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Chapter 7 - Neural tumors

Published online by Cambridge University Press:  05 July 2016

Ophelia E. Dadzie
Affiliation:
Hillingdon Hospitals NHS Foundation Trust
Meera Mahalingam
Affiliation:
VA Consolidated Laboratories, New England
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Publisher: Cambridge University Press
Print publication year: 2000

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References

Primary Sources

Canelas, M.M., Reis, J.P., Cordeiro, M., et al. (2010). Lipomatous neurofibroma associated with segmental neurofibromatosis. J Cutan Pathol, 37, 705–6.Google Scholar
Vecchio, G.M., Amico, P., Leone, G., et al. (2010). Lipoblast-like signet-ring cells in neurofibroma: a potential diagnostic pitfall of malignancy. Pathologica, 102, 108.Google Scholar
Kazakov, D.V., Vanecek, T., Sima, R., et al. (2005). Dendritic cell neurofibroma with pseudorosettes lacks mutations in exons 1–15 of the neurofibromatosis type 2 gene. Am J Dermatopathol, 27, 286–9.Google Scholar
Taungjaruwinai, W.M. and Goldberg, L.J. (2009). Multinucleate giant cells in neurofibromas: a clue to the diagnosis of neurofibromatosis. J Cutan Pathol, 36, 1164–7.Google Scholar
Lerman, M.A., Li, C.C., and Woo, S.B. (2014). Dendritic cell neurofibroma with pseudorosettes: a clinicopathologic and immunohistochemical study of 5 intraoral cases. Oral Surg Oral Med Oral Pathol Oral Radiol, 117, 221–6.Google Scholar
Schaffer, J.V., Chang, M.W., Kovich, O.l., et al. (2007). Pigmented plexiform neurofibroma: distinction from a large congenital melanocytic nevus. JAAD, 56, 862–8.Google Scholar
Fetsch, J.F., Michal, M., and Miettien, M. (2000). Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients. Am J Surg Pathol, 24, 331–43.Google Scholar
Honda, M., Arai, E., Sawada, S., et al. (1995). Neurofibromatosis 2 and neurilemmomatosis genes are identical. J Invest Dermatol, 104, 74–7.Google Scholar
Friedman, J.M. (1999). Epidemiology of neurofibromatosis type 1. Am J Med Genet, 89, 16.Google Scholar
Pongpudpunth, M., Bhawan, J., Al-Natour, S.H., et al. (2010). Nestin positive stem cells in neurofibromas from patients with neurofibromatosis type 1 – tumorigenic or incidental? Am J Dermatopathol, 32, 574–7.Google Scholar
Schaffer, J.V., Chang, M.W., Kovich, O.I., et al. (2007). Pigmented plexiform neurofibroma: distinction from a large congenital melanocytic nevus. JAAD, 56, 862–8.Google Scholar
Motoi, T., Ishida, T., Kawato, A., et al. (2005). Pigmented neurofibroma: review of Japanese patients with an analysis of melanogenesis demonstrating coexpression of c-met protooncogene and microphthalmia-associated transcription factor. Hum Pathol, 36, 871–7.Google Scholar
Kuhnen, C., Herter, P., Soimaru, C., et al. (2002). Pigmented (melanotic) neurofibroma. Report of an unusual case with immunohistochemical, ultrastructural and cytogenetic analyses. Pathol Res Pract, 198, 125–31.Google Scholar
Anderson, B. and Robertson, D.M. (1979). Melanin containing neurofibroma: case report with evidence of Schwann cell origin of melanin. Can J Neurol Sci, 6, 139–43.Google Scholar
Zheng, H., Chang, L., Patel, N., et al. (2008). Induction of abnormal proliferation by nonmyelinating Schwann cells triggers neurofibroma formation. Cancer Cell, 13, 117–28.Google Scholar
