Molecular Chaperones and Cell Signalling

doi:10.1017/CBO9780511546310

This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

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Contents

Frontmatter
pp i-iv
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Contents
pp v-viii
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Contributors
pp ix-xii
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Preface
pp xiii-xiv
- By Brian Henderson, Professor of Cell Biology, Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology, University of Sheffield Medical School; Head of the Immunobiology Research Unit
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SECTION 1 - MOLECULAR CHAPERONES AND THE CELL STRESS RESPONSE
pp 1-2
- By Brian Henderson, Professor of Cell Biology Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology University of Sheffield Medical School; Head of the Immunobiology Research Unit
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1 - Chaperone Function: The Orthodox View
pp 3-21
- By R. John Ellis, Department of Biological Sciences, University of Warwick, United Kingdom
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2 - Intracellular Disposition of Mitochondrial Molecular Chaperones: Hsp60, mHsp70, Cpn10 and TRAP-1
pp 22-42
- By Radhey S. Gupta, Department of Biochemistry, McMaster University, Hamilton, Canada, Timothy Bowes, Department of Biochemistry, McMaster University, Hamilton, Canada, Skanda Sadacharan, Department of Biochemistry, McMaster University, Hamilton, Canada, Bhag Singh, Department of Biochemistry, McMaster University, Hamilton, Canada
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SECTION 2 - CHANGING PARADIGMS OF PROTEIN TRAFFICKING AND PROTEIN FUNCTION
pp 43-44
- By Brian Henderson, Professor of Cell Biology Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology University of Sheffield Medical School; Head of the Immunobiology Research Unit
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3 - Novel Pathways of Protein Secretion
pp 45-60
- By Giovanna Chimini, Centre d'Immunology de Marseille-Luminy, INSERM/CNRS et Université de la Mediterranée, France, Anna Rubartelli, Department of Oncogenesis, National Cancer Research Institute, Genova Italy
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4 - Moonlighting Proteins: Proteins with Multiple Functions
pp 61-77
- By Constance J. Jeffery, University of Illinois at Chicago, Department of Biological Sciences, Chicago, Illinois
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5 - Molecular Chaperones: The Unorthodox View
pp 78-96
- By Brian Henderson, Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom, Alireza Shamaei-Tousi, Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom
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SECTION 3 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: MOLECULAR CHAPERONES AS CELL REGULATORS
pp 97-98
- By Brian Henderson, Professor of Cell Biology Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology University of Sheffield Medical School; Head of the Immunobiology Research Unit
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6 - Cell-Cell Signalling Properties of Chaperonins
pp 99-112
- By Anthony Coates, Department of Medical Microbiology, St. George's Hospital Medical School, London, United Kingdom, Peter Tormay, Department of Medical Microbiology, St. George's Hospital Medical School, London, United Kingdom
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7 - Toll-Like Receptor-Dependent Activation of Antigen Presenting Cells by Hsp60, gp96 and Hsp70
pp 113-132
- By Ramunas M. Vabulas, Max-Planck-Institut für Biochemie, Martinsried, Germany, Hermann Wagner, Institut für Med. Mikrobiologie, Immunologie u. Hygiene, Technische Universität München, München, Germany
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8 - Regulation of Signal Transduction by Intracellular and Extracellular Hsp70
pp 133-143
- By Alexzander Asea, Center for Molecular Stress Response, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, U.S.A., Stuart K. Calderwood, Department of Radiation Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, U.S.A.
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9 - Hsp72 and Cell Signalling
pp 144-159
- By Vladimir L. Gabai, Department of Biochemistry, Boston University School of Medicine, Boston, Massachussets, U.S.A., Michael Y. Sherman, Department of Biochemistry, Boston University School of Medicine, Boston, Massachussets, U.S.A.
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10 - Heat Shock Proteins, Their Cell Surface Receptors and Effect on the Immune System
pp 160-178
- By Thomas Lehner, Peter Gorer Department of Immunobiology, Guy's, King's and St. Thomas Hospital Medical School London, United Kingdom, Yufei Wang, Peter Gorer Department of Immunobiology, Guy's, King's and St. Thomas' Hospital Medical School, London, United Kingdom, Trevor Whittall, Peter Gorer Department of Immunobiology, Guy's, King's and St. Thomas' Hospital Medical School, London, United Kingdom, Lesley A. Bergmeier, Peter Gorer Department of Immunobiology, Guy's, King's and St. Thomas Hospital Medical School, London, United Kingdom
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11 - Molecular Chaperone–Cytokine Interactions at the Transcriptional Level
pp 179-192
- By Anastasis Stephanou, Medical Molecular Biology Unit, Institute of Child Health, University College London, London, United Kingdom, David S. Latchman, The Master, Birkbeck College, University of London, London, United Kingdom
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SECTION 4 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL SIGNALS
pp 193-194
- By Brian Henderson, Professor of Cell Biology Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology University of Sheffield Medical School; Head of the Immunobiology Research Unit
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12 - Heat Shock Protein Release and Naturally Occurring Exogenous Heat Shock Proteins
pp 195-219
- By Johan Frostegård, Unit of Rheumatology, Department of Medicine and Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden, A. Graham Pockley, Immunobiology Research Unit, Division of Clinical Sciences (North), (University of Sheffield), Northern General Hospital, Sheffield, United Kingdom
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13 - Hsp27 as an Anti-inflammatory Protein
pp 220-233
- By Krzysztof Laudanski, Immunobiology & Stress Response Laboratories, University of Rochester Medical Center, Department of Surgery, Rochester, New York, U.S.A., Asit K. De, Immunobiology & Stress Response Laboratories, University of Rochester Medical Center, Department of Surgery, Rochester, New York, U.S.A., Carol L. Miller-Graziano, Immunobiology & Stress Response Laboratories, University of Rochester Medical Center, Department of Surgery, Rochester, New York, U.S.A.
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14 - BiP, a Negative Regulator Involved in Rheumatoid Arthritis
pp 234-248
- By Valerie M. Corrigall, Academic Department of Rheumatology, GKT School of Medicine, King's College London, London, United Kingdom, Gabriel S. Panayi, Academic Department of Rheumatology, Guy's, King's and St. Thomas' School of Medicine, King's College London, London, United Kingdom
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SECTION 5 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: MOLECULAR CHAPERONES AS THERAPEUTICS
pp 249-250
- By Brian Henderson, Professor of Cell Biology Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology University of Sheffield Medical School; Head of the Immunobiology Research Unit
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15 - Neuroendocrine Aspects of the Molecular Chaperones ADNF and ADNP
pp 251-262
- By Illana Gozes, Department of Clinical Biochemistry and Interdepartmental Core Facility, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Inna Vulih, Department of Clinical Biochemistry and Interdepartmental Core Facility, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Irit Spivak-Pohis, Department of Clinical Biochemistry and Interdepartmental Core Facility, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Sharon Furman, Department of Clinical Biochemistry and Interdepartmental Core Facility, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
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16 - Heat Shock Proteins Regulate Inflammation by Both Molecular and Network Cross-Reactivity
pp 263-287
- By Francisco J. Quintana, Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel, Irun R. Cohen, Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
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17 - Heat Shock Protein Fusions: A Platform for the Induction of Antigen-Specific Immunity
pp 288-299
- By Lee Mizzen, Stressgen Biotechnologies Corporation, British Columbia, Canada, John Neefe, Stressgen Biotechnologies Inc., Collegeville, Pennsylvania, U.S.A.
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18 - Molecular Chaperones as Inducers of Tumour Immunity
pp 300-318
- By Pinaki P. Banerjee, Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, Connecticut, U.S.A., Zihai Li, Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, Connecticut, U.S.A.
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SECTION 6 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: WHAT DOES THE FUTURE HOLD?
pp 319-320
- By Brian Henderson, Professor of Cell Biology Eastman Dental Institute, University College London; Head of the Cellular Microbiology Research Group, A. Graham Pockley, Professor of Immunobiology University of Sheffield Medical School; Head of the Immunobiology Research Unit
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19 - Gazing into the Crystal Ball: The Unfolding Future of Molecular Chaperones
pp 321-326
- By Lawrence E. Hightower, Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut, U.S.A.
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Index
pp 327-330
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Molecular Chaperones and Cell Signalling

