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A transition density expansion for a multi-allele diffusion model

Published online by Cambridge University Press:  01 July 2016

R. C. Griffiths
R. C. Griffiths*
Affiliation:
Monash University
*
∗Postal address: Department of Mathematics, Monash University, Clayton, Victoria 3168, Australia.
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Abstract

An expansion in orthogonal polynomials is found for the transition density in a neutral multi-allele diffusion model where the mutation rates of allele types Ai → Aj are assumed to be uj(≥ O). The density is found when the mutation rate is positive for all allele types, and when some or all have zero mutation. The asymptotic conditional density is found for a mixture of positive and zero mutation rates.

The infinite alleles limit with equal mutation is studied. Eigenfunctions of the process are derived and the frequency spectrum found. An important result is that the first eigenfunction depends only on the homozygosity.

A density for the time to fixation with zero mutation is found for the K allele, and infinite alleles model.

Keywords

ALLELE FREQUENCYDIFFUSIONDIRICHLET DISTRIBUTIONORTHOGONAL POLYNOMIALSTRANSITION DENSITY
Type
Research Article
Information
Advances in Applied Probability , Volume 11 , Issue 2 , June 1979 , pp. 310 - 325
Copyright
Copyright © Applied Probability Trust 1979 

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