Press
(2000). The genes for major psychosis: aberrant sequence or regulation?Neuropsychopharmacology 23: 1–12CrossRefGoogle ScholarPubMed
(2001). Human morbid genetics revisited: relevance of epigenetics. Trends Genet 17: 142–146CrossRefGoogle ScholarPubMed
, , , (2002). Major psychosis and chromosome 22: genetics meets epigenetics. CNS Spectrums 7: 209–214CrossRefGoogle ScholarPubMed
, , et al. (2003). Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?Schizophr Bull 29: 169–178CrossRefGoogle ScholarPubMed
, , et al. (2001). Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276: 36734–36741CrossRefGoogle ScholarPubMed
, , , , (2002). Metastable epialleles in mammals. Trends Genet 18: 348–351CrossRefGoogle ScholarPubMed
, (1999). Epigenetic control of gene expression. Results Probl Cell Differ 25: 189–204CrossRefGoogle ScholarPubMed
, , (2001). Epigenetic reprogramming in mammalian development. Science 293: 1089–1093CrossRefGoogle ScholarPubMed
, , (2001). Nuclear cloning and epigenetic reprogramming of the genome. Science 293: 1093–1098CrossRefGoogle Scholar
Riggs, A., Xiong, Z., Wang, L., LeBon, J. M. (1998). Methylation dynamics, epigenetic fidelity and X chromosome structure. In Epigenetics, Vol. Novartis Foundation Symposium 214: Epigenetics, ed. A. Wolffe. Chichester, UK: Wiley, pp. 214–227
(1975). X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet 14: 9–25CrossRefGoogle ScholarPubMed
(2001). Mechanisms and brain specific consequences of genomic imprinting in Prader–Willi and Angelman syndromes. Gene Funct Dis 1: 7–253.0.CO;2-N>CrossRefGoogle Scholar
(1997). Psychopathology in women and men: focus on female hormones. Am J Psychiatry 154: 1641–1647CrossRefGoogle ScholarPubMed
, , et al. (1999). DNA methylation represses transcription in vivo. Nat Genet 22: 203–206CrossRefGoogle ScholarPubMed
(2002). Conrad Hal Waddington: the last Renaissance biologist?Nat Rev Genet 3: 889–895CrossRefGoogle ScholarPubMed
, (2000). Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos. Genes Dev 14: 313–327Google ScholarPubMed
Torrey, E. F., Bowler, A. E., Taylor, E. H., Gottesman, I. I. (1999). Schizophrenia and Manic Depressive Disorder. The Biological Roots of Mental Illness as Revealed by the Landmark Study of Identical Twins. New York: Basic Books
, , et al. (2002). An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA 99: 17095–17100CrossRefGoogle ScholarPubMed
, (2001). Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev 23(Suppl. 1): S147–S151CrossRefGoogle ScholarPubMed
, (1999). Cytosine methylation and mammalian development. Genes Dev 13: 26–34CrossRefGoogle ScholarPubMed
, (1999). DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation. Mol Cell Biol 19: 164–172CrossRefGoogle ScholarPubMed
Wolffe, A. P., Barton, M. C. (2000). Developmental regulation of chromatin function and gene expression. In Chromatin Structure and Regulation, ed. S. C. R. Elgin, J. L. Workman. Oxford: Oxford University Press, pp. 182–202
, (1999). Epigenetics: regulation through repression. Science 286: 481–486CrossRefGoogle ScholarPubMed
(1998). Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry 155: 1661–1670CrossRefGoogle Scholar
(1997). Does the genotype for schizophrenia often remain unexpressed because of canalization and stochastic events during development?Psychol Med 27: 659–668CrossRefGoogle ScholarPubMed
Yeivin, A., Razin, A. (1993). Gene methylation patterns and expression. In DNA Methylation: Molecular Biology and Biological Significance, ed. J. Jost, H. Saluz. Basel: Birkhauser Verlag, pp. 523–568CrossRef
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