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Selection Bias in Disease-Related Twin Studies — Data on 11,154 Adult Finnish Twin Pairs from a Nationwide Panel

Published online by Cambridge University Press:  01 August 2014

K. Romanov ,
M. Koskenvuo ,
J. Kaprio ,
S. Sarna  and
K. Heikkilä
K. Romanov*
Affiliation:
Department of Public Health, University of Helsinki, Finland
M. Koskenvuo
Affiliation:
Department of Public Health, University of Turku, Finland
J. Kaprio
Affiliation:
Department of Public Health, University of Helsinki, Finland
S. Sarna
Affiliation:
Department of Public Health, University of Helsinki, Finland
K. Heikkilä
Affiliation:
Department of Public Health, University of Helsinki, Finland
*
Department of Public Health, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland

Abstract

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The effect of migration on pairwise concordance for disease was assessed in 11,154 twin pairs of the Finnish Twin Cohort Study by comparing the pairs living in the same province to the pairs which members were living in different provinces of Finland. The cumulative incidence of psychosis and hypertension for the years 1972-1985 were analyzed. The cumulative concordance of psychosis for those MZ twin pairs living in the same province were higher than for those MZ pairs living further apart. Similar findings were found among DZ pairs for psychosis. The cumulative concordance of hypertension was only slightly higher among those MZ and DZ pairs living in the same province compared with pairs living in different provinces. These results indicate an overestimation of concordance of psychosis caused by selective migration. This bias in twin studies is likely to influence heritability estimates in a sample of limited geographical area.

Keywords

TwinsConcordanceSelection biasPsychosisHypertension
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 4 , October 1990 , pp. 441 - 446
Copyright
Copyright © The International Society for Twin Studies 1990

References

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