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Birth Defects in Twins: Study in a Spanish Population

Published online by Cambridge University Press:  01 August 2014

M.A. Ramos-Arroyo
M.A. Ramos-Arroyo*
Affiliation:
Department of Genetics, Hospital Virgen del Camino, Pamplona, Spain
*
Servicio de Genética, Hospital Virgen del Camino, C/Irunlarrea s/n, 31008 Pamplona, Spain.

Abstract

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The risk for specific defects among twins compared to singletons was studied using data collected by the Spanish Collaborative Study of Congenital Malformations (ECEMC). A total of 136 twins had a major and/or minor congenital defect. The overall rate of congenital defects in twins (2.37%) did not deviate significantly from the rate in singletons (2.21%). Like-sex (LS) and male-male (MM) twin pairs had a slightly higher rate of birth defects than unlike-sex (US) and female-female (FF) pairs, respectively. Defects of the central nervous system, cardiovascular system and genitourinary system were significantly more frequent in LS twins than in singletons, with relative risks of 2.8, 2.5 and 1.6, respectively. No significantly increased risk was found among US twins. Among defects of the central nervous system, the rates of anencephaly, encephalocele and hydrocephaly were significantly higher in total and LS twins; however, no significantly increased risk for spina bifida was observed when compared to singletons. MM twins were also 1.9 times more likely to have hypospadias, but the risk among males of male-female (FM) pairs was decreased.

Keywords

Birth defectTwinningNeural tube defectHypospadiasEpidemiology
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 3-4 , October 1991 , pp. 337 - 344
Copyright
Copyright © The International Society for Twin Studies 1991

References

REFERENCES

1. Barr, A, Stevenson, AC (1961): Stillbirths and infant mortality in twins. Human Genet 25:131–140.CrossRefGoogle ScholarPubMed
2. Benirschke, K (1865): Major pathological features of placenta, cord and membranes. Birth Defects Orig Art Ser 1:52–63.Google Scholar
3. Burn, J, Corney, G (1984): Congenital heart defects and twinning. Acta Genet Med Gemellol 33:61–69.Google Scholar
4. Carter, CO, Evans, K (1973): Spina bifida and anencephalus in greater London. J Med Genet 10:209–234.Google Scholar
5. Corney, G, MacGillivray, I (1983): Congenital anomalies in twins in Aberdeen and Northeast Scotland. Acta Genet Med Gemellol 32:31–35.Google Scholar
6. Czeizel, A, Toth, J, Erodi, E (1979): Aetiological studies of hypospadias in Hungary. Hum Hered 29:166–171.Google Scholar
7. Flynt, JW (1973): The extent of the birth defects problems. Pediatr Ann, 10, pp. 10–15.Google Scholar
8. Granroth, G. Haapakoski, J, Hakama, M (1978): Defects of the central nervous system in Finland. Birth order, outcome of previous pregnancies and family history. Teratology 17:213–222.Google Scholar
9. Hay, S, Wehrung, DA (1970): Congenital malformations in twins. Am J Hum Genet 22:662–678.Google Scholar
10. Hoyme, HE, Higginbottom, MC, Jones, JL (1981): Vascular etiology of dysruptive defects in monozygotic twins. Pediatrics 67:288–291.Google Scholar
11. James, WH (1976): Twinning and anencephaly. Ann Hum Biol 3:401–409.Google Scholar
12. Kallen, B (1986): Congenital malformations in twins: A population study. Acta Genet Med Gemellol 35:167–178.Google Scholar
13. Kallen, B, Bertollini, R, Castilla, E, Czeizel, A, Knudsen, LB, Martinez-Frias, ML, Mastroiacovo, P, Mutchinick, O (1986): A joint international study on the epidemiology of hypospadias. Acta Paediatr e Scand Suppl 324:1–51.Google Scholar
14. Layde, PM, Erickson, JD, Falek, A, McCarthy, BJ (1980): Congenital malformations in twins. Am J Hum Genet 32:69–78.Google Scholar
15. Leek, I (1984): The geographical distribution of neural tube defects and oral clefts. Br Med Bull 40:390–395.CrossRefGoogle Scholar
16. Leck, I, McKeown, T, Record, RG (1985): Cardiac malformations in a population observed for six years after birth. Br J Prev Soc Med 19:49–50.Google Scholar
17. Leung, TJ, Baird, PA, McGuilivray, B (1985): Hypospadias in British Columbia. Am J Med Genet 21:39–48.Google Scholar
18. Little, J, Bryan, E (1988): Cardiac anomalies. In MacGillivray, I, Thompson, B, Campbell, DM (eds): Twinning and Twins. London: Wiley, pp. 207–240.Google Scholar
19. Little, J, Nevin, NC (1989): Congenital anomalies in twins in Northern Ireland. I: Anomalies in general and specific anomalies other than neural tube defects and of the cardiovascular system, 1974-1979. Acta Genet Med Gemellol 38:1–6.Google Scholar
20. Livingston, JE, Poland, BJ (1980): A study of aborted twins. Teratology 21:139–148.Google Scholar
21. Monteleone, R, Castilla, EE, Paz, JE (1981): Hypospadias: An epidemiological study in Latin America, J Med Genet 10:5–19.Google Scholar
22. Myrianthopoulos, NC (1975): Congenital malformations in twins. Epidemiologic survey. Birth Defects Orig Art Ser 11:1–39.Google Scholar
23. Myrianthopoulos, NC (1987): Congenital malformations: The contribution of twin studies. Birth Defects Orig Art Ser 14:151–168.Google Scholar
24. Naeye, RL (1964): The fetal and neonatal development of twins. Pediatrics 33:546–553.Google Scholar
25. Nance, WE (1981): Malformations unique to twinning process. In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Twin Biology and Multiple Pregnancy. New York: Alan R Liss, pp. 123–133.Google Scholar
26. Ramos-Arroyo, MA, Ulbright, TM, Yu, PL, Christian, JC (1988): Twins study: Relationship between birth weight, zigosity and pathologic placental changes. Acta Genet Med Gemellol 37:229–238.Google Scholar
27. Stevenson, AC, Johnston, HA, Stewart, MIP, Golding, DR (1966): Congenital malformations. A report of a study of series of consecutive births in 24 centers. Bull who 34 (Suppl): 1–127.Google Scholar
28. Windham, GC, Bjerkedal, T (1984): Malformations in twins and their siblings, Norway 1967-79. Acta Genet Med Gemellol 33:87–95.Google Scholar
29. Windham, GC, Bjerkedal, T, Sever, LS (1982): The association of twinning and neural tube defects: studies in Los Angeles, California, and Norway. Acta Genet Med Gemellol 31:165–172.Google Scholar