Pharmacogenomics and Psychopharmacology

doi:10.1017/9781911623465.007

Chapter 5 - Pharmacogenomics and Psychopharmacology

from Part 1 - Basic Science and General Principles

Published online by Cambridge University Press: 29 May 2020

Diego L. Lapetina ,

Esther H. Yang ,

Beatriz C. Henriques and

Katherine J. Aitchison

Edited by

Peter M. Haddad and

David J. Nutt

Show author details

Peter M. Haddad: Affiliation:
Hamad Medical Corporation, Qatar
David J. Nutt: Affiliation:
Centre for Neuropsychopharmacology, Division of Psychiatry, Department of Brain Sciences, Imperial College London

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Summary

While genome-wide association analysis and related multi-omic strategies have in recent years dominated the field of complex disorders including mental health and addictions, in pharmacogenomics, drug metabolizing enzymes show Mendelian patterns of inheritance with correspondingly large effect sizes. Consistent with this, genes encoding these enzymes make up the majority of the genes for which the strength of the association with clinical effect of psychiatric medications is sufficient to recommend clinical utility (Bousman et al., 2018). Moreover, such enzymes are expressed in the brain (Aitchison et al., 2010; Kalow & Tyndale, 1992). We herein provide a comprehensive review of the relevance of drug metabolizing enzyme and transporter genes to mental health and addictions.

Type: Chapter
Information: Seminars in Clinical Psychopharmacology , pp. 151 - 202

DOI: https://doi.org/10.1017/9781911623465.007 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2020

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Chapter 5 - Pharmacogenomics and Psychopharmacology

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