Moller, T R, Brorsson, B, Ceberg, J, et al. A prospective survey of radiotherapy practice 2001 in Sweden. Acta Oncol. 2003; 42:387–410.CrossRefGoogle ScholarPubMed

Slotman, B, Faivre-Finn, C, Kramer, G, et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med. 2007; 357:664–72.Google Scholar

Morris, B, Partap, S, Yeom, K, et al. Cerebrovascular disease in childhood cancer survivors: A children’s oncology group report. Neurology. 2009; 73:1906–13.CrossRefGoogle ScholarPubMed

Bowers, D C, Liu, Y, Leisenring, W, et al. Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: A report from the childhood cancer survivor study. J Clin Oncol. 2006; 24:5277–82.CrossRefGoogle ScholarPubMed

Campen, C J, Kranick, S M, Kasner, S E, et al. Cranial irradiation increases risk of stroke in pediatric brain tumor survivors. Stroke. 2012; 43:3035–40.Google Scholar

Grisold, W, Oberndorfer, S, Struhal, W. Stroke and cancer: A review. Acta Neurol Scand. 2009; 119:1–16.CrossRefGoogle ScholarPubMed

Labauge, P, Laberge, S, Brunereau, L, Levy, C, Tournier-Lasserve, E. Hereditary cerebral cavernous angiomas: Clinical and genetic features in 57 French families. Societe Francaise de Neurochirurgie. Lancet. 1998; 352:1892–7.Google Scholar

Gunel, M, Awad, I A, Finberg, K, et al. A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans. N Engl J Med. 1996; 334:946–51.Google Scholar

Laberge-le Couteulx, S, Jung, H H, Labauge, P, et al. Truncating mutations in ccm1, encoding krit1, cause hereditary cavernous angiomas. Nat Genet. 1999; 23:189–93.Google Scholar

Bergametti, F, Denier, C, Labauge, P, et al. Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. Am J Hum Genet. 2005; 76:42–51.CrossRefGoogle ScholarPubMed

Nimjee, S M, Powers, C J, Bulsara, K R. Review of the literature on de novo formation of cavernous malformations of the central nervous system after radiation therapy. Neurosurg Focus. 2006; 21:e4.Google Scholar

Lew, S M, Morgan, J N, Psaty, E, et al. Cumulative incidence of radiation-induced cavernomas in long-term survivors of medulloblastoma. J Neurosurg. 2006; 104:103–7.Google ScholarPubMed

Al-Shahi Salman, R, Hall, J M, Horne, M A, et al. Untreated clinical course of cerebral cavernous malformations: A prospective, population-based cohort study. Lancet Neurol. 2012; 11:217–24.Google Scholar

Kivelev, J, Niemela, M, Hernesniemi, J. Treatment strategies in cavernomas of the brain and spine. J Clin Neurosci. 2012; 19:491–7.Google ScholarPubMed

Niranjan, A, Lunsford, L D. Stereotactic radiosurgery guidelines for the management of patients with intracranial cavernous malformations. Prog Neurol Surg. 2013; 27:166–75.Google ScholarPubMed

Schneble, H M, Soumare, A, Herve, D, et al. Antithrombotic therapy and bleeding risk in a prospective cohort study of patients with cerebral cavernous malformations. Stroke. 2012; 43:3196–9.Google Scholar

de Weerd, M, Greving, J P, Hedblad, B, et al. Prevalence of asymptomatic carotid artery stenosis in the general population: An individual participant data meta-analysis. Stroke. 2010; 41:1294–7.CrossRefGoogle ScholarPubMed

Compter, A, van der Worp, H B, Algra, A, Kappelle, L J. Second manifestations of AdSG. Prevalence and prognosis of asymptomatic vertebral artery origin stenosis in patients with clinically manifest arterial disease. Stroke. 2011; 42:2795–800.CrossRefGoogle Scholar

Marquardt, L, Kuker, W, Chandratheva, A, Geraghty, O, Rothwell, P M. Incidence and prognosis of > or = 50% symptomatic vertebral or basilar artery stenosis: Prospective population-based study. Brain. 2009; 132:982–8.Google Scholar

Feldmann, E, Daneault, N, Kwan, E, et al. Chinese-White differences in the distribution of occlusive cerebrovascular disease. Neurology. 1990; 40:1541–5.CrossRefGoogle ScholarPubMed

Plummer, C, Henderson, R D, O’Sullivan, J D, Read, S J. Ischemic stroke and transient ischemic attack after head and neck radiotherapy: A review. Stroke. 2011; 42:2410–18.Google Scholar

Scott, A S, Parr, L A, Johnstone, P A. Risk of cerebrovascular events after neck and supraclavicular radiotherapy: A systematic review. Radiother Oncol. 2009; 90:163–5.Google Scholar

Jagsi, R, Griffith, K A, Koelling, T, Roberts, R, Pierce, L J. Stroke rates and risk factors in patients treated with radiation therapy for early-stage breast cancer. J Clin Oncol. 2006; 24:2779–85.Google Scholar

Nilsson, G, Holmberg, L, Garmo, H, Terent, A, Blomqvist, C. Increased incidence of stroke in women with breast cancer. Eur J Cancer. 2005; 41:423–9.Google Scholar

Nilsson, G, Holmberg, L, Garmo, H, Terent, A, Blomqvist, C. Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke. Br J Cancer. 2009; 100:811–16.Google Scholar

Hooning, M J, Dorresteijn, L D, Aleman, B M, et al. Decreased risk of stroke among 10-year survivors of breast cancer. J Clin Oncol. 2006; 24:5388–94.Google Scholar

Zou, W X, Leung, T W, Yu, S C, et al. Angiographic features, collaterals, and infarct topography of symptomatic occlusive radiation vasculopathy: A case-referent study. Stroke. 2013; 44:401–6.Google Scholar

Murros, K E, Toole, J F. The effect of radiation on carotid arteries. A review article. Arch Neurol. 1989; 46:449–55.CrossRefGoogle ScholarPubMed

O’Connor, M M, Mayberg, M R. Effects of radiation on cerebral vasculature: A review. Neurosurgery. 2000; 46:138–49.Google Scholar

Fokkema, M, den Hartog, A G, Bots, M L, et al. Stenting versus surgery in patients with carotid stenosis after previous cervical radiation therapy: Systematic review and meta-analysis. Stroke. 2012; 43:793–801.Google Scholar

Abbott, A L. Carotid surgery or stenting following neck irradiation: Time to address the assumptions. Eur J Vasc Endovasc Surg. 2012; 43:8–9.Google Scholar

McDonald, M W, Moore, M G, Johnstone, P A. Risk of carotid blowout after reirradiation of the head and neck: A systematic review. Int J Radiat Oncol Biol Phys. 2012; 82:1083–9.Google Scholar

Haas, R A, Ahn, S H. Interventional management of head and neck emergencies: Carotid blowout. Semin Intervent Radiol. 2013; 30:245–8.Google Scholar

Bowers, D C, Mulne, A F, Reisch, J S, et al. Nonperioperative strokes in children with central nervous system tumors. Cancer. 2002; 94:1094–101.CrossRefGoogle ScholarPubMed

Grill, J, Couanet, D, Cappelli, C, et al. Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma. Ann Neurol. 1999; 45:393–6.3.0.CO;2-B>CrossRefGoogle ScholarPubMed

Erridge, S C, Conkey, D S, Stockton, D, et al. Radiotherapy for pituitary adenomas: Long-term efficacy and toxicity. Radiother Oncol. 2009; 93:597–601.Google Scholar

Flickinger, J C, Nelson, P B, Taylor, F H, Robinson, A. Incidence of cerebral infarction after radiotherapy for pituitary adenoma. Cancer. 1989; 63:2404–8.Google Scholar

Bowen, J, Paulsen, C A. Stroke after pituitary irradiation. Stroke. 1992; 23:908–11.Google Scholar

Brada, M, Burchell, L, Ashley, S, Traish, D. The incidence of cerebrovascular accidents in patients with pituitary adenoma. Int J Radiat Oncol Biol Phys. 1999; 45:693–8.Google Scholar

Bailey, E L, Smith, C, Sudlow, C L, Wardlaw, J M. Pathology of lacunar ischemic stroke in humans: A systematic review. Brain Pathol. 2012; 22:583–91.Google Scholar

Millikan, C, Futrell, N. The fallacy of the lacune hypothesis. Stroke. 1990; 21:1251–7.Google Scholar

Futrell, N. Lacunar infarction: Embolism is the key. Stroke. 2004; 35:1778–9.Google Scholar

Futrell, N, Millikan, C, Watson, B D, Dietrich, W D, Ginsberg, M D. Embolic stroke from a carotid arterial source in the rat: Pathology and clinical implications. Neurology. 1989; 39:1050–6.Google Scholar

Norrving, B. Lacunar infarcts: No black holes in the brain are benign. Pract Neurol. 2008; 8:222–8.Google Scholar

Patel, B, Markus, H S. Magnetic resonance imaging in cerebral small vessel disease and its use as a surrogate disease marker. Int J Stroke. 2011; 6:47–59.Google Scholar

