Book contents
- Brain Fables
- Brain Fables
- Copyright page
- Dedication
- Contents
- Preface 1 – The Question
- Preface 2 – Enter Patient
- Acknowledgements
- Special Thanks from Benjamin Stecher
- Chapter 1 The Shaky Six and the “Second Reality”
- Chapter 2 Pieces of a Puzzle?
- Chapter 3 Disease “Redefinition”: A Tough Pill to Swallow
- Chapter 4 Disease Subtypes: The Promise and the Fallacy
- Chapter 5 Protein Paradox
- Chapter 6 The Fault in Our Models
- Chapter 7 Biomarkers: The Promise and the Fallacy
- Chapter 8 Lessons from Oncology
- Chapter 9 Symptomatic vs. Disease-Modifying Therapies
- Chapter 10 The Hypothesis That Refuses to Die
- Chapter 11 Our Living Dissonance
- Chapter 12 The Scientific and Lay Narratives
- Chapter 13 Challenges Viewed from Afar
- Chapter 14 The Moonshot: Population-Based Studies of Aging
- Chapter 15 Predictions for the 2020s and Beyond
- Epilogue
- Note Added at Press Time – Reviving LOF
- References
- Index
Chapter 3 - Disease “Redefinition”: A Tough Pill to Swallow
Published online by Cambridge University Press: 29 June 2020
- Brain Fables
- Brain Fables
- Copyright page
- Dedication
- Contents
- Preface 1 – The Question
- Preface 2 – Enter Patient
- Acknowledgements
- Special Thanks from Benjamin Stecher
- Chapter 1 The Shaky Six and the “Second Reality”
- Chapter 2 Pieces of a Puzzle?
- Chapter 3 Disease “Redefinition”: A Tough Pill to Swallow
- Chapter 4 Disease Subtypes: The Promise and the Fallacy
- Chapter 5 Protein Paradox
- Chapter 6 The Fault in Our Models
- Chapter 7 Biomarkers: The Promise and the Fallacy
- Chapter 8 Lessons from Oncology
- Chapter 9 Symptomatic vs. Disease-Modifying Therapies
- Chapter 10 The Hypothesis That Refuses to Die
- Chapter 11 Our Living Dissonance
- Chapter 12 The Scientific and Lay Narratives
- Chapter 13 Challenges Viewed from Afar
- Chapter 14 The Moonshot: Population-Based Studies of Aging
- Chapter 15 Predictions for the 2020s and Beyond
- Epilogue
- Note Added at Press Time – Reviving LOF
- References
- Index
Summary
The year was 2015. Members of the Movement Disorders Society were abuzz with interest over the publication of a new set of criteria for the diagnosis of Parkinson’s disease. Discussions around the world centered on how to put the changes in perspective. How different were the new criteria compared to the one we had relied on for most of the prior two decades? How would it impact research? Could it be useful in sending us down a new path that might finally culminate in disease-modifying therapies?
- Type
- Chapter
- Information
- Brain FablesThe Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them, pp. 25 - 32Publisher: Cambridge University PressPrint publication year: 2020