Ackerman, M. J. 1998 The Visible Human Project: a resource for anatomical visualizationStud. Health Technol. Inform. 52 1030
Adams, M. F.Bayraktar, H. H.Keaveny, T. M.Papadopoulos, P. 2004 Ultrascalable implicit finite element analyses in solid mechanics with over a half a billion degrees of freedomProceedings of the 2004 ACM/IEEE Conference on Supercomputing
Albracht, K.Arampatzis, A.Baltzopoulos, V. 2008 Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivoJ. Biomech. 41 2211
An, K. N.Takahashi, K.Harrigan, T. P.Chao, E. Y. 1984 Determination of muscle orientations and moment armsJ. Biomech. Eng., 106 280
Andersen, T. L.Sondergaard, T. E.Skorzynska, K. E. 2009 A physical mechanism for coupling bone resorption and formation in adult human boneAm. J. Pathol., 174 239
Andersen, T. L.Soe, K.Sondergaard, T. E.Plesner, T.Delaisse, J. M. 2010 Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cellsBr. J. Haematol 148 551
Ardizzoni, A. 2001 Osteocyte lacunar size – lamellar thickness relationships in human secondary osteonsBone 28 215
Aristotle, 1045
Ascher, U. M.Petzold, L. R. 1998 Computer Methods for Ordinary Differential Equations and Differential-Algebraic EquationsSIAM
Baca, V.Horak, Z.Mikulenka, P.Dzupa, V. 2008 Comparison of an inhomogeneous orthotropic and isotropic material models used for FE analysesMed. Eng. Phys 30 924
Bassingthwaighte, J. B. 2000 Strategies for the physiome projectAnn. Biomed. Eng. 28 1043
Bassingthwaighte, J.Hunter, P.Noble, D. 2009 The Cardiac Physiome: perspectives for the futureExp. Physiol 94 597
Bathe, K. J.Wilson, E. L. 1976 Numerical Methods in Finite Element AnalysisPrentice-Hall
Behari, J. 2009 Biophysical Bone Behavior: Principles and ApplicationsJohn Wiley & Sons
Bekas, C.Curioni, A.Arbenz, P. 2008 Extreme scalability challenges in micro-finite element simulations of human boneInternational Supercomputing ConferenceISC
Benameur, S.Mignotte, M.Labelle, H.Guise, J. A. 2005 A hierarchical statistical modeling approach for the unsupervised 3-D biplanar reconstruction of the scoliotic spineIEEE Trans. Biomed. Eng 52 2041
Bensamoun, S. F.Ringleb, S. I.Chen, Q. 2007 Thigh muscle stiffness assessed with magnetic resonance elastography in hyperthyroid patients before and after medical treatmentJ. Magn. Reson. Imaging 26 708
Beraudi, A.Stea, S.Bordini, B.Baleani, M.Viceconti, M. 2010 Osteon classification in human fibular shaft by circularly polarized lightCells Tissues Organs 191 260
Bergmann, G.Deuretzbacher, G.Heller, M. 2001 Hip contact forces and gait patterns from routine activitiesJ. Biomech 34 859
Bernstein, N. 1967 The Co-ordination and Regulation of MovementsPergamon Press
Bevill, G.Farhamand, F.Keaveny, T. M. 2009 Heterogeneity of yield strain in low-density versus high-density human trabecular boneJ. Biomech. 42 2165
Bikle, D. D.Sakata, T.Halloran, B. P. 2003 The impact of skeletal unloading on bone formationGravit. Space Biol. Bull. 16 45
Bilezikian, J. P.Raisz, L. G.Martin, T. J. 2008 Principles of Bone BiologyAcademic Press
Blemker, S. S.Pinsky, P. M.Delp, S. L. 2005 A 3D model of muscle reveals the causes of nonuniform strains in the biceps brachiiJ. Biomech. 38 657
Boutroy, S.Bouxsein, M. L.Munoz, F.Delmas, P. D. 2005 In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomographyJ. Clin. Endocrinol. Metab. 90 6508
Brower, A. C.Allman, R. M. 1981 Pathogenesis of the neurotrophic joint: neurotraumatic vs. neurovascularRadiology 139 349
Brown, T. D.Ferguson, A. B. 1980 Mechanical property distributions in the cancellous bone of the human proximal femurActa Orthop. Scand. 51 429
Buchanan, T. S.Lloyd, D. G.Manal, K.Besier, T. F. 2004 Neuromusculoskeletal modeling: estimation of muscle forces and joint moments and movements from measurements of neural commandJ. Appl. Biomech. 20 367
Burr, D. B.Robling, A. G.Turner, C. H. 2002 Effects of biomechanical stress on bones in animalsBone 30 781
Calvo, B.Ramirez, A.Alonso, A. 2010 Passive nonlinear elastic behaviour of skeletal muscle: experimental results and model formulationJ. Biomech. 43 318
Campanacci, M. 1999 Bone and Soft Tissue Tumors: Clinical Features, Imaging, Pathology and TreatmentSpringer Verlag
Campbell, D. T. ( 1974 Studies in the Philosophy of Biology and Related ProblemsAyala, P. J.Dobzhansky, T.University of California Press
Cappozzo, A.Croce, U.Leardini, A.Chiari, L. 2005 Human movement analysis using stereophotogrammetry. Part 1: theoretical backgroundGait Posture 21 186
Carins, J. 2005 http://dspace.dsto.defence.gov.au/dspace/handle/1947/4320
Carnap, R. 1958 Introduction to Symbolic Logic and Its ApplicationsDover Publications
Carter, D. R.Hayes, W. C. 1977 The compressive behavior of bone as a two-phase porous structureJ. Bone Joint Surg. Am. 59 954