Kwee, R M, Kwee, T C. Virchow–Robin spaces at MR imaging. Radiographics. 2007; 27:1071–86.Google Scholar

Gouw, A A, Seewann, A, van der Flier, W M, et al. Heterogeneity of small vessel disease: A systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry. 2011; 82:126–35.Google Scholar

Atwood, L D, Wolf, P A, Heard-Costa, N L, et al. Genetic variation in white matter hyperintensity volume in the Framingham study. Stroke. 2004; 35:1609–13.Google Scholar

Fornage, M, Debette, S, Bis, J C, et al. Genome-wide association studies of cerebral white matter lesion burden: The charge consortium. Ann Neurol. 2011; 69:928–39.Google Scholar

Debette, S, Markus, H S. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis. BMJ. 2010; 341:c3666.Google Scholar

Ebi, J, Sato, H, Nakajima, M, Shishido, F. Incidence of leukoencephalopathy after whole-brain radiation therapy for brain metastases. Int J Radiat Oncol Biol Phys. 2012.Google Scholar

DeAngelis, L M, Delattre, J Y, Posner, J B. Radiation-induced dementia in patients cured of brain metastases. Neurology. 1989; 39:789–96.CrossRefGoogle ScholarPubMed

Schrag, M, McAuley, G, Pomakian, J, et al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: A postmortem MRI study. Acta Neuropathol. 2010; 119:291–302.Google Scholar

Fazekas, F, Kleinert, R, Roob, G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: Evidence of microangiopathy-related microbleeds. Am J Neuroradiol. 1999; 20:637–42.Google Scholar

Fisher, M, French, S, Ji, P, Kim, R C. Cerebral microbleeds in the elderly: A pathological analysis. Stroke. 2010; 41:2782–5.Google Scholar

Schrag, M, McAuley, G, Pomakian, J, et al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: A postmortem MRI study. Acta Neuropathol. 2009.Google Scholar

Greenberg, S M, Vernooij, M W, Cordonnier, C, et al. Cerebral microbleeds: A guide to detection and interpretation. Lancet Neurol. 2009; 8:165–74.Google Scholar

Roob, G, Schmidt, R, Kapeller, P, et al. MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology. 1999; 52:991–4.Google Scholar

Vernooij, M W, van der Lugt, A, Ikram, M A, et al. Prevalence and risk factors of cerebral microbleeds: The Rotterdam scan study. Neurology. 2008; 70:1208–14.Google Scholar

Benavente, O R, Hart, R G, McClure, L A, et al. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012; 367:817–25.Google Scholar

Brisman, J L, Song, J K, Newell, D W. Cerebral aneurysms. N Engl J Med. 2006; 355:928–39.Google Scholar

van Gijn, J, Kerr, R S, Rinkel, G J. Subarachnoid haemorrhage. Lancet. 2007; 369:306–18.CrossRefGoogle ScholarPubMed

Vernooij, M W, Ikram, M A, Tanghe, H L, et al. Incidental findings on brain MRI in the general population. N Engl J Med. 2007; 357:1821–8.Google Scholar

Feigin, V L, Rinkel, G J, Lawes, C M, et al. Risk factors for subarachnoid hemorrhage: An updated systematic review of epidemiological studies. Stroke. 2005; 36:2773–80.Google Scholar

Wiebers, D O, Whisnant, J P, Huston, J 3rd, et al. Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003; 362:103–10.Google Scholar

Lau, W Y, Chow, C K. Radiation-induced petrous internal carotid artery aneurysm. Ann Otol Rhinol Laryngol. 2005; 114:939–40.Google Scholar

Sciubba, D M, Gallia, G L, Recinos, P, Garonzik, I M, Clatterbuck, R E. Intracranial aneurysm following radiation therapy during childhood for a brain tumor. Case report and review of the literature. J Neurosurg. 2006; 105:134–9.Google Scholar

Kuroda, S, Houkin, K. Moyamoya disease: Current concepts and future perspectives. Lancet Neurol. 2008; 7:1056–66.Google Scholar

Liu, W, Morito, D, Takashima, S, et al. Identification of rnf213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One. 2011; 6:e22542.Google Scholar

Kamada, F, Aoki, Y, Narisawa, A, et al. A genome-wide association study identifies rnf213 as the first moyamoya disease gene. J Hum Genet. 2011; 56:34–40.Google Scholar

Kestle, J R, Hoffman, H J, Mock, A R. Moyamoya phenomenon after radiation for optic glioma. J Neurosurg. 1993; 79:32–5.Google Scholar

Ullrich, N J, Robertson, R, Kinnamon, D D, et al. Moyamoya following cranial irradiation for primary brain tumors in children. Neurology. 2007; 68:932–8.Google Scholar

Pandey, P, Steinberg, G K. Neurosurgical advances in the treatment of moyamoya disease. Stroke. 2011; 42:3304–10.Google Scholar

Shuper, A, Packer, R J, Vezina, L G, Nicholson, H S, Lafond, D. ‘Complicated migraine-like episodes’ in children following cranial irradiation and chemotherapy. Neurology. 1995; 45:1837–40.Google Scholar

Black, D F, Morris, J M, Lindell, E P, et al. Stroke-like migraine attacks after radiation therapy (SMART) syndrome is not always completely reversible: A case series. Am J Neuroradiol. 2013; 34:2298–303.Google Scholar

Tomek, M, Bhavsar, S V, Patry, D, Hanson, A. The syndrome of stroke-like migraine attacks after radiation therapy associated with prolonged unresponsiveness in an adult patient. Neurologist. 2015; 19:49–52.Google Scholar

Armstrong, A E, Gillan, E, DiMario, F J Jr. SMART syndrome (stroke-like migraine attacks after radiation therapy) in adult and pediatric patients. J Child Neurol. 2014; 29:336–41.Google Scholar

Farid, K, Meissner, W G, Samier-Foubert, A, et al. Normal cerebrovascular reactivity in stroke-like migraine attacks after radiation therapy syndrome. Clin Nucl Med. 2010; 35:583–5.Google Scholar

Smith, G L, Smith, B D, Buchholz, T A, et al. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol. 2008; 26:5119–25.Google Scholar

Haynes, J C, Machtay, M, Weber, R S, et al. Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation. Laryngoscope. 2002; 112:1883–7.Google Scholar

Dorresteijn, L D, Kappelle, A C, Boogerd, W, et al. Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years. J Clin Oncol. 2002; 20:282–8.Google Scholar

Elerding, S C, Fernandez, R N, Grotta, J C, et al. Carotid artery disease following external cervical irradiation. Ann Surg. 1981; 194:609–15.Google Scholar

De Bruin, M L, Dorresteijn, L D, van’t Veer, M B, et al. Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst. 2009; 101:928–37.Google Scholar

Moser, E C, Noordijk, E M, van Leeuwen, F E, et al. Long-term risk of cardiovascular disease after treatment for aggressive non-Hodgkin lymphoma. Blood. 2006; 107:2912–19.Google Scholar

Schievink, W I. Spontaneous dissection of the carotid and vertebral arteries. N Engl J Med. 2001; 344:898–906.Google Scholar

Ferro, J M, Massaro, A R, Mas, J L. Aetiological diagnosis of ischaemic stroke in young adults. Lancet Neurol. 2010; 9:1085–96.Google Scholar

Longoni, M, Grond-Ginsbach, C, Grau, A J, et al. The ICAM-1 E469 K gene polymorphism is a risk factor for spontaneous cervical artery dissection. Neurology. 2006; 66:1273–5.CrossRefGoogle Scholar

Pezzini, A, Del Zotto, E, Archetti, S, et al. Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke. Stroke. 2002; 33:664–9.Google Scholar

Gallai, V, Caso, V, Paciaroni, M, et al. Mild hyperhomocyst(e)inemia: a possible risk factor for cervical artery dissection. Stroke. 2001; 32:714–18.Google Scholar

Konrad, C, Muller, G A, Langer, C, et al. Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections. J Neurol. 2004; 251:1242–8.Google Scholar

Silbert, P L, Mokri, B, Schievink, W I. Headache and neck pain in spontaneous internal carotid and vertebral artery dissections. Neurology. 1995; 45:1517–22.Google Scholar

Lee, V H, Brown, R D Jr., Mandrekar, J N, Mokri, B. Incidence and outcome of cervical artery dissection: a population-based study. Neurology. 2006; 67:1809–12.CrossRefGoogle ScholarPubMed

Mokri, B, Silbert, P L, Schievink, W I, Piepgras, D G. Cranial nerve palsy in spontaneous dissection of the extracranial internal carotid artery. Neurology. 1996;46:356–9.Google Scholar

Arnold, M, Cumurciuc, R, Stapf, C, et al. Pain as the only symptom of cervical artery dissection. J Neurol Neurosurg Psychiatry. 2006; 77:1021–4.Google Scholar

