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Serotoninergic findings in habitual violence and impulsivity. A review*

Published online by Cambridge University Press:  18 September 2015

M.D. Virkkunen
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Summary

Several lines of evidence suggest that there may be abnormal brain serotonin metabolism in habitually biolent and impulsive offenders. These personality disorders are usually connected with early onset, male limited type 2 alcoholism in which one central feature is the abnormal tendency to behave aggressively and impulsively under the influence of alcohol repeatedly. Low CSF 5-HIAA has been found to correlate with familial alcoholism tendencies; paternal alcoholism. Both this and with it the tendency to abnormal oral glucose tolerance test (tendency to low blood glucose nadir) predict the new violent and impulsive crimes under the influence of alcohol. Also peripheral measures such as platelet MAO, abnormal tryptophan/LNAA ratio in plasma, whole blood serotonin, blood platelet uptake of serotonin, platelet 3H-IMI dinging (Bmax), abnormal prolactin and Cortisol secretion in fenfluramine challenge, and possibly daily urinary free Cortisol secretion correlate with impulsive aggressive behavior.

Keywords

impulsivityviolencetype 2 alcoholismbrain serotonin metabolismperipheral serotonin functionsdrug treatmentsimpulsiviteittype-2-alcoholismeserotoninemetabolisme in hersenenperifere serotoni-nefunctiesbehandelingen met geneesmiddelen
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 2 , Issue 3 , September 1990 , pp. 66 - 71
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1990

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Footnotes

*

Met toestemming van de auteur vertaald door dr. T.B. Vree.

References

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