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Chapter 22 - Hodgkin Lymphoma

from Section V - Mature Lymphoid Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Hodgkin lymphoma (HL) is a family of unique B-lineage lymphoma subtypes and encompasses two morphologically, immunophenotypically, and clinically distinct categories: classic Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). HL usually affects the lymph nodes and is composed of a small number of large, dysplastic mononuclear and multinucleated neoplastic cells (Hodgkin/Reed-Sternberg [HRS] cells, or lymphocyte-predominant [LP] cells/lymphocytic and histiocytic [L&H] cells) set in the background of benign inflammatory elements with or without abundant band-like and/or more diffuse collagen fibrosis. The neoplastic cells are often surrounded by T-lymphocytes [1,2].

The difference between NLPHL and CHL is that the B-cell program is generally preserved, and the neoplastic cells exhibit the overt B-lineage phenotype in NLPHL, but the neoplastic cells in CHL display an aberrant differentiation program with a characteristic CD15+, CD30+, and CD45– immunophenotype [1,2].

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Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 285 - 295
Publisher: Cambridge University Press
Print publication year: 2024

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References

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