Biousse, V, D’Anglejan-Chatillon, J, Touboul, P J, Amarenco, P, Bousser, M G. Time course of symptoms in extracranial carotid artery dissections. A series of 80 patients. Stroke. 1995; 26:235–9.Google Scholar

Saeed, A B, Shuaib, A, Al-Sulaiti, G, Emery, D. Vertebral artery dissection: Warning symptoms, clinical features and prognosis in 26 patients. Can J Neurol Sci. 2000; 27:292–6.Google Scholar

Hurwitz, E L, Aker, P D, Adams, A H, Meeker, W C, Shekelle, P G. Manipulation and mobilization of the cervical spine. A systematic review of the literature. Spine. 1996; 21:1746–60.Google Scholar

Haldeman, S, Carey, P, Townsend, M, Papadopoulos, C. Arterial dissections following cervical manipulation: the chiropractic experience. CMAJ. 2001; 165:905–6.Google Scholar

Thornton, R V. Malpractice: death resulting from chiropractic treatment of headache (medicolegal abstract). JAMA. 1934; 103:1260.Google Scholar

Haneline, M T, Croft, A C, Frishberg, B M. Association of internal carotid artery dissection and chiropractic manipulation. Neurologist. 2003; 9:35–44.Google Scholar

Dziewas, R, Konrad, C, Drager, B, et al. Cervical artery dissection: Clinical features, risk factors, therapy and outcome in 126 patients. J Neurol. 2003; 250:1179–84.Google Scholar

Lee, K P, Carlini, W G, McCormick, G F, Albers, G W. Neurologic complications following chiropractic manipulation: a survey of California neurologists. Neurology. 1995; 45:1213–15.Google Scholar

Norris, J W, Beletsky, V, Nadareishvili, Z G. Sudden neck movement and cervical artery dissection. The Canadian Stroke Consortium. CMAJ. 2000; 163:38–40.Google Scholar

Dabbs, V, Lauretti, W J. A risk assessment of cervical manipulation vs. NSAIDs for the treatment of neck pain. J Manipulative Physiol Ther. 1995; 18:530–6.Google Scholar

Haneline, M T, Lewkovich, G. Identification of internal carotid artery dissection in chiropractic practice. J Can Chiropr Assoc. 2004; 48:206–10.Google Scholar

Schievink, W I, Mokri, B, Whisnant, J P. Internal carotid artery dissection in a community. Rochester, Minnesota, 1987–1992. Stroke. 1993; 24:1678–80.Google Scholar

Giroud, M, Fayolle, H, Andre, N, et al. Incidence of internal carotid artery dissection in the community of Dijon. J Neurol Neurosurg Psychiatry. 1994; 57:1443.Google Scholar

Assendelft, W J, Bouter, L M, Knipschild, P G. Complications of spinal manipulation: A comprehensive review of the literature. J Fam Pract. 1996; 42:475–80.Google Scholar

Showalter, W, Esekogwu, V, Newton, K I, Henderson, S O. Vertebral artery dissection. Acad Emerg Med. 1997; 4:991–5.Google Scholar

Dvorak, J, Orelli, F V. How dangerous is manipulation to the cervical spine? Man Med. 1985; 2:1–4.Google Scholar

Klougart, N, Leboeuf-Yde, C, Rasmussen, L R. Safety in chiropractic practice, Part I; The occurrence of cerebrovascular accidents after manipulation to the neck in Denmark from 1978–1988. J Manipulative Physiol Ther. 1996; 19:371–7.Google Scholar

Haldeman, S, Carey, P, Townsend, M, Papadopoulos, C. Clinical perceptions of the risk of vertebral artery dissection after cervical manipulation: the effect of referral bias. Spine J. 2002; 2:334–42.Google Scholar

Haldeman, S, Kohlbeck, F J, McGregor, M. Unpredictability of cerebrovascular ischemia associated with cervical spine manipulation therapy: a review of sixty-four cases after cervical spine manipulation. Spine. 2002; 27:49–55.Google Scholar

Reuter, U, Hamling, M, Kavuk, I, Einhaupl, K M, Schielke, E. Vertebral artery dissections after chiropractic neck manipulation in Germany over three years. J Neurol. 2006; 253:724–30.Google Scholar

Haldeman, S, Kohlbeck, F J, McGregor, M. Stroke, cerebral artery dissection, and cervical spine manipulation therapy. J Neurol. 2002; 249:1098–104.CrossRefGoogle ScholarPubMed

Hufnagel, A, Hammers, A, Schonle, P W, Bohm, K D, Leonhardt, G. Stroke following chiropractic manipulation of the cervical spine. J Neurol. 1999; 246:683–8.Google Scholar

Rothwell, D M, Bondy, S J, Williams, J I. Chiropractic manipulation and stroke: a population-based case-control study. Stroke. 2001; 32:1054–60.Google Scholar

Whedon, J M, Song, Y, Mackenzie, T A, et al. Risk of stroke after chiropractic spinal manipulation in Medicare B beneficiaries aged 66 to 99 years with neck pain. J Manipulative Physiol Ther. 2015; 38:93–101.Google Scholar

Smith, W S, Johnston, S C, Skalabrin, E J, et al. Spinal manipulative therapy is an independent risk factor for vertebral artery dissection. Neurology. 2003; 60:1424–8.Google Scholar

Dittrich, R, Rohsbach, D, Heidbreder, A, et al. Mild mechanical traumas are possible risk factors for cervical artery dissection. Cerebrovasc Dis. 2007; 23:275–81.Google Scholar

Wynd, S, Westaway, M, Vohra, S, Kawchuk, G. The quality of reports on cervical arterial dissection following cervical spinal manipulation. PLoS One. 2013; 8:e59170.Google Scholar

Haynes, M J, Vincent, K, Fischhoff, C, et al. Assessing the risk of stroke from neck manipulation: A systematic review. Int J Clin Pract. 2012; 66:940–7.Google Scholar

Cassidy, J D, Boyle, E, Cote, P, et al. Risk of vertebrobasilar stroke and chiropractic care: results of a population-based case-control and case-crossover study. J Manipulative Physiol Ther. 2009; 32:S201–208.Google Scholar

Guillon, B, Berthet, K, Benslamia, L, et al. Infection and the risk of spontaneous cervical artery dissection: a case-control study. Stroke. 2003; 34:e79–81.Google Scholar

Cagnie, B, Barbaix, E, Vinck, E, D’Herde, K, Cambier, D. Atherosclerosis in the vertebral artery: an intrinsic risk factor in the use of spinal manipulation? Surg Radiol Anat. 2006; 28:129–34.Google Scholar

Pezzini, A, Del Zotto, E, Padovani, A. Hyperhomocysteinemia: a potential risk factor for cervical artery dissection following chiropractic manipulation of the cervical spine. J Neurol. 2002; 249:1401–3.Google Scholar

Frisoni, G B, Anzola, G P. Neck manipulation and stroke. Neurology. 1990; 40:1910.Google Scholar

Scott, A A, Welsh, R P. Fat embolism: A rational approach to treatment. Can Med Assoc J. 1973; 109(9):867–71.Google Scholar

Talbot, M, Schemitsch, E H. Fat embolism syndrome: History, definition, epidemiology. Injury. 2006; 37(Suppl 4):S3–S7.Google Scholar

Klingele, K, Bhalla, T, Sawardekar, A, Tobias, J D. Postoperative hypoxemia due to fat embolism. Saudi J Anaesth. 2011; 5(3):332–4.Google Scholar

Weisz, G M, Barzilai, A. Fat embolism: Physiopathology, diagnosis with management. Arch Orthop Unfall-Chir. 1975; 82(3):217–23.Google Scholar

Habashi, N M, Andrews, P L, Scalea, T M. Therapeutic aspects of fat embolism syndrome. Injury. 2006; 37(Suppl 4):S68–S73.Google Scholar

Fulde, G W, Harrison, P. Fat embolism: A review. Arch Emerg Med. 1991; 8(4):233–9.Google Scholar

Christie, J, Robinson, C M, Pell, A C, McBirnie, J, Burnett, R. Transcardiac echocardiography during invasive intramedullary procedures. J Bone Joint Surg Br. 1995; 77(3):450–5.Google Scholar

Gurd, A R, Wilson, R I. The fat embolism syndrome. J Bone Joint Surg Br. 1974; 56B(3):408–16.Google Scholar

Allardyce, D B, Meek, R N, Woodruff, B, Cassim, M M, Ellis, D. Increasing our knowledge of the pathogenesis of fat embolism: A prospective study of 43 patients with fractured femoral shafts. J Trauma. 1974; 14(11):955–62.Google Scholar

Bulger, E M, Smith, D G, Maier, R V, Jurkovich, G J. Fat embolism syndrome. A 10-year review. Arch Surg. 1997; 132(4):435–9.Google Scholar

Fabian, T C, Hoots, A V, Stanford, D S, Patterson, C R, Mangiante, E C. Fat embolism syndrome: Prospective evaluation in 92 fracture patients. Crit Care Med. 1990; 18(1):42–6.Google Scholar

