Book contents
- Frontmatter
- Contents
- Contributors
- Progress in Neurotherapeutics and Neuropsychopharmacology 2008
- Triflusal versus Aspirin for the Prevention of Stroke
- The Argatroban and tPA Stroke Study
- Use of Selegiline as Monotherapy and in Combination with Levodopa in the Management of Parkinson's Disease: Perspectives from the MONOCOMB Study
- Ropinirole 24-h Prolonged Release in Advanced Parkinson Disease: Review of a Randomized, Double-Blind, Placebo-Controlled Study (EASE PD-Adjunct Study)
- Insulin Resistance Alzheimer's Disease: Pathophysiology and Treatment
- Targeting Amyloid with Tramiprosate in Patients with Mild-to-Moderate Alzheimer Disease
- Intranasal Zolmitriptan Is Effective and Well Tolerated in Acute Cluster Headache: A Randomized Placebo-Controlled Double-Blind Crossover Study
- Optimal Dosing of Immunomodulating Drugs: A Dose-Comparison Study of GA in RRMS
- Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease
- Randomized Clinical Trials of Pregabalin for Neuropathic Pain: Methods, Results, and Implications
- Effect of Methylphenidate in Patients with Acute Traumatic Brain Injury; a Randomized Clinical Trial
- Improvement in Speeded Cognitive Processing After Anti-epileptic Drug Withdrawal–A Controlled Study in Mono-therapy Patients
- A Randomized-Controlled Trial of Bilateral rTMS for Treatment-Resistant Depression
- Serotonin Related Genes Affect Antidepressant Treatment in Obsessive–Compulsive Disorder
- Night Eating Syndrome and Results from the First Placebo-Controlled Trial of Treatment, with the SSRI Medication, Sertraline: Implications for Clinical Practice
- Modafinil: A Candidate for Pharmacotherapy of Negative Symptoms in Schizophrenia
- New Approaches to Treatment of Schizophrenia by Enhancing N-methyl-D-aspartate Neurotransmission
- Subject Index
- Author Index
Randomized Clinical Trials of Pregabalin for Neuropathic Pain: Methods, Results, and Implications
Published online by Cambridge University Press: 13 May 2010
- Frontmatter
- Contents
- Contributors
- Progress in Neurotherapeutics and Neuropsychopharmacology 2008
- Triflusal versus Aspirin for the Prevention of Stroke
- The Argatroban and tPA Stroke Study
- Use of Selegiline as Monotherapy and in Combination with Levodopa in the Management of Parkinson's Disease: Perspectives from the MONOCOMB Study
- Ropinirole 24-h Prolonged Release in Advanced Parkinson Disease: Review of a Randomized, Double-Blind, Placebo-Controlled Study (EASE PD-Adjunct Study)
- Insulin Resistance Alzheimer's Disease: Pathophysiology and Treatment
- Targeting Amyloid with Tramiprosate in Patients with Mild-to-Moderate Alzheimer Disease
- Intranasal Zolmitriptan Is Effective and Well Tolerated in Acute Cluster Headache: A Randomized Placebo-Controlled Double-Blind Crossover Study
- Optimal Dosing of Immunomodulating Drugs: A Dose-Comparison Study of GA in RRMS
- Tetrathiomolybdate versus Trientine in the Initial Treatment of Neurologic Wilson's Disease
- Randomized Clinical Trials of Pregabalin for Neuropathic Pain: Methods, Results, and Implications
- Effect of Methylphenidate in Patients with Acute Traumatic Brain Injury; a Randomized Clinical Trial
- Improvement in Speeded Cognitive Processing After Anti-epileptic Drug Withdrawal–A Controlled Study in Mono-therapy Patients
- A Randomized-Controlled Trial of Bilateral rTMS for Treatment-Resistant Depression
- Serotonin Related Genes Affect Antidepressant Treatment in Obsessive–Compulsive Disorder
- Night Eating Syndrome and Results from the First Placebo-Controlled Trial of Treatment, with the SSRI Medication, Sertraline: Implications for Clinical Practice
- Modafinil: A Candidate for Pharmacotherapy of Negative Symptoms in Schizophrenia
- New Approaches to Treatment of Schizophrenia by Enhancing N-methyl-D-aspartate Neurotransmission
- Subject Index
- Author Index
Summary
Key words: diabetic peripheral neuropathy, neuropathic pain, postherpetic neuralgia, pregabalin, randomized clinical trials, spinal cord injury.
Introduction and Overview
Neuropathic pain is caused by lesions or diseases affecting somatosensory pathways within the peripheral or central nervous system (IASP Special Interest Group on Neuropathic Pain, 2006; Merskey & Bogduk, 1994). Chronic neuropathic pain is common in clinical practice, and patients with conditions such as diabetic peripheral neuropathy (DPN), HIV sensory neuropathy, and spinal cord injury suffer from neuropathic pain that impairs their health-related quality of life, causing physical disability and emotional distress (Jensen et al., 2007). The distinction between neuropathic pain and non-neuropathic inflammatory or musculoskeletal pain is important because it reflects at least partially distinct pathophysiologic mechanisms and somewhat different patterns of treatment efficacy. Neuropathic pain can be diagnosed based on a medical history of a nervous system lesion or disease consistent with the patient's report of pain and neurological examination findings of negative and positive sensory phenomena in the same area innervated by damaged nervous system pathways (Dworkin et al., 2003a).
Chronic neuropathic pain is more common than generally appreciated, with as many as three million patients with painful DPN (Schmader, 2002) and one million patients with postherpetic neuralgia (PHN) (Bowsher, 1999) in the United States. Until relatively recently, there were few treatments available with established efficacy for patients with chronic neuropathic pain. On the basis of results from randomized placebo-controlled trials published within the past several years (Dworkin et al., in press; Finnerup et al., 2005), an evidence-based treatment approach for patients with chronic neuropathic pain is now possible.
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- Progress in Neurotherapeutics and Neuropsychopharmacology , pp. 167 - 188Publisher: Cambridge University PressPrint publication year: 2008
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