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Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study

Published online by Cambridge University Press:  16 October 2023

Qianli Liu ,
Lan Wang ,
Fengya Zhen  and
Cuixia An Open the ORCID record for Cuixia An [Opens in a new window]
Qianli Liu
Affiliation:
Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang, China The Mental Health Institute of Hebei Medical University, Shijiazhuang, China Hebei Brain Ageing and Cognitive Neuroscience Laboratory, Shijiazhuang, China Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang, China
Lan Wang
Affiliation:
Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang, China The Mental Health Institute of Hebei Medical University, Shijiazhuang, China Hebei Brain Ageing and Cognitive Neuroscience Laboratory, Shijiazhuang, China Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang, China
Fengya Zhen
Affiliation:
Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang, China The Mental Health Institute of Hebei Medical University, Shijiazhuang, China Hebei Brain Ageing and Cognitive Neuroscience Laboratory, Shijiazhuang, China Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang, China
Cuixia An*
Affiliation:
Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang, China The Mental Health Institute of Hebei Medical University, Shijiazhuang, China Hebei Brain Ageing and Cognitive Neuroscience Laboratory, Shijiazhuang, China Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease, Shijiazhuang, China
*
Corresponding author: Cuixia An; Email: acxsunny@sina.com
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Abstract

Objective:

This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders.

Methods:

A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination centre of our hospital were selected as the control group. The participants enrolled were assessed for general demographic data, case characteristics, and metabolic indexes including body mass index (BMI), blood pressure, triglyceride, high-density lipoprotein-cholesterol, cholesterol, low-density lipoprotein-cholesterol, and fasting plasma glucose.

Results:

The incidence of metabolic syndrome in the bipolar disorders group was higher compared to the control group (9.6% VS. 8.5%). After calibrating sex and age data, a significant difference between the two groups was observed (P < 0.05). Diastolic and systolic blood pressure were higher in the bipolar disorders group compared to the control group (P < 0.01). Men with bipolar disorders had a higher risk of developing metabolic syndrome than women (14.5% vs. 5.8%). Bipolar disorders, sex, age, and BMI were identified as independent risk factors for metabolic syndrome. No significant difference was found in terms of metabolic index and incidence of metabolic syndrome between individuals with depressive episodes (n = 37) and manic episodes (n = 75).

Conclusion:

Patients with bipolar disorders were found to have a higher risk of developing metabolic syndrome than healthy individuals. Bipolar disorders, male sex, age, and BMI may contribute to an increased risk of developing metabolic syndrome.

Keywords

Bipolar disordersmetabolic syndromeuntreated
Type
Original Article
Information
Acta Neuropsychiatrica , First View , pp. 1 - 6
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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