Robert, J H, Hoffmeyer, P, Broquet, P E, Cerutti, P, Vasey, H. Fat embolism syndrome. Orthop Rev. 1993; 22(5):567–71.Google ScholarPubMed

Pinney, S J, Keating, J F, Meek, R N. Fat embolism syndrome in isolated femoral fractures: Does timing of nailing influence incidence? Injury. 1998; 29(2):131–3.Google Scholar

Campo-López, C, Flors-Villaverde, P, Calabuig-Alborch, J R. Fat embolism syndrome after bone fractures. Rev Clin Esp. 2012; 212(10):482–7.Google Scholar

Tsai, I T, Hsu, C J, Chen, Y H, et al. Fat embolism syndrome in long bone fracture–clinical experience in a tertiary referral center in Taiwan. J Chin Med Assoc. 2010; 73(8):407–10.Google Scholar

Talucci, R C, Manning, J, Lampard, S, Bach, A, Carrico, C J. Early intramedullary nailing of femoral shaft fractures: A cause of fat embolism syndrome. Am J Surg. 1983; 146(1):107–11.Google Scholar

Bone, L B, Johnson, K D, Weigelt, J, Scheinberg, R. Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am. 1989; 71(3):336–40.Google Scholar

Findlay, J M, DeMajo, W. Cerebral fat embolism. Can Med Assoc J. 1984; 131(7):755–7.Google Scholar

Taviloglu, K, Yanar, H. Fat embolism syndrome. Surg Today. 2007; 37(1):5–8.Google Scholar

Duja, C M, Berna, C, Kremer, S, et al. Confusion after spine injury: Cerebral fat embolism after traumatic rupture of a Tarlov cyst: Case report. BMC Emerg Med. 2010; 10:18.Google Scholar

Powers, K A, Talbot, L A. Case report: Fat embolism syndrome after femur fracture with intramedullary nailing. Am J Crit Care. 2011; 20:264–6.Google Scholar

Thienpont, E, Kaddar, S, Morrison, S. Paradoxical fat embolism after uncemented total hip arthroplasty: A case report. Acta Orthop Belg. 2007; 73(3):418–20.Google Scholar

Sasano, N, Ishida, S, Tetsu, S, et al. Cerebral fat embolism diagnosed by magnetic resonance imaging at one, eight, and 50 days after hip arthroplasty: A case report. Can J Anaesth. 2004; 51(9):875–987.Google Scholar

Rodriguez-Merchan, E C, Comin-Gomez, J A, Martinez-Chacon, J L. Cerebral embolism during revision arthroplasty of the hip. Acta Orthop Belg. 1995; 61(4):319–22.Google Scholar

Ammon, J T, Khalily, C, Lester, D K. Fatal cerebral emboli in the absence of a cardiac arterial-venous shunt: Case report. J Arthroplasty. 2007; 22(3):477–9.Google Scholar

Chang, R N, Kim, J H, Lee, H, et al. Cerebral fat embolism after bilateral total knee replacement arthroplasty: A case report. Korean J Anesthesiol. 2010; 59 Suppl:S207–S210.Google Scholar

Jenkins, K, Chung, F, Wennberg, R, Etchells, E E, Davey, R. Fat embolism syndrome and elective knee arthroplasty. Can J Anaesth. 2002; 49(1):19–24.Google Scholar

Lee, S C, Yoon, J Y, Nam, C H, et al. Cerebral fat embolism syndrome after simultaneous bilateral total knee arthroplasty: A case series. J Arthroplasty. 2012; 27(3):409–14.Google Scholar

Ghatak, N R, Sinnenberg, R J, deBlois, G G. Cerebral fat embolism following cardiac surgery. Stroke. 1983; 14(4):619–21.Google Scholar

Wang, H D, Zheng, J H, Deng, C L, Liu, Q Y, Yang, S L. Fat embolism syndromes following liposuction. Aesthetic Plast Surg. 2008; 32(5):731–6.Google Scholar

Laub, D R Jr. Fat embolism syndrome after liposuction: A case report and review of the literature. Ann Plast Surg. 1990; 25(1):48–52.Google Scholar

Richards, R R. Fat embolism syndrome. Can J Surg. 1997; 40(5):334–9.Google Scholar

Mossa-Basha, M, Izbudak, I, Gurda, G T, Aygun, N. Cerebral fat embolism syndrome in sickle cell anaemia/β-thalassemia: Importance of susceptibility-weighted MRI. Clin Radiol. 2012; 67(10):1023–6.Google Scholar

Barson, A J, Chistwick, M L, Doig, C M. Fat embolism in infancy after intravenous fat infusions. Arch Dis Child. 1978; 53(3):218–23.Google Scholar

Bhalla, A, Sachdev, A, Lehl, S S, Singh, R, D’Cruz, S. Cerebral fat embolism as a rare possible complication of traumatic pancreatitis. JOP. 2003; 4(4):155–7.Google Scholar

Guardia, S N, Bilbao, J M, Murray, D, Warren, R E, Sweet, J. Fat embolism in acute pancreatitis. Arch Pathol Lab Med. 1989; 113:503–6.Google Scholar

Dang, N C, Johnson, C, Eslami-Farsani, M, Haywood, L J. Bone marrow embolism in sickle cell disease: A review. Am J Hematol. 2005; 79(1):61–7.Google Scholar

Desselle, B C, O’Brien, T, Bugnitz, M, et al. Fatal fat embolism in a patient with sickle-beta+ thalassemia. Pediatr Hematol Oncol. 1995; 12(2):159–62.Google Scholar

ten Duis, H J. The fat embolism syndrome. Injury. 1997; 28(2):77–85.Google Scholar

Cox, G, Tzioupis, C, Calori, G M, et al. Cerebral fat emboli: A trigger of post-operative delirium. Injury. 2011; 42(S4):S6–S10.Google Scholar

Etchells, E E, Wong, D T, Davidson, G, Houston, P L. Fatal cerebral fat embolism associated with a patent foramen ovale. Chest. 1993; 104(3):962–3.Google Scholar

Gossling, H R, Pellegrini, V D Jr. Fat embolism syndrome: A review of the pathophysiology and physiological basis of treatment. Clin Orthop Relat Res. 1982; 165:68–82.Google Scholar

Butteriss, D J, Mahad, D, Soh, C, et al. Reversible cytotoxic cerebral edema in cerebral fat embolism. Am J Neuroradiol. 2006; 27(3):620–3.Google Scholar

Parisi, D M, Koval, K, Egol, K. Fat embolism syndrome. Am J Orthop. 2002; 31(9):507–12.Google Scholar

Adams, C B. The retinal manifestations of fat embolism. Injury. 1971; 2(3):221–4.Google Scholar

Murray, D G, Racz, G B. Fat embolism syndrome (respiratory insufficiency syndrome). A rationale for treatment. J Bone Joint Surg. 1974; 56(7):1338–49.Google Scholar

Koch, S, Forteza, A, Lavernia, C, et al. Cerebral fat microembolism and cognitive decline after hip and knee replacement. Stroke. 2007; 38(3):1079–81.Google Scholar

Sulek, C A, Davies, L K, Enneking, F K, Gearen, P A, Lobato, E B. Cerebral microembolism diagnosed by transcranial Doppler during total knee arthroplasty: Correlation with transesophageal echocardiography. Anesthesiology. 1999; 91(3):672–6.Google Scholar

Van Besouw, J P, Hinds, C J. Fat embolism syndrome. Br J Hosp Med. 1989; 42(4):304–6.Google Scholar

Finlay, M E, Benson, M D. Case report: Magnetic resonance imaging in cerebral fat embolism. Clin Radiol. 1996; 51(6):445–6.Google Scholar

Gombar, S, Dey, N, Deva, C. Pupillary signs in fat embolism syndrome. Acta Anaesthesiol Scand. 2005; 49(5):723.Google Scholar

Manousakis, G, Han, D Y, Backonja, M. Cognitive outcome of cerebral fat embolism. J Stroke Cerebrovasc Dis. 2012; 21(8):906–8.Google Scholar

Thomas, J E, Ayyar, D R. Systemic fat embolism. A diagnostic profile in 24 patients. Arch Neurol. 1972; 26(6):517–23.Google Scholar

Bardana, D, Rudan, J, Cervenko, F, Smith, R. Fat embolism syndrome in a patient demonstrating only neurologic symptoms. Can J Surg. 1998; 41(5):398–402.Google Scholar

Jacobson, D M, Terrence, C F, Reinmuth, O M. The neurologic manifestations of fat embolism. Neurology. 1986; 36:847–51.Google Scholar

Metting, Z, Rödiger, L A, Regtien, J G, van der Naalt, J. Delayed coma in head injury: consider cerebral fat embolism. Clin Neurol Neurosurg. 2009; 111(7):597–600.Google Scholar

Johnson, M J, Lucas, G L. Fat embolism syndrome. Orthopedics. 1996; 19(1):41–8.Google Scholar

Oh, W H, Mital, M A. Fat embolism: Current concepts of pathogenesis, diagnosis, and treatment. Orthop Clin North Am. 1978; 9(3):769–79.Google Scholar

