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Visually evoked potentials, NMDA receptors and the magnocellular system in schizophrenia

Published online by Cambridge University Press:  24 June 2014

Bernt C. Skottun  and
John R. Skoyles
Bernt C. Skottun
Affiliation:
Ullevålsalleen 4C, 0852 Oslo, Norway
John R. Skoyles
Affiliation:
Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London, UK Centre for Philosophy of Natural and Social Science (CPNSS), London School of Economics, London, UK
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Extract

Background: It has been claimed that schizophrenia can be linked to the magnocellular system by way of N-methyl-d-aspartate (NMDA) receptors. The present report examines this claim.

Methods: A review is made of relevant research literature.

Results: The NMDA studies that have been referenced to connect visual deficits in schizophrenia to the magnocellular system are based on the cat, a species whose visual system is fundamentally different from that of primates. The cat visual system cannot easily be divided into magno- and a parvocellular portions.

Conclusions: Owing to the substantial differences between the visual systems of cats and primates, it is difficult to link sensory abnormalities in schizophrenia specifically to the magnocellular system based on data from the cat.

Keywords

catlateral geniculate nucleusmonkeymotionparvocellularvision
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 1 , February 2012 , pp. 50 - 55
Copyright
Copyright © Cambridge University Press 2011

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