This essay makes a case for an anthropological conceptualization of culture as “semiotic practices” and demonstrates how it adds value to political analyses. “Semiotic practices” refers to the processes of meaning-making in which agents' practices (e.g., their work habits, self-policing strategies, and leisure patterns) interact with their language and other symbolic systems. This version of culture can be employed on two levels. First, it refers to what symbols do—how symbols are inscribed in practices that operate to produce observable political effects. Second, “culture” is an abstract theoretical category, a lens that focuses on meaning, rather than on, say, prices or votes. By thinking of meaning construction in terms that emphasize intelligibility, as opposed to deep-seated psychological orientations, a practice-oriented approach avoids unacknowledged ambiguities that have bedeviled scholarly thinking and generated incommensurable understandings of what culture is. Through a brief exploration of two concerns central to political science—compliance and ethnic identity-formation—this paper ends by showing how culture as semiotic practices can be applied as a causal variable.