Xu, G.F., O'Connell, P., Viskochil, D., et al. (1990). The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell, 62, 599608.Google Scholar

Secondary Sources

Megahed, M. (1994). Plexiform schwannoma. Am J Dermatopathol, 16, 288–93.Google Scholar
Argeny, i A.B., Balogh, K., and Abraham, A.A. (1993). Degenerative (“ancient”) changes in benign cutaneous schwannoma. A light microscopic, histochemical and immunohistochemical study. J Cut Pathol, 20, 148–53.Google Scholar
Chan, J.K.C. and Fok, K.O. (1996). Pseudoglandular schwannoma. Histopathology, 29, 481–4.Google Scholar
Lewis, Z.T., Geisinger, K.R., Pichardo, R., et al. (2005). Schwannoma with neuroblastoma-like rosettes: An unusual morphologic variant. Am J Dermatopathol, 27, 243–6.Google Scholar
Lee, Y. S., Kim, J.O., and Park, S.E. (2014). Ancient schwannoma of the thigh mimicking a malignant tumor: a report of two cases, with emphasis on MRI findings. Br J Radiol, 83, e154e157.Google Scholar
Kindblom, L.G., Meis-Kindblom, J.M., Havel, G., et al. (1998). Benign epithelioid schwannoma. Am J Surg Pathol, 22, 762–70.Google Scholar
Berg, J.C., Scheithauer, B.W., Spinner, R.J., et al. (2008). Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region. Hum Pathol, 39, 633–40.Google Scholar
Deng, A., Petrali, J., Jaffe, D., et al. (2005). Benign cutaneous pseudoglandular schwannoma: a case report. Am J Dermatopathol, 27, 432–5.Google Scholar
Biswas, A., Setia, N., and Bhawan, J. (2011). Cutaneous neoplasms with prominent Verocay body-like structures: The so-called “rippled pattern”. Am J Dermatopath, 33, 539–50.Google Scholar
Cieslak, A.K. and Stout, A.P. (1946). Traumatic hand amputation neuromas. Arch Surg, 53, 646–51.Google Scholar
Gorlin, R.J., Sedana, H.O., Vickers, R.A., et al. (1968). Multiple mucosal neuromas, pheochromocytoma and medullary carcinoma of the thyroid – a syndrome. Cancer, 22, 293–9.Google Scholar
Reed, R.J., Fine, R.M., and Meltzer, H.D. (1972). Palisaded, encapsulated neuroma of the skin. Arch Dermatol, 106, 865.Google Scholar
Hare, P.J. (1954). Rudimentary polydactyly. Br J Dermatol, 66, 402–8.Google Scholar
Walker, D.M. (1973). Oral mucosa neuroma-medullary thyroid carcinoma syndrome. Br J Dermatol, 88, 599603.Google Scholar
Pujol, R.M, Matius-Guiu, X., Miralles, J., et al. (1997). Multiple idiopathic mucosal neuromas: A minor form of MEN2B or a new entity? JAAD, 37, 349–52.Google Scholar
Harkin, J.C. and Reed, J.J. (1969). Tumors of the Peripheral Nervous System. Washington, DC: Armed Forces Institute of Pathology, 60–4.Google Scholar
Gallagher, R.L. and Helwig, E.B. (1980). Neurothekeoma–a benign cutaneous tumor of neural origin. Am J Clin Pathol, 74, 759–61.Google Scholar
Fetsch, J.F., Laskin, W.B., and Miettinen, M. (2005). Nerve sheath myxoma: a clinicopathologic and immunohistochemical analysis of 57 morphologically distinctive, S-100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high local recurrence rate. Am J Surg Pathol, 29, 1615–24.Google Scholar
Nishioka, M., Aguirre, R.L., Ishikawa, A., et al. (2009). Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histologic and immunohistochemical features of 3 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 107, e28e33.Google Scholar
Sheth, S., Li, X., Binder, S., et al. (2011). Differential gene expression profiles of neurothekeomas and nerve sheath myxoma by microarray analysis. Mod Pathol, 24, 343–54.Google Scholar
