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An fMRI study of face encoding and recognition in first-episode schizophrenia

Published online by Cambridge University Press:  24 June 2014

Anantha P. P. Anilkumar ,
Veena Kumari ,
Ravi Mehrotra ,
Ingrid Aasen ,
Martina T. Mitterschiffthaler  and
Tonmoy Sharma
Anantha P. P. Anilkumar*
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK
Veena Kumari
Affiliation:
Department of Psychology, Institute of Psychiatry, King’s College London, London, UK
Ravi Mehrotra
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK
Ingrid Aasen
Affiliation:
Division of Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK
Martina T. Mitterschiffthaler
Affiliation:
Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, UK
Tonmoy Sharma
Affiliation:
Clinical Neuroscience Research Centre, Dartford, Kent, UK
*
Dr A.P.P. Anilkumar, MBBS MRC Psych, Room 51, Outpatient Department, Maudsley Hospital, London SE5 8AZ, UK. Tel: 020 7378 6383; Fax: 020 7378 6870; E-mail: anil.kumar@slam.nhs.uk
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Abstract

Background:

Schizophrenia has been associated with limited abilities to interact effectively in social situations. Face perception and ability to recognise familiar faces are critical for social interaction. Patients with chronic schizophrenia are known to show impaired face recognition. Studying first-episode (FE) patients allows the exclusion of confounding effects of chronicity, medication and institutionalisation in this deficit.

Objective:

To determine brain (dys)functions during a face encoding and recognition paradigm in FE schizophrenia.

Methods:

Thirteen antipsychotic-naïve FE schizophrenia patients and 13 age- and sex-matched healthy controls underwent functional magnetic resonance imaging during a face encoding and recognition paradigm. Behavioural responses were recorded on line.

Results:

Patients recognised significantly fewer of previously presented faces than the controls (p = 0.008). At the neural level, both groups activated a network of regions including the fusiform area, occipital, temporal and frontal regions. In brain activity, the two groups did not differ in any region during encoding or recognition conditions (p > 0.05, corrected or uncorrected).

Conclusions:

Our findings show impaired face recognition without a significant alteration of related brain activity in FE schizophrenia patients. It is possible that neural changes become more strongly evident with progression of the illness, and manifest themselves as behavioural impairments during the early course.

Keywords

face processingfMRIencodinghippocampuspsychosisrecognition
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 3 , June 2008 , pp. 129 - 138
Copyright
Copyright © 2008 Blackwell Munksgaard

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