Casas-Ganem, J.Healey, J. H. 2005 Advances that are changing the diagnosis and treatment of malignant bone tumorsCurr. Opin. Rheumatol. 17 79
Chaibi, Y.Cresson, T.Aubert, B. 2011 Fast 3D reconstruction of the lower limb using a parametric model and statistical inferences and clinical measurements calculation from biplanar X-raysComput. Methods Biomech. Biomed. Engin. 14
Chang, P. B.Williams, B. J.Bhalla, K S. 2001 Design and analysis of robust total joint replacements: finite element model experiments with environmental variablesJ. Biomech. Eng. 123 239
Chau, J. F.Leong, W. F.Li, B. 2009 Signaling pathways governing osteoblast proliferation, differentiation and functionHistol. Histopathol. 24 1593
Chenu, C.Marenzana, M. 2005 Sympathetic nervous system and bone remodelingJoint Bone Spine 72 481
Clancy, E. A.Morin, E. L.Merletti, R. 2002 Sampling, noise-reduction and amplitude estimation issues in surface electromyographyJ. Electromyogr. Kinesiol. 12 1
Clapworthy, G.Kohl, P.Gregerson, H. 2007 Digital Human ModelingSpringer-Verlag
Clapworthy, G.Viceconti, M.Coveney, P. V.Kohl, P. 2008 The virtual physiological human: building a framework for computational biomedicine I. EditorialPhilos. Transact. A Math. Phys. Eng. Sci. 366 2975
Collins, J. J. 1995 The redundant nature of locomotor optimization lawsJ. Biomech. 28 251
Confavreux, C. B.Levine, R. L.Karsenty, G. 2009 A paradigm of integrative physiology, the crosstalk between bone and energy metabolismsMol. Cell. Endocrinol. 310 21
Cook, R. D. 1995 Finite Element Modeling for Stress AnalysisJohn Wiley & Sons
Cooper, D. M.Turinsky, A. L.Sensen, C. W.Hallgrimsson, B. 2003 Quantitative 3D analysis of the canal network in cortical bone by micro-computed tomographyAnat. Rec. B New Anat. 274 169
Cowin, S. C. 1988 Bone MechanicsCRC
Cowin, S. C.Hegedus, D. H. 1976 Bone remodeling I: theory of adaptive elasticityJ. Elast. 6 313
Cristofolini, L. 1997 A critical analysis of stress shielding evaluation of hip prosthesesCrit. Rev. Biomed. Eng. 25 409
Cristofolini, L.Cappello, A.Toni, A. 1994 Experimental errors in the application of photoelastic coatings on human femurs with uncemented hip stemsStrain 30 95
Cristofolini, L.Taddei, F.Baleani, M. 2008 Multiscale investigation of the functional properties of the human femurPhilos. Transact. A Math. Phys. Eng. Sci. 366 3319
Damm, P.Graichen, F.Rohlmann, A.Bender, A.Bergmann, G. 2010 Total hip joint prosthesis for in vivo measurement of forces and momentsMed. Eng. Phys 32 95
Daumer, M.Thaler, K.Kruis, E. 2007 Steps towards a miniaturized, robust and autonomous measurement device for the long-term monitoring of patient activity: ActiBeltBiomed. Tech. (Berl.) 52 149
Dawkins, R. 1976 The Selfish GeneOxford University Press
Drillis, R.Contini, R.Bluestein, M. 1964 Body segment parameters; a survey of measurement techniquesArtif. Limbs 25 44
Durkin, J. L.Dowling, J. J. 2003 Analysis of body segment parameter differences between four human populations and the estimation errors of four popular mathematical modelsJ. Biomech. Eng. 125 515
Durkin, J. L.Dowling, J. J.Andrews, D. M. 2002 The measurement of body segment inertial parameters using dual energy X-ray absorptiometryJ. Biomech 35 1575
Edidin, A. A. 1991 Modelling the distribution of bone moduli in bone-implant systemsIthacaCornell University
Edman, K. A. 1979 The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibresJ. Physiol. 291 143
Eich-Soellner, E.Führer, C. 1998 Numerical Methods in Multibody DynamicsTeubner
Elefteriou, F. 2008 Regulation of bone remodeling by the central and peripheral nervous systemArch. Biochem. Biophys. 473 231
Eppell, S. J.Smith, B. N.Kahn, H.Ballarini, R. 2006 Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrilsJ. R. Soc. Interface 3 117
Erdemir, A.McLean, S.Herzog, W.van den Bogert, A. J. 2007 Model-based estimation of muscle forces exerted during movementsClin. Biomech. 22 131
Evans, F. G. 1957 Stress and Strain in Bones. Their Relation to Fractures and OsteogenesisCharles C. Thomas
Evans, F. G. 1973 Mechanical Properties of BoneCharles C. Thomas
Evans, F. G. 1973 Factors affecting the mechanical properties of boneBull. NY Acad. Med. 49 751
Farina, D.Merletti, R.Enoka, R. M. 2004 The extraction of neural strategies from the surface EMGJ. Appl. Physiol. 96 1486
Fenner, J. W.Brook, B.Clapworthy, G. 2008 The EuroPhysiome, STEP and a roadmap for the virtual physiological humanPhilos. Transact. A Math. Phys. Eng. Sci 366 2979
Fernandez, J. W.Buist, M. L.Nickerson, D. P.Hunter, P. J. 2005 Modelling the passive and nerve activated response of the rectus femoris muscle to a flexion loading: a finite element frameworkMed. Eng. Phys. 27 862
