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Stimulation-induced side effects after deep brain stimulation – a systematic review

Published online by Cambridge University Press:  14 October 2019

Marcin Zygmunt Zarzycki Open the ORCID record for Marcin Zygmunt Zarzycki [Opens in a new window]  and
Izabela Domitrz
Marcin Zygmunt Zarzycki*
Affiliation:
Department of Neurology, 2nd Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland
Izabela Domitrz
Affiliation:
Department of Neurology, 2nd Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland
*
Author for correspondence: Marcin Zygmunt Zarzycki, E-mail: marcin.zarzycky@gmail.com
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Abstract

Objective:

Deep brain stimulation (DBS) was approved by Food and Drug Administration for Parkinson’s disease, essential tremor, primary generalised or segmental dystonia and obsessive-compulsive disorder (OCD) treatment. The exact mechanism of DBS remains unclear which causes side effects. The aim of this review was to assess variables causing stimulation-induced chronic psychiatric/personality-changing side effects.

Methods:

The analysis of scientific database (PubMed, Cochrane Library, EMBASE) was conducted. The included articles had to be research study or case report and DBS to be conducted in therapeutic purposes. The researches with mental disorders in patients’ medical histories were excluded.

Results:

Seventeen articles were used in the review. In the group of movement disorders the characteristic of side effects was strongly related to the placement of the electrode implantation. Tiredness/fatigue was correlated with DBS in thalamus. Implantations in subthalamic nucleus were mostly followed by affective side effects such as depression or suicide. The higher voltage of electrode was connected with more severe depression after implantation. The analysis of affective disorder contained only three articles – two about OCD and one about depression. Forgetfulness and word-finding problems as activities connected with cognition may be an inevitable side effect if obsessive thoughts are to be inhibited.

Conclusion:

DBS of subthalamic nucleus should be seen as the most hazardous place of implantation. As a result there is a strong need of ‘gold standards’ based on the connectivity research and closer cooperation of scientists and clinicians.

Keywords

central nervous systemdeep brain stimulationneural networksParkinson’s diseasepsychiatric disorders
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 32 , Issue 2 , April 2020 , pp. 57 - 64
Copyright
© Scandinavian College of Neuropsychopharmacology 2019

