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Delayed Ovulation and Monozygotic Twinning

Published online by Cambridge University Press:  01 August 2014

Ondine Bomsel-Helmreich  and
Emile Papiernik-Berkhauer
Ondine Bomsel-Helmreich*
Affiliation:
Research Laboratory, Department of Obstetrics and Gynecology, Antoine Beclere Hospital, Clamart, France
Emile Papiernik-Berkhauer
Affiliation:
Research Laboratory, Department of Obstetrics and Gynecology, Antoine Beclere Hospital, Clamart, France
*
Laboratoire de Recherche du Service de Gynécologie-Obstétrique, Hôpital Antoine Béclère, 157 rue de la Porte Trivaux, 92140 Clamart, France

Abstract

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Aiming to show that delayed ovulation may induce MZ twinning, follicular maturation was induced in the rabbit by a small quantity of Pregnant Mare Serum Gonadotropin (16 UI four times): coitus, which induces ovulation in the rabbit, was delayed 60 hours after the last injection. From the 387 blastocysts obtained after this treatment, 6 (7.5%) were pairs of MZ twins, twinning being otherwise exceptional in the rabbit. Other anomalies were shown by the embryos, apparently related to a deficient quality of the eggs: high embryonic mortality (62% vs. 27% in controls) and chromosomal anomalies (20%) such as trisomies, triploidies, and chimaeras. The relation between MZ twinning, chromosomal anomalies, and embryonic mortality induced by delayed ovulation, could be connected and related to the poor perinatal conditions frequently observed in human MZ twins.

Type
2. The Twinning Phenomenon
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 73 - 76
Copyright
Copyright © The International Society for Twin Studies 1976

References

REFERENCES

Aurias, A., Lejeune, J. 1974. Monozygotic hetero-caryotic twinning. Proc. 1st Int. Congr. Twin Studies, Rome. Acta Genet. Med. Gemellol. (Roma), 25: 50–52.Google Scholar
Bomsel-Helmreich, O. 1975. Experimental hetero-ploidy in mammals. In Gropp, A. (ed.): Current Topics in Pathology. Berlin: Springer.Google Scholar
Butcher, R.L., Blue, J.D., Fugo, N.W. 1969. Over-ripeness and the mammalian ova. III. Fetal development at midgestation and at term. Fertil. Steril., 20: 222–229.Google Scholar
Nance, W.E., Uchida, I. 1964. Turner's syndrome, twinning and an unusual variant of glucoses-phosphate dehydrogenase. Am. J. Hum. Genet.. 16, 380–390.Google Scholar
Riekhof, P.L., Horton, W.A., Harris, D.J., Schimke, J.N. 1972. Monozygotic twins with the Turner syndrome. Am. J. Obstet. Gynecol., 112: 59–61.CrossRefGoogle ScholarPubMed
Witschi, E. 1952. Overripeness of the egg as a cause of twinning and teratogenesis. Cancer Res., 12: 763–786.Google ScholarPubMed