Fratzl-Zelman, N.Roschger, P.Misof, B. M. 2009 Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adultsBone 44 1043
Frigg, R.Hartmann, S. 2006 http://plato.stanford.edu/archives/fall2008/entries/models-science/
Frost, H. M. 1997 On our age-related bone loss: insights from a new paradigmJ. Bone. Miner. Res 12 1539
Fung, Y. C. 1993 Biomechanics: Mechanical Properties of Living TissuesSpringer
Fung, Y. C.Tong, P. 2001 Classical and Computational Solid MechanicsWorld Scientific
Ganss, B.Kim, R. H.Sodek, J. 1999 Bone sialoproteinCrit. Rev. Oral Biol. Med. 10 79
Gauthier, A.Kanis, J. AMartin, M. 2011 Development and validation of a disease model for postmenopausal osteoporosisOsteoporos. Int 22 771
Ghert, M.Colterjohn, N.Manfrini, M. 2007 The use of free vascularized fibular grafts in skeletal reconstruction for bone tumors in childrenJ. Am. Acad. Orthop. Surg. 15 577
Giangregorio, L.Blimkie, C. J. 2002 Skeletal adaptations to alterations in weight-bearing activity: a comparison of models of disuse osteoporosisSports Med. 32 459
Gilles, B.Magnenat-Thalmann, N. 2010 Musculoskeletal MRI segmentation using multi-resolution simplex meshes with medial representationsMed. Image Anal. 14 291
Glisson, R. R.Musgrave, D. S.Graham, R. D.Vail, T. P. 2000 Validity of photoelastic strain measurement on cadaveric proximal femoraJ. Biomech. Eng. 122 423
Gordon, A. M.Huxley, A. F.Julian, F. J. 1966 The variation in isometric tension with sarcomere length in vertebrate muscle fibresJ. Physiol. 184 170
Gordon, J. A.Tye, C. E.Sampaio, A. V. 2007 Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitroBone 41 462
Grassi, L.Hraiech, N.Schileo, E. 2010 Evaluation of the generality and accuracy of a new mesh morphing procedure for the human femurMed. Eng. Phys 33 112
Grätsch, T.Bathe, K. J. 2005 A posteriori error estimation techniques in practical finite element analysisComput. Struct. 83 235
Gray, H. 1918 Gray’s Anatomy: The Anatomical Basis of Medicine and SurgeryLongman
Harrigan, T. P.Jasty, M.Mann, R. W.Harris, W. H. 1988 Limitations of the continuum assumption in cancellous boneJ. Biomech. 21 269
Hauge, E. M.Qvesel, D.Eriksen, E. F.Mosekilde, L.Melsen, F. 2001 Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markersJ. Bone Miner. Res. 16 1575
Heinegard, D.Oldberg, A. 1989 Structure and biology of cartilage and bone matrix noncollagenous macromoleculesFASEB J. 3 2042
Helgason, B.Taddei, F.Palsson, H. 2008 A modified method for assigning material properties to FE models of bonesMed. Eng. Phys. 30 444
Homminga, J.Huiskes, R.Van Rietbergen, B.Ruegsegger, P.Weinans, H. 2001 Introduction and evaluation of a gray-value voxel conversion techniqueJ. Biomech. 34 513
Horowitz, A.Pollack, G. H. 1993 Force–length relation of isometric sarcomeres in fixed-end tetaniAm. J. Physiol. 264 C19
Hoyt, K.Kneezel, T.Castaneda, B.Parker, K. J. 2008 Quantitative sonoelastography for the in vivo assessment of skeletal muscle viscoelasticityPhys. Med. Biol. 53 4063
Hsiao, H.Guan, J.Weatherly, M. 2002 Accuracy and precision of two in-shoe pressure measurement systemsErgonomics 45 537
Hunter, G. K.Goldberg, H. A. 1993 Nucleation of hydroxyapatite by bone sialoproteinProc. Natl. Acad. Sci. USA 90 8562
Hunter, P. J.Viceconti, M. 2009 The VPH-Physiome project: standards and tools for multiscale modeling in clinical applicationsIEEE Rev. Biomed. Eng. 2 40
Hunter, P.Coveney, P. V.de Bono, B. 2010 A vision and strategy for the virtual physiological human in 2010 and beyondPhilos. Transact. A Math. Phys. Eng. Sci. 368 2595
Imai, K.Ohnishi, I.Bessho, M.Nakamura, K. 2006 Nonlinear finite element model predicts vertebral bone strength and fracture siteSpine 31 1789
Imai, Y.Youn, M. Y.Kondoh, S. 2009 Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclastsAnn. NY Acad. Sci. 1173 E31
Innocenti, M.Abed, Y. Y.Beltrami, G. 2009 Biological reconstruction after resection of bone tumors of the proximal tibia using allograft shell and intramedullary free vascularized fibular graft: long-term resultsMicrosurgery 29 361
Jedlicka, P. 2010 Ewing sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusionsInt. J. Clin. Exp. Pathol. 3 338
Jones, E. J.Bishop, P. A.Woods, A. K.Green, J. M. 2008 Cross-sectional area and muscular strength: a brief reviewSports Med 38 987
Jung, C. G. 1981 The Archetypes and the Collective UnconsciousPrinceton University Press
Kalender, W. A. 2005 Computer TomographyPublicis Corporate Publishing
Kang, Y.Engelke, K.Kalender, W. A. 2003 A new accurate and precise 3-D segmentation method for skeletal structures in volumetric CT dataIEEE Trans. Med. Imaging 22 586
