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“Silent” Patent Ductus Arteriosus and Bronchopulmonary Dysplasia in Low-Birthweight Twins

Published online by Cambridge University Press:  01 August 2014

V. Zanardo ,
D. Trevisanuto ,
C. Dani ,
O. Milanesi ,
A. Guglielmi  and
F. Cantarutti
V. Zanardo*
Affiliation:
Department of Pediatrics
D. Trevisanuto
Affiliation:
Department of Pediatrics
C. Dani
Affiliation:
Department of Pediatrics
O. Milanesi
Affiliation:
Department of Pediatrics
A. Guglielmi
Affiliation:
Department of Pediatrics
F. Cantarutti
Affiliation:
Department of Pediatrics
*
Dipartimento di Pediatria, Università di Padova, Via Giustiniani, 8, 35128 Padova, Italia

Abstract

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During a screening protocol of early echocardiographic diagnosis (ATL MK 600) and treatment of “silent” PDA in RDS preterms with BW ≤ 1.750 kg, clinical data on premature twins were collected, including diagnosis of both PDA and BPD, to investigate whether twin birth influences PDA incidence and BPD development. Out of the 290 RDS preterms evaluated, 96 (33%) showed evidence of PDA, and a total of 79 (27%) developed BPD, 47 (16%) with associated PDA and 32 (11%) without PDA. Out of 238 singletons, 74 (31%) presented “silent” PDA and a total of 75 (31%) developed BPD, 44 (18%) with associated PDA, and 31 (13%) without PDA. In 52 other twins (18% of the total number of babies studied), 22 (42% of this subgroup) presented evidence of “silent” PDA, and 4 (8% of the subgroup), developed BPD, 3 with associated PDA (6% of the subgroup), and 1 without PDA (2% of the subgroup). From these data, it is inferred that that low-birthweight twins are at high risk for PDA hemodynamic complications during RDS, and may benefit from early induced ductal closure. Instead, in RDS twins, BPD was statistically less frequent (at the 99% C.L.) probably because twinning enhances fetal lung maturity, influencing enzymatic and nonenzymatic protective systems of lung defence.

Keywords

Bronchopulmonary dysplasia“Silent” PDAPremature twinsRespiratory distress syndrome
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 42 , Issue 3-4 , October 1993 , pp. 253 - 256
Copyright
Copyright © The International Society for Twin Studies 1993

Footnotes

* National Institute for Nuclear Physics, Padua University, Italy

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