Zamecnik, M. and Sedlacek, T. (2010). Nerve sheath myxoma with bidirectional schwannomatous and perineural differentiation. Ces-slov Patol, 3, 73–6.Google Scholar
Anngervall, L., Kindblom, K.G., and Haglid, K. (1984). Dermal nerve sheath myxoma: a light and electron microscopic, histochemical and immunohistochemical study. Cancer, 53, 1752–9.Google Scholar
Horncick, J.L. and Fletcher, C.D. (2007). Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol, 31, 329–40.Google Scholar
Mahalingam, M., Alter, J.N., and Bhawan, J. (2006). Multiple cellular neurothekeomas – A case report and review on the role of immunohistochemistry as a histologic adjunct. J Cutan Pathol, 33, 51–6.Google Scholar
Zedek, D.C., White, W.L., and McCalmont, T.H. (2009). Desmoplastic cellular neurothekeoma: Clinicopathologic analysis of 12 cases. J Cut Pathol, 36, 1185–90.Google Scholar
Sheth, S., Li, X., Binder, S., et al. (2011). Differential gene expression profiles of neurothekeomas and nerve sheath myxoma by microarray analysis. Mod Pathol, 24, 343–54.Google Scholar
Cardoso, J. and Calonje, E. (2012). Cellular neurothekeoma with perineural extension: a potential diagnostic pitfall. J Cut Pathol, 39, 662–4.Google Scholar
Requena, L., Sitthinamsuwan, P, Fried, I., et al. (2013). A benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma. Test Site, 37, 845–52.Google Scholar
Bhatia, S., Chu, P., and Weinberg, J.M. (2003). Atypical cellular neurothekeoma. Dermatol Surg, 29, 1154–7.Google Scholar
Fullen, D.R., Lowe, L., and Su, L.D. (2003). Antibody to S100A6 protein is a sensitive immunohistochemical marker for neurothekeoma. J Cut Pathol, 30, 118–22Google Scholar
Busam, K.J., Mentzel, T., Colpaert, C., et al. (1998). Atypical or worrisome features in a cellular neurothekeoma: a study of 10 cases. Am J Surg Pathol, 22, 1067–72.Google Scholar
Stratton, J. and Billings, S.D. (2013). Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features. Mod Pathol, 17, 701–10.Google Scholar
Pitchford, C.W., Schwartz, H.S., Atkinson, J.B., et al. (2006). Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol, 30, 1624–9.Google Scholar
Hornick, J.L. and Fletcher, C.D. (2005). Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol, 29, 845–58.Google Scholar
Kazakov, D.V., Pitha, J., Sima, R., et al. (2005). Hybrid peripheral nerve sheath tumors: schwannoma-perineurioma and neurofibroma-perineurioma: a report of three cases in extradigital locations. Ann Diagn Pathol, 9, 1623.Google Scholar
Requena, L., Sitthinamsuwan, P., Fried, I., et al. (2013). A benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma. Am J Surg Pathol, 37, 845–52.Google Scholar
Hornick, J.L., Bundock, E.A., and Fletcher, C.D. (2009). Hybrid schwannoma/perineurioma: Clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol, 33, 1554–61.Google Scholar
Hirose, T., Scheithauer, B.W., and Sano, T. (1998). Perineurial malignant peripheral nerve sheath tumor (MPNST): A clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol, 22, 1368–78.Google Scholar
Zámecník, M. and Michal, M. (1999). Malignant peripheral nerve sheath tumor with perineurial cell differentiation (malignant perineurioma). Pathol Int, 49, 6973.Google Scholar
Karaki, S., Mochida, J., Lee, Y.H., et al. (1999). Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy. Pathol Int, 49, 820–5.Google Scholar