Kanis, J. A.Oden, A.Johnell, O. 2007 The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and womenOsteoporos Int. 18 1033
Kannus, P.Sievanen, H.Vuori, I. 1996 Physical loading, exercise, and boneBone 18 1S
Karsenty, G. 2001 Leptin controls bone formation through a hypothalamic relayRecent Prog. Horm. Res. 56, 401
Kavukcuoglu, N. B.Patterson-Buckendahl, P.Mann, , A. B. 2009 Effect of osteocalcin deficiency on the nanomechanics and chemistry of mouse bonesJ. Mech. Behav. Biomed. Mater. 2 348
Keaveny, T. M.Pinilla, T. P.Crawford, R. P.Kopperdahl, D. L.Lou, A. 1997 Systematic and random errors in compression testing of trabecular boneJ. Orthop. Res. 15 101
Keyak, J. H.Meagher, J. M.Skinner, H. B.Mote, C. D. 1990 Automated three-dimensional finite element modelling of bone: a new methodJ. Biomed. Eng. 12 389
Khosla, S. 2001 Minireview: the OPG/RANKL/RANK systemEndocrinology 142 5050
Kleissen, R. F.Buurke, J. H.Harlaar, J.Zilvold, G. 1998 Electromyography in the biomechanical analysis of human movement and its clinical applicationGait Posture 8 143
Knothe Tate, M. L. 2003 Whither flows the fluid in bone?” An osteocyte’s perspectiveJ. Biomech. 36 1409
Kohl, P.Viceconti, M. 2010 The virtual physiological human: computer simulation for integrative biomedicine IIPhilos. Transact. A Math. Phys. Eng. Sci. 368 2837
Kohl, P.Coveney, P.Clapworthy, G.Viceconti, M. 2008 The virtual physiological human. EditorialPhilos. Transact. A Math. Phys. Eng. Sci. 366 3223
Krokos, M.Podgorelec, D.Clapworthy, G. J. 2005
Krum, S. A.Miranda-Carboni, G. A.Hauschka, P. V. 2008 Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survivalEMBO J. 27 535
Lattanzi, R.Baruffaldi, F.Zannoni, C.Viceconti, M. 2004 Specialised CT scan protocols for 3-D pre-operative planning of total hip replacementMed. Eng. Phys. 26 237
Laz, P. J.Stowe, J. Q.Baldwin, M. A.Petrella, A. J.Rullkoetter, P. J. 2007 Incorporating uncertainty in mechanical properties for finite element-based evaluation of bone mechanicsJ. Biomech. 40 2831
Leardini, A.Chiari, L.Della Croce, U.Cappozzo, A. 2005 Human movement analysis using stereophotogrammetry. Part 3. Soft tissue artifact assessment and compensationGait Posture 21 212
Leardini, A.Taddei, F.Manfrini, M.Viceconti, M.Benedetti, M. G. 2007 Gait analysis and bone model registration in patients operated on massive skeletal reconstruction: a weighted-joint technique for artifact reductionJ. Biomech. 40 S553
LeBlanc, A. D.Spector, E. R.Evans, H. J.Sibonga, J. D. 2007 Skeletal responses to space flight and the bed rest analog: a reviewJ. Musculoskelet. Neuronal Interact. 7 33
Lee, Y. S.Seon, J. K.Shin, V. I.Kim, G. H.Jeon, M. 2008 Anatomical evaluation of CT-MRI combined femoral modelBiomed. Eng. Online 7 6
Lemaire, T.Naili, S.Remond, A. 2006 Multiscale analysis of the coupled effects governing the movement of interstitial fluid in cortical boneBiomech. Model. Mechanobiol. 5 39
Le Novère, N.Finney, A.Hucka, M. 2005 Minimum information requested in the annotation of biochemical models (MIRIAM)Nat. Biotechnol. 23 1509
Lewis, G.Nyman, J. S. 2008 The use of nanoindentation for characterizing the properties of mineralized hard tissues: state-of-the art reviewJ. Biomed. Mater. Res. B Appl. Biomater. 87 286
Lieber, R. L.Fridén, J. 2000 Functional and clinical significance of skeletal muscle architectureMuscle Nerve 23 1647
Lord, S. R.Menz, H. B. 2002 Physiologic, psychologic, and health predictors of 6-minute walk performance in older peopleArch. Phys. Med. Rehabil. 83 907
Lu, T. W.O’Connor, J. J. 1999 Bone position estimation from skin marker co-ordinates using global optimisation with joint constraintsJ. Biomech. 32 129
Luo, G.Ducy, P.McKee, M. D. 1997 Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA proteinNature 386 78
Manchikanti, L.Fellows, B.Pampati, V. 2002 Comparison of psychological status of chronic pain patients and the general populationPain Physician 5 40
Manfrini, M.Innocenti, M.Ceruso, M.Mercuri, M. 2003 Original biological reconstruction of the hip in a 4-year-old girlLancet 361 140
Marulanda, G. A.Henderson, E. R.Johnson, D. A.Letson, G. D.Cheong, D. 2008 Orthopedic surgery options for the treatment of primary osteosarcomaCancer Control 15 13
Matsumoto, T.Ohnishi, I.Bessho, M. 2009 Prediction of vertebral strength under loading conditions occurring in activities of daily living using a computed tomography-based nonlinear finite element methodSpine 34 1464
Matsuo, K.Irie, N. 2008 Osteoclast–osteoblast communicationArch. Biochem. Biophys. 473 201
Matthews, M. R. 2004 Idealisation and Galileo’s pendulum discoveries: historical, philosophical and pedagogical considerationsSci. & Educ. 13 689