Gurd, A R. Fat embolism: An aid to diagnosis. J Bone Joint Surg Br. 1970; 52(4):732–7.Google Scholar

Vedrinne, J M, Guillaume, C, Gagnieu, M C, et al. Bronchoalveolar lavage in trauma patients for diagnosis of fat embolism syndrome. Chest. 1992; 102(5):1323–7.Google Scholar

Weisz, G M, Rang, M, Salter, R B. Posttraumatic fat embolism in children: Review of the literature and of experience in the Hospital for Sick Children, Toronto. J Trauma. 1973; 13(6):529–34.Google Scholar

Schonfeld, S A, Ploysongsang, Y, DiLisio, R, et al. Fat embolism prophylaxis with corticosteroids. A prospective study in high-risk patients. Ann Intern Med. 1983; 99(4):438–43.Google Scholar

Lindeque, B G, Schoeman, H S, Dommisse, G F, Boeyens, M C, Vlok, A L. Fat embolism and the fat embolism syndrome. A double-blind therapeutic study. J Bone Joint Surg Br. 1987; 69(1):128–31.Google Scholar

Mellor, A, Soni, N. Fat embolism. Anaesthesia. 2001; 56(2):145–54.Google Scholar

Shaikh, N. Emergency management of fat embolism syndrome. J Emerg Trauma Shock. 2009; 2(1):29–33.Google Scholar

Costa, A N, Mendes, D M, Toufen, C, et al. Adult respiratory distress syndrome due to fat embolism in the postoperative period following liposuction and fat grafting. J Bras Pneumol. 2008; 34(8):622–5.Google Scholar

Chastre, J, Fagon, J Y, Soler, P, et al. Bronchoalveolar lavage for rapid diagnosis of the fat embolism syndrome in trauma patients. Ann Intern Med. 1990; 113(8):583–8.Google Scholar

Forteza, A M, Koch, S, Romano, J G, et al. Transcranial Doppler detection of fat emboli. Stroke. 1999; 30(12):2687–91.Google Scholar

Belvis, R, Leta, R G, Marti-Fabregas, J, et al. Almost perfect concordance between simultaneous transcranial Doppler and transesophageal echocardiography in the quantification of right-to-left shunts. J Neuroimaging. 2006; 16(2):133–8.Google Scholar

Forteza, A M, Koch, S, Campo-Bustillo, I, et al. Transcranial Doppler detection of cerebral fat emboli and relation to paradoxical embolism: A pilot study. Circulation. 2011; 123(18):1947–52.Google Scholar

Gupta, B, Kaur, M, d’Souza, N, et al. Cerebral fat embolism: A diagnostic challenge. Saudi J Anaesth. 2011; 5(3):348–52.Google Scholar

Salazar, J A, Romero, F, Padilla, F, Arboleda, J A, Fernández, O. Neurological manifestations of fat embolism syndrome. Neurologia. 1995; 10(2):65–9.Google Scholar

Sakamoto, T, Sawada, Y, Yukioka, T, et al. Computed tomography for diagnosis and assessment of cerebral fat embolism. Neuroradiology. 1983; 24(5):283–5.Google Scholar

Beers, G J, Nichols, G R, Willing, S J. CT demonstration of fat-embolism-associated hemorrhage in the anterior commissure. Am J Neuroradiol. 1988; 9(1):212–13.Google Scholar

Stoeger, A, Daniaux, M, Felber, S, et al. MRI findings in cerebral fat embolism. Eur Radiol. 1998; 8(9):1590–93.Google Scholar

Marshall, G B, Heale, V R, Herx, L, et al. Magnetic resonance diffusion weighted imaging in cerebral fat embolism. Can J Neurol Sci. 2004; 31(3):417–21.Google Scholar

Ryu, C W, Lee, D H, Kim, T K, et al. Cerebral fat embolism: Diffusion-weighted magnetic resonance imaging findings. Acta Radiol. 2005; 46(5):528–33.Google Scholar

Aravapalli, A, Fox, J, Lazaridis, C. Cerebral fat embolism and the ‘starfield’ pattern: A case report. Cases J. 2009; 2:212–14.Google Scholar

Pfeffer, G, Heran, M K. Restricted diffusion and poor clinical outcome in cerebral fat embolism syndrome. Can J Neurol Sci. 2010; 37(1):128–30.Google Scholar

Buskens, C J, Gratama, J W, Hogervorst, M, et al. Encephalopathy and MRI abnormalities in fat embolism syndrome: A case report. Med Sci Monit. 2008; 14(11):CS125–129.Google Scholar

Citerio, G, Bianchini, E, Beretta, L. Magnetic resonance imaging of cerebral fat embolism: A case report. Intensive Care Med. 1995; 21(8):679–81.Google Scholar

Yoshida, A, Okada, Y, Nagata, Y, Hanaguri, K, Morio, M. Assessment of cerebral fat embolism by magnetic resonance imaging in the acute stage. J Trauma. 1996; 40(3):437–40.Google Scholar

Simon, A D, Ulmer, J L, Strottmann, J M. Contrast-enhanced MR imaging of cerebral fat embolism: Case report and review of the literature. Am J Neuroradiol. 2003; 24(1):97–101.Google Scholar

Lee, J. Gradient-echo MRI in defining the severity of cerebral fat embolism. J Clin Neurol. 2008; 4(4):164–6.Google Scholar

Evert, A Eriksson, E A, Sarah, E et al. Cerebral fat embolism without intracardiac shunt: A novel presentation. Emerg Trauma Shock. 2011; 4(2):309–12.Google Scholar

Stoltenberg, J J, Gustilo, R B. The use of methylprednisolone and hypertonic glucose in the prophylaxis of fat embolism syndrome. Clin Orthop Relat Res. 1979; 143:211–21.Google Scholar

Kallenbach, J, Lewis, M, Zaltzman, M, et al. Low-dose corticosteroid prophylaxis against fat embolism. J Trauma. 1987; 27(10):1173–6.Google Scholar

Bederman, S S, Bhandari, M, McKee, M D, Schemitsch, E H. Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis. Can J Surg. 2009; 52(5):386–93.Google Scholar

Johnson, K D, Cadambi, A, Seibert, G B. Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: Effect of early operative stabilization of fractures. J Trauma. 1985; 25(5):375–84.Google Scholar

White, T, Petrisor, B A, Bhandari, M. Prevention of fat embolism syndrome. Injury. 2006; 37(Suppl 4):S59–67.Google Scholar

Muth, C M, Shank, E S. Gas embolism. N Engl J Med. 2000; 342(7):476–82.Google Scholar

Shaikh, N, Ummunisa, F. Acute management of vascular air embolism. J Emerg Trauma Shock. 2009; 2(3):180–5.Google Scholar

Green, B T, Tendler, D A. Cerebral air embolism during upper endoscopy: Case report and review. Gastrointest Endosc. 2005; 61(4):620–3.Google Scholar

Bou-Assaly, W, Pernicano, P, Hoeffner, E. Systemic air embolism after transthoracic lung biopsy: A case report and review of literature. World J Radiol. 2010; 2(5):193–6.Google Scholar

Mirski, M A, Lele, A V, Fitzsimmons, L, Toung, T J. Diagnosis and treatment of vascular air embolism. Anesthesiology. 2007; 106(1):164–77.Google Scholar

Herron, D M, Vernon, J K, Gryska, P V, Reines, H D. Venous gas embolism during endoscopy. Surg Endosc. 1999; 13(3):276–9.Google Scholar

Kashuk, J L, Penn, I. Air embolism after central venous catheterization. Surg Gynecol Obstet. 1984; 159(3):249–52.Google Scholar

Leach, R M, Rees, P J, Wilmshurst, P. Hyperbaric oxygen therapy. BMJ. 1998; 317(7166):1140–3.Google Scholar

Standefer, M, Bay, J W, Trusso, R. The sitting position in neurosurgery: A retrospective analysis of 488 cases. Neurosurgery. 1984; 14(6):649–58.Google Scholar

Papadopoulos, G, Kuhly, P, Brock, M, et al. Venous and paradoxical air embolism in the sitting position. A prospective study with transoesophageal echocardiography. Acta Neurochir. 1994; 126(2–4):140–3.Google Scholar

Ngai, S H, Stinchfield, F E, Triner, L. Air embolism during total hip arthroplasties. Anesthesiology. 1974; 40(4):405–7.Google Scholar

Spiess, B D, Sloan, M S, McCarthy, R J, et al. The incidence of venous air embolism during total hip arthroplasty. J Clin Anesth. 1988; 1(1):25–30.Google Scholar

Lew, T W, Tay, D H, Thomas, E. Venous air embolism during cesarean section: More common than previously thought. Anesth Analg. 1993; 77(3):448–52.Google Scholar

Nishiyama, T, Hanaoka, K. Gas embolism during hysteroscopy. Can J Anaesth. 1999; 46(4):379–81.Google Scholar