Fukunaga, M. (2001). Unusual malignant perineurioma of soft tissue. Virchows Arch, 439, 212–14.Google Scholar
Rosenberg, A.S., Langee, C.L., Stevens, G.L., et al. (2002). Malignant peripheral nerve sheath tumor with perineurial differentiation: “malignant perineurioma.” J Cutan Pathol, 29, 362–7.Google Scholar
Sato, K., Ueda, Y., Miwa, S., et al. (2008). Low-grade malignant soft-tissue perineurioma: Interphase fluorescence in situ hybridization. Pathol Int, 58, 718–22.Google Scholar
Lazarus, S.S. and Trombetta, L.D. (1978). Ultrastructural identification of a benign perineurial cell tumor. Cancer, 41, 1823–9.Google Scholar
Rubin, A.I., Yassaee, M., Johnson, W., et al. (2009). Multiple cutaneous sclerosing perineuriomas: An extensive presentation with involvement of the bilateral upper extremities. J Cutan Pathol, 36, 60–5.Google Scholar
Rekhi, B. (2013). Perineurial malignant peripheral nerve sheath tumor in the setting of multiple soft tissue perineuriomas: A rare presentation of an uncommon tumor. J Can Res Ther, 9, 131.Google Scholar
Sidwell, R.U., Rousse, P., Owen, R.A., et al. (2008). Granular cell tumor of the scrotum in a child with Noonan syndrome. Pediatr Dermatol, 25, 341–3.Google Scholar
Fanburg-Smith, J.C., Meis-Kindblom, J.M., Fante, R., et at. (1998). Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol, 22, 779–94.Google Scholar
Ramaswamy, P.V., Storm, C.A., Filiano, J.J., et al. (2010). Multiple granular cell tumors in a child with Noonan syndrome. Pediatr Dermatol, 27, 209–11.Google Scholar
Lazar, A.J.F. and Fletcher, C.D.M. (2005). Primitive non-neural granular cell tumor of skin clinicopathologic analysis of 13 cases. Am J Surg Pathol, 29, 927–34.Google Scholar
Yogesh, T.L., and Sowmya, S.V. (2011). Granules in granular cell lesions of the head and neck: A review. International Scholarly Research Notices, http://dx.doi.org/10.5402/2011/215251.Google Scholar
Le, B.H., Boyer, P.J., Lewis, J.E., et al. (2004). Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. Arch Pathol Lab Med, 128, 771–5.Google Scholar
Lack, E.E., Worsham, G.F., Callihan, M.D., et al. (1980). Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol, 13, 301–16.Google Scholar
Khansur, T., Balducci, L., and Tavassoli, M. (1987). Granular cell tumor. Clinical spectrum of the benign and malignant entity. Cancer, 60, 220–2.Google Scholar
Price, M.A., Horwitz, P., Tschen, J.A., et al. (1995). Malignant granular cell tumor. Dermatol Surg, 21, 820–1.Google Scholar
Mahoney, A., Garg, A., Wolpowitz, D., et al. (2010). Atypical granular cell tumor – apropos of a case with indeterminate malignant potential. Am J Dermatopathol, 32, 370–3.Google Scholar
Mahalingam, M., LoPiccolo, D., and Byers, H.R. Expression of PGP 9.5 in granular cell nerve sheath tumors: An immunohistochemical study of six cases. J Cutan Pathol, 2001,28, 2832.Google Scholar
Miedema, J.R. and Zedek, D. (2012). Cutaneous meningioma. Arch Pathol Lab Med, 136, 208–11.Google Scholar
Nochomovitz, L.E., Jannota, F., and Orenstein, J.M. (1985). Meningioma of the scalp. Light and electron microscopic observations. Arch Pathol Lab Med, 109, 92–5.Google Scholar
Tron, V., Bellamy, C., and Wood, W. (1993). Familial cutaneous heterotopic meningeal nodules. J Am Acad Dermatol, 28, 1015–17.Google Scholar
Theaker, J.M., Fletcher, C.D.M., and Tudway, A.J. (1990). Cutaneous heterotopic meningeal nodules. Histopathology, 16, 475–9.Google Scholar