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References

Ackermans, L, Duits, A, van der Linden, C, Tijssen, M, Schruers, K, Temel, Y, Kleijer, M, Nederveen, P, Bruggeman, R, Tromp, S, van Kranen-Mastenbroek, V, Kingma, H, Cath, D and Visser-Vandewalle, V (2011) Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome. Brain 134, 832–844.CrossRefGoogle ScholarPubMed
Ackermans, L, Temel, Y, Cath, D, van der Linden, C, Bruggeman, R, Kleijer, M, Nederveen, P, Schruers, K, Colle, H, Tijssen, MA and Visser-Vandewalle, V (2006) Deep brain stimulation in Tourette’s syndrome: two targets? Movement Disorders 21, 709–713.CrossRefGoogle ScholarPubMed
Beric, A, Kelly, PJ, Rezai, A, Sterio, D, Mogilner, A, Zonenshayn, M and Kopell, B (2001) Complications of deep brain stimulation surgery. Stereotactic and Functional Neurosurgery 77, 73–78.CrossRefGoogle ScholarPubMed
Berridge, KC and Kringelbach, ML (2015) Pleasure systems in the brain. Neuron 86, 646–664.CrossRefGoogle Scholar
Bewernick, BH, Hurlemann, R, Matusch, A, Kayser, S, Grubert, C, Hadrysiewicz, B, Axmacher, N, Lemke, M, Cooper-Mahkorn, D, Cohen, MX, Brockmann, H, Lenartz, D, Sturm, V and Schlaepfer, TE (2010) Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biological Psychiatry 67, 110–116.CrossRefGoogle ScholarPubMed
Blum, K, Badgaiyan, RD and Gold, MS (2015) Hypersexuality addiction and withdrawal: phenomenology, neurogenetics and epigenetics. Cureus 7, e348.Google ScholarPubMed
Børretzen, MN, Bjerknes, S, Sæhle, T, Skjelland, M, Skogseid, IM, Toft, M and Dietrichs, E (2014) Long-term follow-up of thalamic deep brain stimulation for essential tremor – patient satisfaction and mortality. BMC Neurology 14, 120.CrossRefGoogle ScholarPubMed
Brunenberg, EJ, Moeskops, P, Backes, WH, Pollo, C, Cammoun, L, Vilanova, A, Janssen, ML, Visser-Vandewalle, VE, ter Haar Romeny, BM, Thiran, JP and Platel, B (2012) Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. PLoS One 7, e39061.CrossRefGoogle ScholarPubMed
Burkhard, PR, Vingerhoets, FJ, Berney, A, Bogousslavsky, J, Villemure, JG and Ghika, J (2004) Suicide after successful deep brain stimulation for movement disorders. Neurology 63, 2170–2172.CrossRefGoogle ScholarPubMed
Bush, G, Luu, P and Posner, MI (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences 4, 215–222.CrossRefGoogle ScholarPubMed
Cheattle, MD (2011) Depression, chronic pain, and suicide by overdose: on the edge. Pain Medicine 12, S43–S48.CrossRefGoogle Scholar
Codling, D, Shaw, P and David, AS (2015) Hypersexuality in Parkinson’s disease: systematic review and report of 7 new cases. Movement Disorders Clinical Practice 2, 116–126.CrossRefGoogle ScholarPubMed
Coenen, VA, Honey, CR, Hurwitz, T, Rahman, AA, McMaster, J, Bürgel, U and Mädler, B (2009) Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson’s disease. Neurosurgery 64, 1106–1114.CrossRefGoogle ScholarPubMed
Cyron, D (2016) Mental side effects of deep brain stimulation (DBS) for movement disorders: the futility of denial. Frontiers in Integrative Neuroscience 10, 17.CrossRefGoogle ScholarPubMed
Denys, D, Mantione, M, Figee, M, van den Munckhof, P, Koerselman, F, Westenberg, H, Bosch, A and Schuurman, R (2010) Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Archives of General Psychiatry 67, 1061–1068.CrossRefGoogle ScholarPubMed