Chang, J L, Skolnick, K, Bedger, R, Schramm, V, Bleyaert, A L. Postoperative venous air embolism after removal of neck drains. Arch Otolaryngol. 1981; 107(8):494–6.Google Scholar

Ledowski, T, Kiese, F, Jeglin, S, Scholz, J. Possible air embolism during eye surgery. Anesth Analg. 2005; 100(6):1651–2.Google Scholar

Suzuki, K, Ueda, M, Abe, A, et al. Paradoxical cerebral air embolism occurred with postural change during rehabilitation, in a patient with ipsilateral internal carotid artery occlusion. Intern Med. 2012; 51(9):1107–9.Google Scholar

Timpa, J G, O’Meara, C, McIlwain, R B, Dabal, R J, Alten, J A. Massive systemic air embolism during extracorporeal membrane oxygenation support of a neonate with acute respiratory distress syndrome after cardiac surgery. J Extra Corpor Technol. 2011; 43(2):86–8.Google Scholar

Ueda, K, Kaneda, Y, Sudo, M, et al. Cerebral air embolism during imaging of a sentinel lymphatic drainage in the respiratory tract. Ann Thorac Surg. 2006; 81(2):721–3.Google Scholar

Singh, A, Ramanakumar, A, Hannan, J. Simultaneous left ventricular and cerebral artery air embolism after computed tomographic-guided transthoracic needle biopsy of the lung. Tex Heart Inst J. 2011; 38(4):424–6.Google Scholar

Le Guen, M, Trebbia, G, Sage, E, Cerf, C, Fischler, M. Intraoperative cerebral air embolism during lung transplantation: Treatment with early hyperbaric oxygen therapy. J Cardiothorac Vasc Anesth. 2012; 26(6):1077–9.Google Scholar

Frasco, P E, Caswell, R E, Novicki, D. Venous air embolism during transurethral resection of the prostate. Anesth Analg. 2004; 99(6):1864–6.Google Scholar

Tsou, M Y, Teng, Y H, Chow, L H, Ho, C M, Tsai, S K. Fatal gas embolism during transurethral incision of the bladder neck under spinal anesthesia. Anesth Analg. 2003; 97(6):1833–4.Google Scholar

Nayagam, J, Ho, K M, Liang, J. Fatal systemic air embolism during endoscopic retrograde cholangio-pancreatography. Anaesth Intensive Care. 2004; 32(2):260–4.Google Scholar

Akhtar, N, Jafri, W, Mozaffar, T. Cerebral artery air embolism following an esophagogastroscopy: A case report. Neurology. 2001; 56(1):136–7.Google Scholar

Katzgraber, F, Glenewinkel, F, Rittner, C, Beule, J. Fatal air embolism resulting from gastroscopy. Lancet. 1995; 346:1714–15.Google Scholar

Lowdon, J D, Tidmore, T L Jr. Fatal air embolism after gastrointestinal endoscopy. Anesthesiology. 1988; 69(4):622–3.Google Scholar

Zini, A, Carpeggiani, P, Pinelli, G, Nichelli, P. Brain air embolism secondary to atrial-esophageal fistula. Arch Neurol. 2012; 69(6):785.Google Scholar

Williams, T L, Parikh, D R, Hopkin, J R, et al. Teaching neuroimages: Cerebral air embolism secondary to atrial-esophageal fistula. Neurology. 2009; 72(12):e54–55.Google Scholar

Hertz, J A, Schinco, M A, Frykberg, E R. Extensive pneumocranium. J Trauma. 2002; 52(1):188.Google Scholar

Laskey, A L, Dyer, C, Tobias, J D. Venous air embolism during home infusion therapy. Pediatrics. 2002; 109(1):1–3.Google Scholar

Grace, D M. Air embolism with neurologic complications: A potential hazard of central venous catheters. Can J Surg. 1977; 20(1):51–3.Google Scholar

Seeburger, J, Borger, M A, Merk, D R, et al. Massive cerebral air embolism after bronchoscopy and central line manipulation. Asian Cardiovasc Thorac Ann. 2009; 17(1):67–9.Google Scholar

Clark, D K, Plaizier, E. Devastating cerebral air embolism after central line removal. J Neurosci Nurs. 2011; 43(4):193–6.Google Scholar

Yee, E S, Verrier, E D, Thomas, A N. Management of air embolism in blunt and penetrating thoracic trauma. J Thorac Cardiovasc Surg. 1983; 85(5):661–8.Google Scholar

Lai, C C, Chuang, C H, Chao, C M, Liu, W L, Hou, C C. Pulmonary artery air embolism after blunt trauma. Resuscitation. 2011; 82(4):369–70.Google Scholar

Hwang, S L, Lieu, A S, Lin, C L, et al. Massive cerebral air embolism after cardiopulmonary resuscitation. J Clin Neurosci. 2005; 12(4):468–9.Google Scholar

Arena, V, Capelli, A. Venous air embolism after cardiopulmonary resuscitation: The first case with histological confirmation. Cardiovasc Pathol. 2010; 19(2):43–4.Google Scholar

Schwerzmann, M, Seiler, C. Recreational scuba diving, patent foramen ovale and their associated risks. Swiss Med Wkly. 2001; 131(25–26): 365–74.Google Scholar

Spira, A. Diving and marine medicine review part II: Diving diseases. J Travel Med. 1999; 6(3):180–98.Google Scholar

Kapoor, T, Gutierrez, G. Air embolism as a cause of the systemic inflammatory response syndrome: A case report. Crit Care. 2003; 7(5):98–100.Google Scholar

Alvaran, S B, Toung, J K, Graff, T E, Benson, D W. Venous air embolism: Comparative merits of external cardiac massage, intracardiac aspiration, and left lateral decubitus position. Anesth Analg. 1978; 57(2):166–70.Google Scholar

Toung, T J, Rossberg, M I, Hutchins, G M. Volume of air in a lethal venous air embolism. Anesthesiology. 2001; 94(2):360–1.Google Scholar

Vann, R D, Butler, F K, Mitchell, S J, Moon, R E. Decompression illness. Lancet. 2011; 377(9760):153–64.Google Scholar

Raju, G S, Bendixen, B H, Khan, J, Summers, R W. Cerebrovascular accident during endoscopy: Consider cerebral air embolism, a rapidly reversible event with hyperbaric oxygen therapy. Gastrointest Endosc. 1998; 47(1):70–3.Google Scholar

Gursoy, S, Duger, C, Kaygusuz, K, et al. Cerebral arterial air embolism associated with mechanical ventilation and deep tracheal aspiration. Case Rep Pulmonol. 2012; 2012:1–2.Google Scholar

Heckmann, J G, Lang, C J, Kindler, K, et al. Neurologic manifestations of cerebral air embolism as a complication of central venous catheterization. Crit Care Med. 2000; 28(5):1621–5.Google Scholar

Ho, A M, Ling, E. Systemic air embolism after lung trauma. Anesthesiology. 1999; 90(2):564–75.Google Scholar

de Blauw, M H. An unusual complication of a central venous catheter placement. Neth J Med. 2012; 70(1):40–4.Google Scholar

Kuwahara, T, Takahashi, A, Takahashi, Y, et al. Clinical characteristics of massive air embolism complicating left atrial ablation of atrial fibrillation: Lessons from five cases. Europace. 2012; 14(2):204–8.Google Scholar

Fitchet, A, Fitzpatrick, A P. Central venous air embolism causing pulmonary oedema mimicking left ventricular failure. BMJ. 1998; 316(7131):604–6.Google Scholar

Valentino, R, Hilbert, G, Vargas, F, Gruson, D. Computed tomographic scan of massive cerebral air embolism. Lancet. 2003; 361(9372):1848.Google Scholar

Herber, N, Salvolin, L, Salvolini, U. Changes in CT evidence of massive cerebral air embolism. Eur J Radiol Extra. 2004; 51:9–10.Google Scholar

Suzuki, T, Ando, T, Usami, A, et al. Cerebral air embolism as a complication of peptic ulcer in the gastric tube: case report. BMC Gastroenterol. 2011; 11:139–41.Google Scholar

Griese, H, Seifert, D, Koerfer, R. Cortical infarction following cardiosurgical procedures: Air embolism as a probable cause. Eur Neurol. 2009; 61(6):343–9.Google Scholar

Gao, G K, Wu, D, Yang, Y, et al. Cerebral magnetic resonance imaging of compressed air divers in diving accidents. Undersea Hyperb Med. 2009; 36(1):33–41.Google Scholar

Rodriguez, R A, Rubens, F D, Wozny, D, Nathan, H J Cerebral emboli detected by transcranial Doppler during cardiopulmonary bypass are not correlated with postoperative cognitive deficits. Stroke. 2010; 41(10):2229–35.Google Scholar

Furuya, H, Okumura, F. Detection of paradoxical air embolism by transesophageal echocardiography. Anesthesiology. 1984; 60(4):374–7.Google Scholar

Romero, J R, Frey, J L, Schwamm, L H, et al. Cerebral ischemic events associated with ‘bubble study’ for identification of right to left shunts. Stroke. 2009; 40(7):2343–8.Google Scholar