Mayr, E. 1996 The autonomy of biology: the position of biology among the sciencesQ. Rev. Biol. 71 97
Mayr, E. 1998 This Is Biology: The Science of the Living WorldHarvard University Press
McNamara, L. M. 2010 Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fracturesJ. R. Soc. Interface 7 353
Melton, L. J.Christen, D.Riggs, B. L. 2010 Assessing forearm fracture risk in postmenopausal womenOsteoporos. Int. 21 1161
Mendez, J.Keys, A. 1960 Density and composition of mammalian muscleMetabolism 9 184
Menegaldo, L. L.de Toledo Fleury, A.Weber, H. I. 2006 A ‘cheap’ optimal control approach to estimate muscle forces in musculoskeletal systemsJ. Biomech. 39 1787
Merz, B.Müller, R.Ruegsegger, P. 1991 Interfaces in Medicine and Mechanics–2Williams, K. R.Toni, A.Middleton, J.Pallotti, G.Elsevier
Morasso, P. 1981 Spatial control of arm movementsExp. Brain Res. 42 223
Morgan, E. F.Bayraktar, H. H.Keaveny, T. M. 2003 Trabecular bone modulus–density relationships depend on anatomic siteJ. Biomech. 36 897
Morin, E. 1993 Il Metodo 3. La conoscenza della conoscenzaRaffaello Cortina Editore
Mueller, T. L.Stauber, M.Kohler, T. 2009 Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radiusBone 44 364
Muller, R. 2005 Long-term prediction of three-dimensional bone architecture in simulations of pre-, peri- and post-menopausal microstructural bone remodelingOsteoporos. Int. 16 S25
Nevill, A. M.Holder, R. L.Stewart, A. D. 2003 Modeling elite male athletes’ peripheral bone mass, assessed using regional dual X-ray absorptiometryBone 32 62
Noble, B. S. 2008 The osteocyte lineageArch. Biochem. Biophys. 473 106
Noble, D. 2002 Modeling the heart – from genes to cells to the whole organScience 295 1678
Noble, D. 2006 The Music of Life: Biology Beyond the GenomeOxford University Press
Nystrom, L. M.Morcuende, J. A. 2010 Expanding endoprosthesis for pediatric musculoskeletal malignancy: current concepts and resultsIowa Orthop. J. 30 141
Ogata, Y. 2008 Bone sialoprotein and its transcriptional regulatory mechanismJ. Periodontal Res. 43 127
Ohman, C.Baleani, M.Perilli, E. 2007 Mechanical testing of cancellous bone from the femoral head: experimental errors due to off-axis measurementsJ. Biomech. 40 2426
Ohman, C.Dall’Ara, E.Baleani, M.Van Sint Jan, S.Viceconti, M. 2008 The effects of embalming using a 4% formalin solution on the compressive mechanical properties of human cortical boneClin. Biomech. (Bristol, Avon) 23 1294
Öhman, C.Baleani, M.Viceconti, M. 2009
Pakarinen, T. K.Laine, H. J.Honkonen, S. E. 2002 Charcot arthropathy of the diabetic foot: current concepts and review of 36 casesScand. J. Surg. 91 195
Papachroni, K. K.Karatzas, D. N.Papavassiliou, K. A.Basdra, E. K.Papavassiliou, A. G. 2009 Mechanotransduction in osteoblast regulation and bone diseaseTrends Mol. Med 15 208
Parfitt, A. M. 2001 The bone remodeling compartment: a circulatory function for bone lining cellsJ. Bone Miner. Res. 16 1583
Pavol, M. J.Owings, T. M.Grabiner, M. D. 2002 Body segment inertial parameter estimation for the general population of older adultsJ. Biomech. 35 707
Peng, L.Bai, J.Zeng, X.Zhou, Y. 2006 Comparison of isotropic and orthotropic material property assignments on femoral finite element models under two loading conditionsMed. Eng. Phys. 28 227
Phan, C. M.Macklin, E. A.Bredella, M. A. 2010 Trabecular structure analysis using C-arm CT: comparison with MDCT and flat-panel volume CTSkeletal Radiol
Piscitelli, P.Brandi, M. L.Tarantino, U. 2010 Incidenza e costi delle fratture di femore in Italia: studio di estensione 2003–2005 [Incidence and socioeconomic burden of hip fractures in Italy: extension study 2003–2005]Reumatismo 62 113
Polgar, K.Gill, H. S.Viceconti, M.urray, D. W.O’Connor, J. J. 2003 Strain distribution within the human femur due to physiological and simplified loading: finite element analysis using the muscle standardized femur modelProc. Inst. Mech. Eng. H 217 173
Polkinghorne, J. C. 2007 www.disf.org/en/Voci/104.asp
Popper, K. R. 1992 The Logic of Scientific DiscoveryRoutledge
Popper, K. R. 1999 All Life is Problem SolvingRoutledge
Praagman, M.Chadwick, E. K.van der Helm, F. C.Veeger, H. E. 2006 The relationship between two different mechanical cost functions and muscle oxygen consumptionJ. Biomech. 39 758
Qin, Y. X.Lam, H.Ferreri, S.Rubin, C. 2010 Dynamic skeletal muscle stimulation and its potential in bone adaptationJ. Musculoskelet. Neuronal Interact. 10 12
Queipo, N. V.Haftka, R. T.Shyy, W. 2005 Surrogate-based analysis and optimizationProg. Aerosp. Sci. 41 1
Reid, I. R. 2008 Effects of beta-blockers on fracture riskJ. Musculoskelet. Neuronal. Interact. 8 105
Robling, A. G.Stout, S. D. 1999 Morphology of the drifting osteonCells Tissues Organs 164 192
