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Sulla Genetica del Diabete Analisi di nove casi famigliari

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
D. Casa  and
G. Brenci
L. Gedda*
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
D. Casa
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
G. Brenci
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
*
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Piazza Galeno 5, 00161 Roma, Italy

Summary

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Nine family cases of diabetes are genetically interpreted on account of a polygenic model of inheritance, with each allele being characterized by a different probability of chronological stability of the normal information. This model provides a satisfactory interpretation of the clinical and subclinical variability of diabetes — which the diallelic model is unable to do — and has on the polygenic model the advantage of a higher fitness to a case of discontinuous variability, such as diabetes. Both pedigrees characterized by apparent recessive inheritance and those characterized by apparent dominant one may equally be interpreted on account of the polyallelic model.

The origin of polyallelism is attributed to the hereditary variability of the gene's temporal unit (chronon). As a result, the phenomenon of “anticipation” may also be interpreted, and the one-origin clinical and sub-clinical variability of diabetes be demonstrated.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 3 , July 1970 , pp. 385 - 398
Copyright
Copyright © The International Society for Twin Studies 1970

References

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