Tsivgoulis, G, Stamboulis, E, Sharma, V K, et al. Safety of transcranial Doppler ‘bubble study’ for identification of right to left shunts: An international multicentre study. J Neurol Neurosurg Psychiatry. 2011; 82(11):1206–8.Google Scholar

Orebaugh, S L. Venous air embolism: Clinical and experimental considerations. Crit Care Med. 1992; 20(8):1169–77.Google Scholar

Mehlhorn, U, Burke, E J, Butler, B D, et al. Body position does not affect the hemodynamic response to venous air embolism in dogs. Anesth Analg. 1994; 79(4):734–9.Google Scholar

Bowdle, T A, Artru, A A. Treatment of air embolism with a special pulmonary artery catheter introducer sheath in sitting dogs. Anesthesiology. 1988; 68(1):107–10.Google Scholar

Bedford, R F, Marshall, W K, Butler, A, Welsh, J E. Cardiac catheters for diagnosis and treatment of venous air embolism: A prospective study in man. J Neurosurg. 1981; 55(4):610–14.Google Scholar

Kol, S, Ammar, R, Weisz, G, Melamed, Y. Hyperbaric oxygenation for arterial air embolism during cardiopulmonary bypass. Ann Thorac Surg. 1993; 55(2):401–3.Google Scholar

Sahni, T, Jain, M. Hyperbaric oxygen therapy: Research indications and emerging role in neurological illnesses. Apollo Med. 2005; 2(1):16–20.Google Scholar

Mortensen, C R. Hyperbaric oxygen therapy. Curr Anaesth Crit Care. 2008; 19:333–7.Google Scholar

Murphy, B P, Harford, F J, Cramer, F S. Cerebral air embolism resulting from invasive medical procedures. Treatment with hyperbaric oxygen. Ann Surg. 1985; 201(2):242–5.Google Scholar

Newcomb, A, Frawley, G, Fock, A, Bennett, M, d’Udekem, Y. Hyperbaric oxygenation in the management of cerebral arterial gas embolism during cavopulmonary connection surgery. J Cardiothorac Vasc Anesth. 2008; 22(4):576–80.Google Scholar

Blanc, P, Boussuges, A, Henriette, K, Sainty, J M, Deleflie, M. Iatrogenic cerebral air embolism: Importance of an early hyperbaric oxygenation. Intensive Care Med. 2002; 28(5):559–63.Google Scholar

Dutka, A J, Mink, R, McDermott, J, Clark, J B, Hallenbeck, J M. Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism. Stroke. 1992; 23(10):1515–20.Google Scholar

McDermott, J J, Dutka, A J, Evans, D E, Flynn, E T. Treatment of experimental cerebral air embolism with lidocaine and hyperbaric oxygen. Undersea Biomed Res. 1990; 17(6):525–34.Google Scholar

Mitchell, S J, Merry, A F, Frampton, C, et al. Cerebral protection by lidocaine during cardiac operations: A follow-up study. Ann Thorac Surg. 2009; 87(3):820–5.Google Scholar

Ballham, A, Allen, M J. Air embolism in a sports diver. Br J Sports Med. 1983; 17(1):7–9.Google Scholar

Dutka, A J, Mink, R B, Pearson, R R, Hallenbeck, J M. Effects of treatment with dexamethasone on recovery from experimental cerebral arterial gas embolism. Undersea Biomed Res. 1992; 19(2):131–41.Google Scholar

Ryu, K H, Hindman, B J, Reasoner, D K, Dexter, F. Heparin reduces neurological impairment after cerebral arterial air embolism in the rabbit. Stroke. 1996; 27(2):303–9.Google Scholar

Vane, J R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971; 231:232–5.Google Scholar

Evangelista, V, Manarini, S, Di Santo, A, et al. De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin. Circ Res. 1998; 593–5.Google Scholar

Bjornsson, T D, Schneider, D E, Berger, H. Aspirin aetylates fibrinogen and enhances fibrinolysis. Fibrinolytic effect is independent of changes in plasminogen activator levels. J Pharmacol Exp Ther. 1989; 250:154–61.Google Scholar

De Schryver, E L L M, van Gijn, J, Kappelle, L J, Koudstaal, P J, Algra, A. Non-adherence to aspirin or oral anticoagulants in secondary prevention after ischaemic stroke. J Neurol. 2005;252:1316–21.Google Scholar

Kovich, O, Clark, C O. Thrombotic complications related to discontinuation of warfarin and aspirin therapy perioperatively for cutaneous operation. J Am Acad Dermatol. 2003; 48:233–7.Google Scholar

Sibon, I, Orgogozo, J-M. Antiplatelet drug discontinuation is a risk factor for ischemic stroke. Neurology. 2004; 62:1187–9.Google Scholar

Maulaz, A B, Bezerra, D C, Michel, P, Bogousslavsky, J. Effect of discontinuing aspirin therapy on the risk of brain ischemic stroke. Arch Neurol. 2005; 62:1217–20.Google Scholar

Broderick, J P, Bonomo, J B, Kissela, B M, et al. Withdrawal of antithrombotic agents and its impact on ischemic stroke occurrence. Stroke. 2011; 42:2509–14.Google Scholar

Watanabe, H, Morimoto, T, Natsuaki, M, et al. Antiplatelet therapy discontinuation and the risk of serious cardiovascular events after coronary stenting: Observations from the CREDO-Kyoto Registry Cohort-2. PLoS One. 2015; 10(4):e0124314.Google Scholar

Rossini, R, Musumeci, G, Capodanno, D, et al. Perioperative management of oral antiplatelet therapy and clinical outcomes in coronary stent patients undergoing surgery. Results of a multicentre registry. Thromb Haemost. 2015; 113(2):272–82.Google Scholar

Burger, W, Chemnitius, J M, Kneissl, G D, Rücker, G. Low-dose aspirin for secondary cardiovascular prevention – cardiovascular risks ater its perioperative withdrawal versus bleed risks with its continuation – review and meta-analysis. J Int Med. 2005; 257:399–414.Google Scholar

García Rodríguez, L A, Soriano, L C, Hill, C, Johansson, S. Increased risk of stroke after discontinuation of acetylsalicylic acid: a UK primary care study. Neurology. 2011; 76:740–6.Google Scholar

Weimar, C, Cotton, D, Sha, N, et al. Discontinuation of antiplatelet study medication and risk of recurrent stroke and cardiovascular events: results from the PRoFESS study. Cerebrovasc Dis. 2013; 35:538–43.Google Scholar

Lee, J, Kim, J K, Kim, J H, et al. Recovery time of platelet function after aspirin withdrawal. Curr Ther Res Clin Exp. 2014; 76:26–31.Google Scholar

Le Manach, Y, Kahn, D, Bachelot-Loza, C, et al. Impact of aspirin and clopidogrel interruption on platelet function in patients undergoing major vascular surgery. PLoS One. 2014; 9(8):e104491.Google Scholar

Aguejouf, O, Belougne-Malfatti, E, Doutremepuich, F, Belon, P, Doutremepuich, C. Thromboembolic complications several days after a single-dose administration of aspirin. Thromb Res. 1998; 89(3):123–7.Google Scholar

Doutremepuich, C, Aguejouf, O, Eizayaga, F X, Desplat, V. Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition? Pathophysiol Haemost Thromb. 2007; 36:40–4.Google Scholar

Aguejouf, O, Eizayaga, F, Desplat, V, Belon, P, Doutremepuich, C. Prothrombotic and hemorrhagic effects of aspirin. Clin Appl Thromb Hemost. 2009; 15(5):523–8.Google Scholar

Vial, J H, McLeod, L J, Roberts, M S. Rebound elevation in urinary thromboxane B2 and 6-keto-PGF1 alpha excretion after aspirin withdrawal. Adv Prostatglandin Thromboxane Leukot Res. 1991; 21:157–60.Google Scholar

Moussa, S A, Forsythe, M S, Bozarth, J M, Reilly, T M. Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1. Cardiology. 1993; 83:367–73.Google Scholar

Armstrong, M J, Gronseth, G, Anderson, D C, et al. Summary of evidence-based guideline: Periprocedural management of antithrombotic medications in patients with ischemic cerebrovascular disease: Report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2013; 80:2065–9.Google Scholar

Mantz, J, Samama, C M, Tubach, F, et al. Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: The multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial. Br J Anaesth. 2011; 107(6):899–910.Google Scholar

Dorsam, R T, Kunapuli, S P. Central role of the P2Y12 receptor in platelet activation. J Clin Invest. 2004; 113(3):340–5.Google Scholar

CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996; 348(9038):1329–39.Google Scholar

Diehl, P, Halscheid, C, Olivier, C, et al. Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation. Clin Res Cardiol. 2011; 100:765–71.Google Scholar

Sambu, N, Warner, T, Curzen, N. Clopidogrel withdrawal: is there a “rebound” phenomenon? Thromb Haemost. 2011; 105:211–20.Google Scholar