Roeder, B. A.Kokini, K.Sturgis, J. E.Robinson, J. P.Harbin, S. L. 2002 Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructureJ. Biomech. Eng. 124 214
Rohrle, O.Pullan, A. J. 2007 Three-dimensional finite element modelling of muscle forces during masticationJ. Biomech. 40 3363
Roschger, P.Fratzl, P.Eschberger, J.Klaushofer, K. 1998 Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsiesBone 23 319
Rowland, R. E. 1966 Exchangeable bone calciumClin. Orthop. Relat. Res. 49 233
Rubin, L. A.Hawker, G. A.Peltekova, V. D. 1999 Determinants of peak bone mass: clinical and genetic analyses in a young female Canadian cohortJ. Bone Miner. Res. 14 633
Rubin, M. A.Jasiuk, I. 2005 The TEM characterization of the lamellar structure of osteoporotic human trabecular boneMicron 36 653
Sackett, D. L.Rosenberg, W. M.Gray, J. A.Haynes, R. B.Richardson, W. S. 1996 Evidence based medicine: what it is and what it isn’tBMJ 312 71
Sadowsky, O.Chintalapani, G.Taylor, R. H. 2007 Deformable 2D-3D registration of the pelvis with a limited field of view, using shape statisticsMed. Image Comput. Comput. Assist. Interv. 10 519
Sai, A. J.Gallagher, J. C.Smith, L. M.Logsdon, S. 2010 Fall predictors in the community dwelling elderly: a cross sectional and prospective cohort studyJ. Musculoskelet. Neuronal Interact. 10 142
Schiessl, H.Frost, H. M.Jee, W. S. 1998 Estrogen and bone-muscle strength and mass relationshipsBone 22 1
Schileo, E.Taddei, F.Malandrino, A.Cristofolini, L.Viceconti, M. 2007 Subject-specific finite element models can accurately predict strain levels in long bonesJ. Biomech. 40 2982
Schmid, J.Magnenat-Thalmann, N. 2008 MRI bone segmentation using deformable models and shape priorsMed. Image. Comput. Comput. Assist. Interv. 11 119
Scholz, J. P.Schoner, G. 1999 The uncontrolled manifold concept: identifying control variables for a functional taskExp. Brain Res. 126 289
Schulte, F. A.Lambers, F. M.Kuhn, G.Muller, R. 2010 In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imagingBone 48 433
Seireg, A.Arvikar, R. J. 1975 The prediction of muscular load sharing and joint forces in the lower extremities during walkingJ. Biomech. 8 89
Serway, R. A. 1995 www.physlink.com/reference/FrictionCoefficients.cfm
Settle, T. 1989 Van Rooijen and Mayr versus Popper: is the universe causally closed?Br. J. Philos. Sci. 40 398
Shea, J. E.Miller, S. C. 2005 Skeletal function and structure: implications for tissue-targeted therapeuticsAdv. Drug Deliv. Rev. 57 945
Shen, Z. L.Dodge, M. R.Kahn, H.Ballarini, R.Eppell, S. J. 2008 Stress–strain experiments on individual collagen fibrilsBiophys. J. 95 3956
Shirazi-Adl, A. 1994 Analysis of role of bone compliance on mechanics of a lumbar motion segmentJ. Biomech. Eng. 116 408
Sievanen, H. 2010 Immobilization and bone structure in humansArch. Biochem. Biophys. 503 146
Silver, F. H. 2009 The importance of collagen fibers in vertebrate biologyJ. Eng.Fiber. Fabr. 4 9
Singh, P. K.Marzo, A.Howard, B. 2010 Effects of smoking and hypertension on wall shear stress and oscillatory shear index at the site of intracranial aneurysm formationClin. Neurol. Neurosurg. 112 306
Skedros, J. G.Mendenhall, S. D.Kiser, C. J.Winet, H. 2009 Interpreting cortical bone adaptation and load history by quantifying osteon morphotypes in circularly polarized light imagesBone 44 392
Skerry, T. M. 1997 Mechanical loading and bone: what sort of exercise is beneficial to the skeleton?Bone 20 179
Skerry, T. M. 2008 The response of bone to mechanical loading and disuse: fundamental principles and influences on osteoblast/osteocyte homeostasisArch. Biochem. Biophys. 473 117
Standal, T.Borset, M.Sundan, A. 2004 Role of osteopontin in adhesion, migration, cell survival and bone remodelingExp. Oncol. 26 179
STEP Consortium 2007 www.europhysiome.org/roadmap
Strang, G.Fix, G. 2008 An Analysis of the Finite Element MethodWellesley
Strasser, S.Zink, A.Janko, M.Heckl, W. M.Thalhammer, S. 2007 Structural investigations on native collagen type I fibrils using AFMBiochem. Biophys. Res. Commun. 354 27
Tabor, Z.Rokita, E. 2007 Quantifying anisotropy of trabecular bone from gray-level imagesBone 40 966
Taddei, F.Viceconti, M.Manfrini, M.Toni, A. 2003 Mechanical strength of a femoral reconstruction in paediatric oncology: a finite element studyProc. Inst. Mech. Eng. H 217 111
Taddei, F.Stagni, A.Cappello, M. 2005 Kinematic study of a reconstructed hip in paediatric oncologyMed. Biol. Eng. Comput. 43 102
Taddei, F.Martelli, S.Reggiani, B.Cristofolini, L.Viceconti, M. 2006 Finite-element modeling of bones from CT data: sensitivity to geometry and material uncertaintiesIEEE Trans. Biomed. Eng. 53 2194