Lopez, D.A., Silvers, D.N., and Helwig, E.B. (1974). Cutaneous meningiomas – a clinicopathologic study. Cancer, 34, 728–44.Google Scholar
Wong, H.H. and Wang, J. (2010). Merkel cell carcinoma. Arch Pathol Lab Med, 134, 1711–16.Google Scholar
Paik, J.Y., Hall, G., Clarkson, A., et al. (2011). Immunohistochemistry for Merkel cell polyomavirus is highly specific but not sensitive for the diagnosis of Merkel cell carcinoma in the Australian population. Hum Pathol, 42, 1385–90.Google Scholar
Calder, K.B., Coplowitz, S., Schlauder, S., et al. (2007). A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. Cutan Pathol, 34, 918–23.Google Scholar
Beer, T.W. (2009). Merkel cell carcinomas with CK20 negative and CK7 positive immunostaining. J Cutan Pathol, 36, 385–6.Google Scholar
Marghalani, S., Feller, K., Mahalingam, M., et al. (2015). Huntingtin interacting protein (HIP1) as a histopathologic adjunct in the diagnosis of Merkel cell carcinoma. Int J Dermatol, 54(6):640–7.Google Scholar
Erstad, D.J. and Cusack, J.C. (2014). Mutational analysis of merkel cell carcinoma. Cancers, 17, 2116–36.Google Scholar
Elbashier, S.H., Nazarina, A.R., and Looi, L.M. (2013). Cytokeratin immunoreactivity in Ewing sarcoma/primitive neuroectodermal tumor. Malays J Pathol, 35, 139–45.Google Scholar
Zhang, P.J., Barcos, M., Stewart, C.C., et al. (2000). Immunoreactivity of MIC2 (CD99) in acute myelogenous leukemia and related diseases. Mod Pathol, 13, 452–8.Google Scholar
Pozdnyakova, O. and Mahalingam, M. (2008). CD99 – much ado about nothing? J Cutan Pathol, 35, 86–7.Google Scholar
Dehner, L.P. (1993). Primitive neuroectodermal tumor and Ewing's sarcoma. Am J Surg Pathol, 17, 113.Google Scholar
Sandberg, A.A. and Bridge, J.A. (2000). Update on cytogenetics and molecular genetics of bone and soft tissue tumors: Ewing sarcoma and peripheral primitive neuroectodermal tumors. Cancer Genet Cytogenet, 123, 126.Google Scholar
Delattre, O., Zucman, J., Melot, T., et al. (1994). The Ewing's family of tumors – a subgroup of small round cell tumors defined by specific chimeric transcripts. N Eng J Med, 331, 249–99.Google Scholar
Downing, J.R., Head, D.R., Parham, D.M., et al. (1993). Detection of the (11;22)(q24;q12)translocation of Ewing's sarcoma and peripheral neuroectodermal tumors by reverse transcription polymerase chain reaction. Am J Pathol, 143, 1294.Google Scholar
Hirose, T., Hasegawa, T., Kudo, E., et al. (1992). Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features. Hum Pathol, 23, 865–70Google Scholar
Zhou, H., Coffin, C.M., Perkins, S.L., et al. (2003). Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype and cell cycle/growth activation marker expression in sporadic and NF-1 related lesions. Am J Surg Pathol, 27, 1337–45.Google Scholar
Rahrmann, E. P., Watson, A. L., Keng, V. W., et al. (2013). Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nat Genet, 45, 756–66.Google Scholar
Fisher, C., Carter, R. L., Ramachandra, S., et al. (1992). Peripheral nerve sheath differentiation in malignant soft tissue tumors: an ultrastructural and immunohistochemical study. Histopathology, 20, 115–26.Google Scholar
Storlazzi, C. T., Brekke, H. R., Mandahl, N., et al. (2006). Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumors. J Pathol, 209, 492500.Google Scholar

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