Collet, J-P, Montalescot, G, Steg, P G, et al. Clinical outcomes according to permanent discontinuation of clopidogrel or placebo in the CHARISMA trial. Arch Cardiovasc Dis. 2009; 102:485–96.Google Scholar

Geraghty, O C, Paul, N L M, Chandratheva, A, Rothwell, P M. Low risk of rebound events after a short course of clopidogrel in acute TIA or minor stroke. Neurology. 2010; 74:1891–6.Google Scholar

Ford, I, Scott, N W, Herd, V, et al. A randomized controlled trial of platelet activity before and after cessation of clopidogrel therapy in patients with stable cardiovascular disease. J Am Coll Cardiol. 2014; 63:233–9.Google Scholar

Rossen, J D, Chalouhi, N, Wassef, S N, et al. Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques. J Neurosurg. 2012; 117:929–33.Google Scholar

Fiedler, A K, Mehilli, J, Kufner, S, et al. Randomised, double-blind trial on the value of tapered discontinuation of clopidogrel maintenance therapy after drug-eluting stent implantation. Thromb Haemost. 2014; 111:1041–9.Google Scholar

Mauri, L, Kereiakes, D J, Yeh, R W, et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014;Nov 16 (Epub ahead of print).Google Scholar

Vongpatanasin, W, Hillis, L D, Lange, R A. Prosthetic heart valves. N Engl J Med. 1996; 335:407–16.Google Scholar

The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Guidelines for the management of atrial fibrillation. Eur Heart J. 2010; 31:2369–429.Google Scholar

Douketis, J D, Berger, P B, Dunn, A S, et al. The perioperative management of antithrombotic therapy. American College of Chest Physicians evidence-based clinicial practice guidelines (8th edition). Chest. 2008; 133:299–339S.Google Scholar

Di Biase, L, Burkhardt, J D, Santangeli, P, et al. Periprocedural stroke and bleeding complications in patients undergoing catheter ablation of atrial fibrillation with different anticoagulation management. Results from the role of coumadin in preventing thromboembolism in atrial fibrillation patients undergoing catheter ablation (COMPARE) randomized trial. Circulation. 2014; 129:2638–44.Google Scholar

Fang, M C, Go, A S, Chang, Y, Borowsky, L H, et al. Warfarin discontinuation after starting warfarin for atrial fibrillation. Circ Cardiovasc Qual Outcomes. 2010; 3:624–31.Google Scholar

Tulner, L R, Van Campen, J P C M, Kuper, I M J A, et al. Reasons for undertreatment with oral anticoagulants in frail geriatric outpatients with atrial fibrillation. A prospective, descriptive study. Drugs Aging. 2010; 27(1):39–50.Google Scholar

Blacker, D J, Wijdicks, E F M, McClelland, R L. Stroke risk in anticoagulated patients with atrial fibrillation. Neurology. 2003; 61:964–8.Google Scholar

Raunsø, J, Selmer, C, Olesen, J B, et al. Increased short-term riks of thrombo-embolism or death after interruption of warfarin treatment in patients with atrial fibrillation. Eur Heart J. 2012; 33(15):1886–92.Google Scholar

Di Biase, L, Gaita, F, Toso, E, et al. Does periprocedural anticoagulation management of atrial fibrillation affect the prevalence of silent thromboembolic lesion detected by diffusion cerebral magnetic resonance imaging in patients undergoing radiofrequency atrial fibrillation ablation with open irrigated catheters? Results from a prospective multicenter study. Heart Rhythm. 2014; 11(5):791–8.Google Scholar

Garcia, D A, Regan, S, Henault, L E, et al. Risk of thromboembolism with short-term interruption of warfarin therapy. Arch Intern Med. 2008; 168(1):63–9.Google Scholar

Cundiff, D K. Clinical evidence for rebound hypercoagulability after discontinuing oral anticoagulants for venous thromboembolism. Medscape J Med. 2008; 10(11):258.Google Scholar

Genewein, U, Haeberli, A, Straub, P W, Beer, J H. Rebound after cessation of oral anticoagulant therapy: The biochemical evidence. Br J Haematol. 1996;92:479–85.Google Scholar

Reddy, V Y, Sievert, H, Halperin, J, et al. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: A randomized clinical trial. JAMA. 2014; 312(19):1988–98.Google Scholar

Bai, R, Horton, R P, Di Biase, L, et al. Intraprocedural and long-term incomplete occlusion of the left atrial appendage following placement of the Watchman device: A single center experience. J Cardiovasc Electrophysiol. 2012; 23(5):455–61.Google Scholar

Chatterjee, S, Sardar, P, Giri, J S, Ghosh, J, Mukherjee, D. Treatment discontinuations with new oral agents for long-term anticoagulation: Insights from a meta-analysis of 18 randomized trials including 101,801 patients. Mayo Clin Proc. 2014; 89(7):896–907.Google Scholar

Zalesak, M, Siu, K, Francis, K, et al. Higher persistence in newly diagnosed nonvalvular atrial fibrillation patients treated with dabigatran versus warfarin. Circ Cardiovasc Qual Outcomes. 2013; 6(5):567–74.Google Scholar

Nascimento, T, Birnie, D H, Healey, J S, et al. Managing novel oral anticoagulants in patients with atrial fibrillation undergoing device surgery: Canadian survey. Can J Cardiol. 2014; 30(2):231–6.Google Scholar

Watanabe, M, Siddiqui, F M, Qureshi, A I. Incidence and management of ischemic stroke and intracerebral hemorrhage in patients on dabigatran etexilate treatment. Neurocrit Care. 2012; 16:203–9.Google Scholar

Patel, M R, Hellkamp, A S, Lokhnygina, Y, et al. Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: Analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). J Am Coll Cardiol. 2013; 61(6):651–8.Google Scholar

Reynolds, M R. Discontinuation of rivaroxaban: Filling in the gaps. J Am Coll Cardiol. 2013;61(6):659–60.Google Scholar

Granger, C B, Alexander, J H, McMurray, J J, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011; 365(11):981–92.Google Scholar

Granger, C B, Lopes, R D, Hanna, M, et al. Clinical events after transitioning from apixaban versus warfarin to warfarin at the end of the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial. Am Heart J. 2015; 169(1):25–30.Google Scholar

Connolly, S J, Ezekowitz, M D, Yusuf, S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009; 361(12):1139–51.Google Scholar

Giugliano, R P, Ruff, C T, Braunwald, E, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013; 369(22):2093–104.Google Scholar

Davignon, J, Leiter, L A. Ongoing clinical trials of the pleiotropic effects of statins. Vasc Health Risk Manag. 2005; 1(1):29–40.Google Scholar

Amarenco, P, Bogousslavsky, J, Callahan, A, et al. High-dose atorvastatin after stroke or transient ischemic attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) investigators. N Eng J Med. 2006; 355:549–59.Google Scholar

Colvicchi, F, Bassi, A Santini, M, Caltagirone, C. Discontinuation of statin therapy and clinical outcome after ischemic stroke. Stroke. 2007; 38:2652–7.Google Scholar

Blanco, M, Nombela, F, Castellanos, M, et al. Statin treatment withdrawal in ischemic stroke: a controlled randomized study. Neurology. 2007; 69:904–10.Google Scholar

Fuentes, B, Martínez-Sánchez, P, Díez-Tejedor, E. Lipid-lowering drugs in ischemic stroke prevention and their influence on acute stroke outcome. Cerebrovasc Dis. 2009; 27(1):126–33.Google Scholar

Endres, M. Statins and stroke. J Cereb Blood Flow Metab. 2005; 25(9):1093–110.Google Scholar

Li, J-J, Li, Y-S, Chu, J-M, et al. Changes of plasma inflammatory markers after withdrawal of statin therapy in patients with hyperlipidemia. Clinica Chimica Acta. 2006; 366:269–73.Google Scholar

Rosengarten, B, Auch, D, Kaps, M. Effects of initiation and acute withdrawal of statins on the neurovascular coupling mechanism in healthy, normocholesterolemic humans. Stroke. 2007; 38:3193–7.Google Scholar

Dowlatshahi, D, Demchuk, A M, Fang, J, et al. Association of statins and statin discontinuation with poor outcome and survival after intracerebral hemorrhage. Stroke. 2012; 43:1518–23.Google Scholar

Robinson, T G, Potter, J F, Ford, G A, et al. Effects of antihypertensive treatment after acute stroke in the Continue or Stop Post-Stroke Antihypertensives Collaborative Study (COSSACS): A prospective, randomised, open, blinded-endpoint trial. Lancet Neurol. 2010; 9(8):767–75.Google Scholar

Bath, et al. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): A partial-factorial randomised controlled trial. Lancet. 2014; 22 October: Epub ahead of print.Google Scholar

Baird, T A, Parsons, M W, Phan, T, et al. Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke. 2003; 34:2208–14.Google Scholar

Rosso, C, Corvol, J C, Pires, C, et al. Intensive versus subcutaneous insulin in patients with hyperacute stroke: Results from the randomized INSULINFARCT trial. Stroke. 2012; 43(9):2343–9.Google Scholar