Book contents
- Frontmatter
- Contents
- List of Contributors
- Preface
- NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
- Part One Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
- 1 Principles of Neurobehavioral Teratology
- 2 The Neurodevelopmental Consequences of Very Preterm Birth: Brain Plasticity and Its Limits
- 3 Neurodevelopment During Adolescence
- 5 Prenatal Risk Factors for Schizophrenia
- 5 Obstetric Complications and Neurodevelopmental Mechanisms in Schizophrenia
- 6 Maternal Influences on Prenatal Neural Development Contributing to Schizophrenia
- Part Two Animal Models of Neurodevelopment and Psychopathology
- Part Three Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
- Part Four The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
- Index
- References
5 - Obstetric Complications and Neurodevelopmental Mechanisms in Schizophrenia
Published online by Cambridge University Press: 10 August 2009
- Frontmatter
- Contents
- List of Contributors
- Preface
- NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
- Part One Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
- 1 Principles of Neurobehavioral Teratology
- 2 The Neurodevelopmental Consequences of Very Preterm Birth: Brain Plasticity and Its Limits
- 3 Neurodevelopment During Adolescence
- 5 Prenatal Risk Factors for Schizophrenia
- 5 Obstetric Complications and Neurodevelopmental Mechanisms in Schizophrenia
- 6 Maternal Influences on Prenatal Neural Development Contributing to Schizophrenia
- Part Two Animal Models of Neurodevelopment and Psychopathology
- Part Three Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
- Part Four The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
- Index
- References
Summary
Obstetric complications (OCs) are robust environmental correlates of schizophrenia (McNeil, 1988; Cannon, 1997). Deviations from the normal course of pregnancy, delivery, or early neonatal life have been associated with the development of schizophrenia in numerous studies with many different types of samples, including: adult schizophrenics and matched comparison subjects (O'Callaghan et al., 1992; Kendell, Juszczak, & Cole, 1996; Hultman, Ohman, Cnattingius, Wieselgren, & Lindstrom, 1997), siblings and twins discordant for schizophrenia (Lane & Albee, 1966; Pollack, Woerner, Goodman, & Greenberg, 1966; Pollin & Stabenau, 1968; Woerner, Pollack, & Klein, 1971; Markow & Gottesman, 1989; Eagles et al., 1990; Bracha, Torrey, Gottesman, Bigelow, & Cunniff, 1992; Günther-Genta, Bovet, & Hohlfeld, 1994; Kinney et al., 1994; Torrey et al., 1994), adopted schizophrenics (Jacobsen & Kinney, 1980), offspring of schizophrenic parents (Parnas et al., 1982; Fish, Marcus, Hans, Auerbach, & Perdue, 1992), and representative birth cohorts (Buka, Tsuang, & Lipsitt, 1993; Dalman, Allebeck, Cullberg, Grunewald, & Koster, 1999; Zornberg, Buka, & Tsuang, 2000). The two studies reporting null results are not outliers in this respect, only in that the 95 percent confidence intervals of their risk estimates included values of one (Done et al., 1991; Buka et al., 1993). One of these studies found that odds of schizophrenia were 2.6 times higher among individuals with a history of fetal hypoxia than among those without such a history (p = .13), but statistical power was limited by a small number of schizophrenia outcomes (N = 8; Buka et al., 1993).
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- Information
- Neurodevelopmental Mechanisms in Psychopathology , pp. 111 - 137Publisher: Cambridge University PressPrint publication year: 2003
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