Taddei, F.Schileo, E.Helgason, B.Cristofolini, L.Viceconti, M. 2007 The material mapping strategy influences the accuracy of CT-based finite element models of bones: an evaluation against experimental measurementsMed. Eng. Phys. 29 973
Taddei, F.Pani, M.Zovatto, L.Tonti, E.Viceconti, M. 2008 A new meshless approach for subject-specific strain prediction in long bones: evaluation of accuracyClin. Biomech. (Bristol, Avon) 23 1192
Taghavi, R. 1996 Automatic, parallel and fault tolerant mesh generation from CADEng. Comput. 12 178
Takeda, S.Elefteriou, F.Levasseur, R. 2002 Leptin regulates bone formation via the sympathetic nervous systemCell 111 305
Takeuchi, T.Gonda, T. 2004 Distribution of the pores of epithelial basement membrane in the rat small intestineJ. Vet. Med. Sci. 66 695
Tang, Y.Ballarini, R.Buehler, M. J.Eppell, S. J. 2010 Deformation micromechanisms of collagen fibrils under uniaxial tensionJ. R. Soc. Interface 7 839
Tassani, S.Ohman, C.Baleani, M.Baruffaldi, F.Viceconti, M. 2010 Anisotropy and inhomogeneity of the trabecular structure can describe the mechanical strength of osteoarthritic cancellous boneJ. Biomech 43 1160
Tassani, S.Ohman, C.Baruffaldi, F.Baleani, M.Viceconti, M. 2011 Volume to density relation in adult human bone tissueJ. Biomech. 44 103
Taylor, C. F.Field, D.Sansone, S. A. 2008 Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI projectNat. Biotechnol 26 889
Testi, D.Zannoni, C.Cappello, A.Viceconti, M. 2001 Border-tracing algorithm implementation for the femoral geometry reconstructionComput. Methods Programs Biomed. 65 175
Testi, D.Quadrani, P.Viceconti, M. 2010 PhysiomeSpace: digital library service for biomedical dataPhilos. Transact. A Math. Phys. Eng. Sci. 368 2853
Thelen, D. G.Anderson, F. C.Delp, S. L. 2003 Generating dynamic simulations of movement using computed muscle controlJ. Biomech. 36 321
Theoleyre, S.Wittrant, Y.Tat, S. K. 2004 The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodelingCytokine Growth Factor Rev. 15 457
Thiel, R.Stroetmann, K. A.Stroetmann, V. N.Viceconti, M. 2009 Designing a socio-economic assessment method for integrative biomedical research: the Osteoporotic Virtual Physiological Human projectStud. Health Technol. Inform. 150 876
Todorov, E.Jordan, M. I. 2002 Optimal feedback control as a theory of motor coordinationNat. Neurosci. 5 1226
Tonti, E. 2001 A direct discrete formulation of field laws: the cell methodComput. Model. Eng. Sci. 2 237
Truc, P. T.Kim, T. S.Lee, S.Lee, Y. K. 2009 A study on the feasibility of active contours on automatic CT bone segmentationJ. Digit. Imaging 22 793
Tsirakos, D.Baltzopoulos, V.Bartlett, R. 1997 Inverse optimization: functional and physiological considerations related to the force-sharing problemCrit. Rev. Biomed. Eng. 25 371
Turner, C. H.Robling, A. G. 2005 Mechanisms by which exercise improves bone strengthJ. Bone Miner. Metab. 23 16
van der Linden, J. C.Day, J. S.Verhaar, J. A.Weinans, H. 2004 Altered tissue properties induce changes in cancellous bone architecture in aging and diseasesJ. Biomech. 37 367
van der Plas, A.Nijweide, P. J. 1992 Isolation and purification of osteocytesJ. Bone. Miner. Res. 7 389
van Lenthe, G. H.Mueller, T. L.Wirth, A. J.Muller, R. 2008 Quantification of bone structural parameters and mechanical competence at the distal radiusJ. Orthop. Trauma 22 S66
van Oers, R. F.Ruimerman, R.Tanck, E.Hilbers, P. A.Huiskes, R. 2008 A unified theory for osteonal and hemi-osteonal remodelingBone 42 250
Van Rietbergen, B.Weinans, H.Huiskes, R.Polman, B. J. W. 1996 Computational strategies for iterative solutions of large FEM applications employing voxel dataInt. J. Numer. Methods Eng. 39 2743
Van Sint Jan, S. 2007 Color Atlas of Skeletal Landmark Definitions: Guidelines for Reproducible Manual and Virtual PalpationsChurchill Livingstone
Van Sint Jan, S.Sobzack, S.Dugailly, P. M. 2006 Low-dose computed tomography: a solution for in vivo medical imaging and accurate patient-specific 3D bone modeling?Clin. Biomech. (Bristol, Avon) 21 992
Viceconti, M.Clapworthy, G. 2006
Viceconti, M.Kohl, P. 2010 The virtual physiological human: computer simulation for integrative biomedicine IPhilos. Transact. A Math. Phys. Eng. Sci. 368 2591
Viceconti, M.Taddei, F. 2003 Automatic generation of finite element meshes from computed tomography dataCrit. Rev. Biomed. Eng. 31 27
Viceconti, M.Bellingeri, L.Cristofolini, L.Toni, A. 1998 A comparative study on different methods of automatic mesh generation of human femursMed. Eng. Phys. 20 1
Viceconti, M.Olsen, S.Nolte, L. P.Burton, K. 2005 Extracting clinically relevant data from finite element simulationsClin. Biomech. (Bristol, Avon) 20 451
