Appendix II - The mammalian Y chromosome
from Introduction
Published online by Cambridge University Press: 06 August 2010
Summary
The mammalian Y chromosome, which had received little detailed attention previously, became the focus of vigorous research activity during the 1980s: Goodfellow et al. (1985) reviewed the Y chromsome, and Davies et al. (1987) presented the report of the Committee on the Genetic Constitution of the X and Y Chromosomes to the Ninth Human Gene Mapping Conference. Various forms of maps have been published (Vergnaud et al. 1986; Ferguson-Smith et al. 1987). The chromsome has merited a monograph (Sandberg 1985) and has become the subject of intense study (Goodfellow et al. 1987). However, few genes are known to be Y-linked in man, and there is little published information on the Y chromosome of other mammals, aside from the mouse. The existing data are presented below. An asterisk indicates that a probably homologous gene or region is known in man (Davies et al. 1987; McKusick 1986).
Molecular studies of the mouse Y chromosome
Eicher et al. (1983) and Eicher and Washburn (1986) described cytogenetic and molecular studies that resulted in partitioning of the normal Y chromosome into 6 functionally distinct regions containing the centromere; the Tdy and Hya loci, and Bkm-related sequences; sequences involved with sperm motility and with Xmmv; an X-pairing-and-recombinant segment; Sts; and the telomere. Bishop et al. (1985) used a Y-specific genomic DNA probe (pY353/B) to examine the RFLPs in 10 newly established mouse lines of the European semispecies, Mus musculus domesticus and Mus musculus musculus, and identified 2 variant forms of the Y chromosome, each characteristic of 1 of the semispecies.
- Type
- Chapter
- Information
- X-Linked TraitsA Catalog of Loci in Non-human Mammals, pp. 29 - 40Publisher: Cambridge University PressPrint publication year: 1990