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Optimal sampling for pedigree analysis: tracing a single gene
Published online by Cambridge University Press: 01 July 2016
Abstract
In fitting genetic models on the basis of observations on an interrelated structure, sequential procedures can enhance efficiency. In this paper we consider the case of a rare gene segregating in a single large pedigree. The sampling rule is dictated by the effect of observations on the genotypic probability distribution of unobserved relatives; this effect is investigated.
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- Copyright © Applied Probability Trust 1982
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