Deuschl, G, Schade-Brittinger, C, Krack, P, Volkmann, J, Schäfer, H, Bötzel, K, Daniels, C, Deutschländer, A, Dillmann, U, Eisner, W, Gruber, D, Hamel, W, Herzog, J, Hilker, R, Klebe, S, Kloss, M, Koy, J, Krause, M, Kupsch, A, Lorenz, D, Lorenzl, S, Mehdorn, HM, Moringlane, JR, Oertel, W, Pinsker, MO, Reichmann, H, Reuss, A, Schneider, GH, Schnitzler, A, Steude, U, Sturm, V, Timmermann, L, Tronnier, V, Trottenberg, T, Wojtecki, L, Wolf, E, Poewe, W and Voges, J (2006) Neurostimulation section. A randomized trial of deep-brain stimulation for Parkinson’s disease. New England Journal of Medicine 355, 896–908.CrossRefGoogle ScholarPubMed
Doshi, P and Bhargava, P (2008) Hypersexuality following subthalamic nucleus stimulation for Parkinson’s disease. Neurology India 56, 474–476.Google ScholarPubMed
Drevets, WC (2007) Orbitofrontal cortex function and structure in depression. Annals of the New York Academy of Sciences 1121, 499–527.CrossRefGoogle ScholarPubMed
Eckert, U, Metzger, CD, Buchmann, JE, Kaufmann, J, Osoba, A, Li, M, Safron, A, Liao, W, Steiner, J, Bogerts, B and Walter, M (2012) Preferential networks of the mediodorsal nucleus and centromedian–parafascicular complex of the thalamus – a DTI tractography study. Human Brain Mapping 33, 2627–2637.CrossRefGoogle ScholarPubMed
Evans, AH, Strafella, AP, Weintraub, D and Stacy, M (2009) Impulsive and compulsive behaviors in Parkinson’s disease. Movement Disorders 24, 1561–1570.CrossRefGoogle ScholarPubMed
Fénelon, G, Mahieux, F, Huon, R and Ziégler, M (2000) Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors. Brain 123, 733–745.CrossRefGoogle ScholarPubMed
Figee, M, Luigjes, J, Smolders, R, Valencia-Alfonso, CE, van Wingen, G, de Kwaasteniet, B, Mantione, M, Ooms, P, de Koning, P, Vulink, N, Levar, N, Droge, L, van den Munckhof, P, Schuurman, PR, Nederveen, A, van den Brink, W, Mazaheri, A, Vink, M and Denys, D (2013) Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature Neuroscience 16, 386–387.CrossRefGoogle ScholarPubMed
Geday, J, Ostergaard, K, Gjedde, A (2006) Stimulation of subthalamic nucleus inhibits emotional activation of fusiform gyrus. Neuroimage 33, 706–714.CrossRefGoogle ScholarPubMed
Greenberg, BD, Malone, DA, Friehs, GM, Rezai, AR, Kubu, CS, Malloy, PF, Salloway, SP, Okun, MS, Goodman, WK and Rasmussen, SA (2006) Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 31, 2384–2393.CrossRefGoogle ScholarPubMed
Haq, IU, Foote, KD, Goodman, WK, Ricciuti, N, Ward, H, Sudhyadhom, A, Jacobson, CE, Siddiqui, MS and Okun, MS (2010) A case of mania following deep brain stimulation for obsessive compulsive disorder. Stereotactic and Functional Neurosurgery 88, 322–328.CrossRefGoogle ScholarPubMed
Johansen-Berg, H, Gutman, DA, Behrens, TE, Matthews, PM, Rushworth, MF, Katz, E, Lozano, AM and Mayberg, HS (2008) Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cerebral Cortex 18, 1374–1383.CrossRefGoogle ScholarPubMed
Kennedy, SH, Giacobbe, P, Rizvi, SJ, Placenza, FM, Nishikawa, Y, Mayberg, HS and Lozano, AM (2011) Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 Years. American Journal of Psychiatry 168, 502–510.CrossRefGoogle ScholarPubMed
Knight, EJ, Testini, P, Min, HK, Gibson, WS, Gorny, KR, Favazza, CP, Felmlee, JP, Kim, I, Welker, KM, Clayton, DA, Klassen, BT, Chang, SY and Lee, KH (2015) Motor and non-motor circuitry activation induced by subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson’s disease patients: intraoperative fMRI for DBS. Mayo Clinic Proceedings 90, 773–785.CrossRefGoogle Scholar
Krack, P, Batir, A, Van Blercom, N, Chabardes, S, Fraix, V, Ardouin, C, Koudsie, A, Limousin, PD, Benazzouz, A, LeBas, JF, Benabid, AL and Pollak, (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New England Journal of Medicine 349, 1925–1934.CrossRefGoogle ScholarPubMed
