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Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

Published online by Cambridge University Press:  01 August 2014

C.-J. Chen ,
M.-W. Yu ,
C.-J. Wang ,
S.-L. Tong ,
M. Tien ,
T.-Y. Lee ,
H.-C. Lue ,
F.-Y. Huang ,
C.-C. Lan  and
K.-H. Yang
...Show all authors
C.-J. Chen*
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
M.-W. Yu
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
C.-J. Wang
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
S.-L. Tong
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
M. Tien
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
T.-Y. Lee
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
H.-C. Lue
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
F.-Y. Huang
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
C.-C. Lan
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
K.-H. Yang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-C. Wang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-Y. Shin
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
C.-Y. Liu
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
J.-S. Chen
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
*
Institute of Public Health, National Taiwan University College of Medicine, 1, Jen-Ai Road Section 1, Taipei 10018, Taiwan, Republic of China

Abstract

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In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

Keywords

HeritabilitySerum lipidsNeonatesTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 1 , January 1990 , pp. 123 - 131
Copyright
Copyright © The International Society for Twin Studies 1990

References

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