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Cleidocranial dysostosis in a family with twins*

Published online by Cambridge University Press:  01 August 2014

J. Spital ,
G. Schellong ,
W. Scholz ,
H. Mai  and
O. Frh. v. Verschuer
J. Spital
Affiliation:
Universitäts-Kinderklinik Münster (Westf.) Humangenetisches Institut der Universität Münster (Westf.)
G. Schellong
Affiliation:
Universitäts-Kinderklinik Münster (Westf.) Humangenetisches Institut der Universität Münster (Westf.)
W. Scholz
Affiliation:
Universitäts-Kinderklinik Münster (Westf.) Humangenetisches Institut der Universität Münster (Westf.)

Summary

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A family is reported in which 5 individuals out of 2 generations were found to suffer from dysostosis cleidocranialis. In that kindred twins occurred twice, one twin pair being DZ and suffering from the disease, the other pair MZ and healthy. The number of affected family members is in agreement with the autosomal dominance of the trait as indicated by numerous earlier observations. The characteristics found were: reduced growth, macrocephalus with late fontanel occlusion, protrusive frontal bone, hypertelorism, dysplasia of the clavicles and the pelvis, retarded development of hand skeleton. There was a certain variability in the expression of the traits in both DZ twin sisters, particularly concerning the malformation of clavicles and pelvis. Their children showed rather uniform alterations concerning head and hand skeleton, clavicles and pelvis.

Blood group tests performed did not reveal linked inheritance of the pathological trait and any of the used serological markers.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 16 , Issue 2 , April 1967 , pp. 159 - 171
Copyright
Copyright © The International Society for Twin Studies 1967

Footnotes

*

Herrn Prof. Dr. O. Frh. v. Verschuer zum 70. Geburtstag in Verehrung gewidmet.

References

Literaturverzeichnis

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