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Differential BOLD responses to auditory target stimuli associated with a skin conductance response

Published online by Cambridge University Press:  24 June 2014

Jim Lagopoulos ,
Evian Gordon  and
Philip B. Ward
Jim Lagopoulos*
Affiliation:
School of Psychiatry, University of NSW, Sydney, Australia Mayne Clinical Research Imaging Centre, Randwick, Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Sydney, Australia
Evian Gordon
Affiliation:
Brain Dynamics Centre, Westmead Hospital, NSW, Australia Department of Psychological Medicine, The University of Sydney, NSW, Australia
Philip B. Ward
Affiliation:
School of Psychiatry, University of NSW, Sydney, Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Sydney, Australia
*
Dr Jim Lagopoulos, Mayne Clinical Research Imaging Centre, Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia. Tel: +61 2 93822998; Fax: +61 2 93828208; E-mail: jim.lagopoulos@unsw.edu.au
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Abstract

Background:

The orienting reflex (OR) is a fundamental biological mechanism thought to reflect automatic adaptive processing of environmental stimuli necessary for successful interaction with the environment. It has been hypothesized that the OR is generated in response to novelty such as in the case where a mismatch results between an internal neuronal template stored in working memory and incoming stimuli. Recent blood oxygenated level dependant (BOLD) activation studies that have investigated networks involved in the processing of novelty have suggested the recruitment of a distributed limbic-neocortical network. In the present study, event-related functional resonance imaging with simultaneous autonomic electrodermal activity was used to detect single trials of an auditory oddball task associated with the OR.

Results:

The pattern of activations indicated two distinct, but partially overlapping, networks. Predominantly, frontal activations were seen for the target stimuli that did elicit an OR, including the orbitofrontal gyrus and anterior cingulate gyrus, as well as activations in the anterior thalamus and cerebellum. On contrary, parietal activations including the supramarginal gyrus and precuneus were seen for the target stimuli that that did not elicit an OR.

Keywords

fMRISCRorienting reflexoddballtarget detection
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 2 , April 2006 , pp. 105 - 114
Copyright
Copyright © 2006 Blackwell Munksgaard

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