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Contents

Frontmatter
pp i-iv

Contents
pp v-viii

Contributors
pp ix-xii

Preface
pp xiii-xiv

SECTION 1 - MOLECULAR CHAPERONES AND THE CELL STRESS RESPONSE
pp 1-2

1 - Chaperone Function: The Orthodox View
pp 3-21

2 - Intracellular Disposition of Mitochondrial Molecular Chaperones: Hsp60, mHsp70, Cpn10 and TRAP-1
pp 22-42

SECTION 2 - CHANGING PARADIGMS OF PROTEIN TRAFFICKING AND PROTEIN FUNCTION
pp 43-44

3 - Novel Pathways of Protein Secretion
pp 45-60

4 - Moonlighting Proteins: Proteins with Multiple Functions
pp 61-77

5 - Molecular Chaperones: The Unorthodox View
pp 78-96

SECTION 3 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: MOLECULAR CHAPERONES AS CELL REGULATORS
pp 97-98

6 - Cell-Cell Signalling Properties of Chaperonins
pp 99-112

7 - Toll-Like Receptor-Dependent Activation of Antigen Presenting Cells by Hsp60, gp96 and Hsp70
pp 113-132

8 - Regulation of Signal Transduction by Intracellular and Extracellular Hsp70
pp 133-143

9 - Hsp72 and Cell Signalling
pp 144-159

10 - Heat Shock Proteins, Their Cell Surface Receptors and Effect on the Immune System
pp 160-178

11 - Molecular Chaperone–Cytokine Interactions at the Transcriptional Level
pp 179-192

SECTION 4 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL SIGNALS
pp 193-194

12 - Heat Shock Protein Release and Naturally Occurring Exogenous Heat Shock Proteins
pp 195-219

13 - Hsp27 as an Anti-inflammatory Protein
pp 220-233

14 - BiP, a Negative Regulator Involved in Rheumatoid Arthritis
pp 234-248

SECTION 5 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: MOLECULAR CHAPERONES AS THERAPEUTICS
pp 249-250

15 - Neuroendocrine Aspects of the Molecular Chaperones ADNF and ADNP
pp 251-262

16 - Heat Shock Proteins Regulate Inflammation by Both Molecular and Network Cross-Reactivity
pp 263-287

17 - Heat Shock Protein Fusions: A Platform for the Induction of Antigen-Specific Immunity
pp 288-299

18 - Molecular Chaperones as Inducers of Tumour Immunity
pp 300-318

SECTION 6 - EXTRACELLULAR BIOLOGY OF MOLECULAR CHAPERONES: WHAT DOES THE FUTURE HOLD?
pp 319-320

19 - Gazing into the Crystal Ball: The Unfolding Future of Molecular Chaperones
pp 321-326

Index
pp 327-330

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Molecular Chaperones and Cell Signalling

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