Targeting Oncogenic Driver Mutations in Lung Cancer

Matthew Lee; Fawzi Abu Rous; Alain Borczuk; Stephen Liu; Shirish Gadgeel; Balazs Halmos

doi:10.1017/9781009336123

Series: Elements in Molecular Oncology

Targeting Oncogenic Driver Mutations in Lung Cancer

Published online by Cambridge University Press: 12 January 2023

Shirish Gadgeel and

Matthew Lee: Affiliation:
Montefiore Medical Center and Albert Einstein College of Medicine
Fawzi Abu Rous: Affiliation:
Henry Ford Health System
Alain Borczuk: Affiliation:
Weill Cornell Medicine
Stephen Liu: Affiliation:
Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC
Shirish Gadgeel: Affiliation:
Henry Ford Health System
Balazs Halmos: Affiliation:
Montefiore Medical Center and Albert Einstein College of Medicine

Summary

The recent advances in the field of molecular diagnostic techniques have led to the identification of targetable alterations prompting a paradigm shift in the management of non-small cell lung cancer (NSCLC) and an era of precision oncology. This Element highlights the most clinically relevant oncogenic drivers other than EGFR, their management and current advancements in treatment. It also examines the different challenges in resistance to targeted therapies and diagnostic dilemmas for each oncogenic driver and the future direction of NSCLC management.

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Keywords

non-small cell lung cancer targetable mutations/alterations resistance mechanisms diagnostic techniques driver mutations

Type: Element
Information: Series: Elements in Molecular Oncology

DOI: https://doi.org/10.1017/9781009336123 [Opens in a new window]

Online ISBN: 9781009336123

Publisher: Cambridge University Press

Print publication: 02 February 2023

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Targeting Oncogenic Driver Mutations in Lung Cancer

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