Viceconti, M.Brusi, G.Pancanti, A.Cristofolini, L. 2006 Primary stability of an anatomical cementless hip stem: a statistical analysisJ. Biomech. 39 1169
Viceconti, M.Testi, D.Taddei, F. 2006 Biomechanics Modeling of the Musculoskeletal Apparatus: Status and Key IssuesProceedings of the IEEE 94 725
Viceconti, M.Taddei, F.Montanari, L. 2007 Multimod Data Manager: a tool for data fusionComput. Methods Programs Biomed. 87 148
Viceconti, M.Clapworthy, G.Van Sint Jan, S. 2008 The Virtual Physiological Human – a European initiative for in silico human modellingJ. Physiol. Sci 58 441
Viceconti, M.Taddei, F.Van Sint Jan, S. 2008 Multiscale modelling of the skeleton for the prediction of the risk of fractureClin. Biomech. (Bristol, Avon) 23 845
Viceconti, M.Clapworthy, G.Testi, D.Taddei, F.McFarlane, N. 2010 Multimodal fusion of biomedical data at different temporal and dimensional scalesComput. Methods Programs Biomed 102 227
Wang, J. H.Thampatty, B. P. 2006 An introductory review of cell mechanobiologyBiomech. Model. Mechanobiol. 5 1
Wang, Y. C.Chen, B. S 2010 Integrated cellular network of transcription regulations and protein-protein interactionsBMC Syst Biol.20
Watts, N. B. 1999 Clinical utility of biochemical markers of bone remodelingClin. Chem. 45 1359
Webster, D.Wasserman, E.Ehrbar, M. 2010 Mechanical loading of mouse caudal vertebrae increases trabecular and cortical bone mass-dependence on dose and genotypeBiomech. Model. Mechanobiol. 9 737
Weiner, S.Traub, W. 1992 Bone structure: from angstroms to micronsFASEB J 6 879
Weiner, S.Arad, T.Sabanay, I.Traub, W. 1997 Rotated plywood structure of primary lamellar bone in the rat: orientations of the collagen fibril arraysBone 20 509
Weiss, L. 1988 Cell and Tissue Biology: A Textbook of HistologyUrban & Schwarzenberg
Wikipedia, 2008 http://en.wikipedia.org/wiki/Reductionism
Winby, C. R.Lloyd, D. G.Kirk, T. B. 2008 Evaluation of different analytical methods for subject-specific scaling of musculotendon parametersJ. Biomech. 41 1682
Wu, C. F. J. 1986 Jackknife, bootstrap and other resampling methods in regression analysisAnn. Stat. 14 1261
Wu, G.Siegler, S.Allard, P. 2002 ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion – part I: ankle, hip, and spineJ. Biomech. 35 543
Wu, G.van der Helm, F. C.Veeger, H. E. 2005 ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion – Part II: shoulder, elbow, wrist and handJ. Biomech. 38 981
Yamaguchi, F. 2002 Computer-Aided Geometric Design: A Totally Four-Dimensional ApproachSpringer Verlag
Yamaguchi, G. A. 1990 Multiple Muscle Systems: Biomechanics and Movement OrganizationWinters, L.-Y. Woo, S.Springer-Verlag
Yamaguchi, G. T. 2001 Dynamic Modeling of Musculoskeletal Motion: A Vectorized Approach for Biomechanical Analysis in Three DimensionsSpringer Verlag
Yamashita, J.Li, X.Furman, B. R. 2002 Collagen and bone viscoelasticity: a dynamic mechanical analysisJ. Biomed. Mater. Res. 63 31
Yang, L.van der Werf, K. O.Fitie, C. F. 2008 Mechanical properties of native and cross-linked type I collagen fibrilsBiophys. J. 94 2204
Yao, J.Salo, A. D.Lee, J.Lerner, A. L. 2008 Sensitivity of tibio-menisco-femoral joint contact behavior to variations in knee kinematicsJ. Biomech. 41 390
Yoon, Y. J.Cowin, S. C. 2008 The estimated elastic constants for a single bone osteonal lamellaBiomech. Model. Mechanobiol. 7 1
Yosibash, Z.Tal, D.Trabelsi, N. 2010 Predicting the yield of the proximal femur using high-order finite-element analysis with inhomogeneous orthotropic material propertiesPhilos. Transact. A Math. Phys. Eng. Sci. 368 2707
Yu, H.Wooley, P. H.Yang, S.-Y. 2009 Biocompatibility of poly-epsilon-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cellsJ. Orthop. Surg. Res. 4 5
Yucesoy, C. A.Koopman, B. H.Baan, G. C.Grootenboer, H. J.Huijing, P. A. 2003 Effects of inter- and extramuscular myofascial force transmission on adjacent synergistic muscles: assessment by experiments and finite-element modelingJ. Biomech. 36 1797
Zajac, F. E. 1989 Muscle and tendon: properties, models, scaling, and application to biomechanics and motor controlCrit. Rev. Biomed. Eng. 17 359
Zannoni, C.Cappello, A.Viceconti, M. 1998 Optimal CT scanning plan for long-bone 3-D reconstructionIEEE Trans. Med. Imaging 17 663
Zienkiewicz, O. C.Taylor, R. L. 2005 The Finite Element Method for Solid and Structural MechanicsButterworth-Heinemann
Zovatto, L.Nicolini, M. 2003 The meshless approach for the cell method: a new way for the numerical solution of the discrete conservation lawsInt. J. Comput. Methods Eng. Sci. Mech. 4 869
Zovatto, L.Nicolini, M. 2006 Extension of the meshless approach for the cell method to three-dimensional numerical integration of discrete conservation lawsInt. J. Comput. Methods Eng. Sci. Mech. 7 69