Kringelbach, ML, Jenkinson, N, Owen, SL and Aziz, TZ (2007) Translational principles of deep brain stimulation. Nature Reviews Neuroscience 8, 623–635.CrossRefGoogle ScholarPubMed
Mantione, M, Figee, M and Denys, D (2014) A case of musical preference for Johnny Cash following deep brain stimulation of the nucleus accumbens. Frontiers in Behavioral Neuroscience 8, 152.CrossRefGoogle Scholar
Mantione, M, Nieman, D, Figee, M, van den Munckhof, P, Schuurman, R and Denys, D (2015) Cognitive effects of deep brain stimulation in patients with obsessive–compulsive disorder. Journal of Psychiatry & Neuroscience 40, 378–386.CrossRefGoogle ScholarPubMed
Mayeux, R, Stern, Y, Rosen, J and Leventhal, J (1981) Depression, intellectual impairment, and Parkinson disease. Neurology 31, 645–650.CrossRefGoogle ScholarPubMed
Miocinovic, S, Somayajula, S, Chitnis, S and Vitek, JL (2013) History, applications, and mechanisms of deep brain stimulation. JAMA Neurology 70, 163–171.CrossRefGoogle ScholarPubMed
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG and Group, PRISMA (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine 6, e1000097.CrossRefGoogle ScholarPubMed
Molinuevo, JL, Valldeoriola, F, Tolosa, E, Rumia, J, Valls-Sole, J, Roldan, H and Ferrer, E (2000) Levodopa withdrawal after bilateral subthalamic nucleus stimulation in advanced Parkinson disease. Archives of Neurology 57, 983–988.CrossRefGoogle ScholarPubMed
Nakano, K (2000) Neural circuits and topographic organization of the basal ganglia and related regions. Brain and Development 22 Suppl 1, S5–S16.CrossRefGoogle ScholarPubMed
Okun, MS, Mann, G, Foote, KD, Shapira, NA, Bowers, D, Springer, U, Knight, W, Martin, P and Goodman, WK (2007) Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming. Journal of Neurology, Neurosurgery, and Psychiatry 78, 310–314.CrossRefGoogle ScholarPubMed
Rodriguez-Oroz, MC, Obeso, JA, Lang, AE, Houeto, JL, Pollak, P, Rehncrona, S, Kulisevsky, J, Albanese, A, Volkmann, J, Hariz, MI, Quinn, NP, Speelman, JD, Guridi, J, Zamarbide, I, Gironell, A, Molet, J, Pascual-Sedano, B, Pidoux, B, Bonnet, AM, Agid, Y, Xie, J, Benabid, AL, Lozano, AM, Saint-Cyr, J, Romito, L, Contarino, MF, Scerrati, M, Fraix, V and Van Blercom, N (2005) Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain 128, 2240–2249.CrossRefGoogle ScholarPubMed
Soulas, T, Gurruchaga, JM, Palfi, S, Cesaro, P, Nguyen, JP and Fénelon, G (2008) Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry 79, 952–954.CrossRefGoogle ScholarPubMed
Temel, Y, Kessels, A, Tan, S, Topdag, A, Boon, P and Visser-Vandewalle, V (2006) Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review. Parkinsonism & Related Disorders 12, 265–272.CrossRefGoogle ScholarPubMed
Thobois, S, Mertens, P, Guenot, M, Hermier, M, Mollion, H, Bouvard, M, Chazot, G, Broussolle, E and Sindou, M (2002) Subthalamic nucleus stimulation in Parkinson’s disease. Clinical evaluation of 18 patients. Journal of Neurology 249, 529–534.CrossRefGoogle ScholarPubMed
Vesper, J, Klostermann, F, Stockhammer, F, Funk, T and Brock, M (2002) Results of chronic subthalamic nucleus stimulation for Parkinson’s disease: a 1-year follow-up study. Surgical Neurology 57, 306–313.CrossRefGoogle ScholarPubMed
Videnovic, A and Metman, LV (2008) Deep brain stimulation for Parkinson’s disease: prevalence of adverse events and need for standardized reporting. Movement Disorders 23, 343–349.CrossRefGoogle ScholarPubMed
Wojtecki, L, Nickel, J, Timmermann, L, Maarouf, M, Südmeyer, M, Schneider, F, Seitz, RJ, Voges, J, Sturm, V and Schnitzler, A (2007) Pathological crying induced by deep brain stimulation. Movement Disorders 22, 1314–1316.CrossRefGoogle ScholarPubMed